| HGNC approved symbol | SKP1 |
| HGNC ID | HGNC:10899 |
| HGNC approved name | S-phase kinase-associated protein 1 |
| Entrez gene ID | GeneID:6500 (SSTAR profile) |
| UniProt AC (human) | P63208 |
| UniProt ID (human) | SKP1_HUMAN |
| Pfam domains | Skp1_POZ PF03931 (3-68) Skp1 PF01466 (113-160) |
| MGI symbol | Akp1a |
| MGI ID | MGI:103575 |
| UniProt AC (mouse) | Q9WTX5 |
| UniProt ID (mouse) | SKP1_MOUSE |
| HGNC gene family tag | # |
| HGNC gene family description | # |
| Function | Histone modification write cofactor |
| Modification | Histone ubiquitination |
| PMID for information on function | PMID:16943429 |
| Protein complex | BCOR |
| Target molecule | histone |
| Target entity | # |
| Product | # |
| PMID for information on target | PMID:16943429 |
| Comment | The proteins in the BCOR complex include the PcG and PcG-associated proteins NSPC1, RING1, RNF2, and RYBP as well as components of an SCF ubiquitin ligase, SKP1, and FBXL10. BCOR recruits a unique combination of enzymatic activities to chromatin targets: a PcG E3 ubiquitin ligase for histone H2A, a demethylase for histone H3 K36, and an SCF E3 ubiquitin ligase. |
| Status of entry | # |
| Expression range: | 107.46 to 1444.7 |
| Mean expression: | 513.14 ± 180.62 |
| Median expression: | 497.37 |