| HGNC approved symbol | TET2 |
| HGNC ID | HGNC:25941 |
| HGNC approved name | tet methylcytosine dioxygenase 2 |
| Entrez gene ID | GeneID:54790
(SSTAR profile) |
| UniProt AC (human) | Q6N021 |
| UniProt ID (human) | TET2_HUMAN |
| Pfam domains | Tet_JBP PF12851 (1290-1904) |
| MGI symbol | Tet2 |
| MGI ID | MGI:2443298 |
| UniProt AC (mouse) | Q4JK59 |
| UniProt ID (mouse) | TET2_MOUSE |
| HGNC gene family tag | # |
| HGNC gene family description | # |
| Function | DNA modification |
| Modification | DNA hydroxymethylation |
| PMID for information on function | PMID:23222540 |
| Protein complex | # |
| Target molecule | DNA |
| Target entity | mC |
| Product | hmC |
| PMID for information on target | PMID:23222540 |
| Comment | Ten eleven translocation (TET) enzymes, including TET1, TET2 and TET3, convert 5-methylcytosine to 5-hydroxymethylcytosine and regulate gene transcription. Downregulation of TET2 reduces the amount of histone 2B Ser 112 GlcNAc marks in vivo, which are associated with gene transcription regulation. |
| Status of entry | # |