HGNC approved symbol | TDG |
HGNC ID | HGNC:11700 |
HGNC approved name | thymine-DNA glycosylase |
Entrez gene ID | GeneID:6996 (SSTAR profile) |
UniProt AC (human) | Q13569 |
UniProt ID (human) | TDG_HUMAN |
Pfam domains | UDG PF03167 (129-288) |
MGI symbol | Tdg |
MGI ID | MGI:108247 |
UniProt AC (mouse) | P56581 |
UniProt ID (mouse) | TDG_MOUSE |
HGNC gene family tag | # |
HGNC gene family description | # |
Function | DNA modification |
Modification | DNA hydroxymethylation |
PMID for information on function | PMID:22962365 |
Protein complex | # |
Target molecule | DNA |
Target entity | G:U, G:T, G:hmU |
Product | C, 5mC, 5hmC |
PMID for information on target | PMID:22962365 |
Comment | The mammalian thymine DNA glycosylase (TDG) is implicated in active DNA demethylation via the base excision repair pathway. |
Status of entry | # |