HGNC approved symbol | TLK1 |
HGNC ID | HGNC:11841 |
HGNC approved name | tousled-like kinase 1 |
Entrez gene ID | GeneID:9874 (SSTAR profile) |
UniProt AC (human) | Q9UKI8 |
UniProt ID (human) | TLK1_HUMAN |
Pfam domains | Pkinase PF00069 (458-734) |
MGI symbol | Tlk1 |
MGI ID | MGI:2441683 |
UniProt AC (mouse) | Q8C0V0 |
UniProt ID (mouse) | TLK1_MOUSE |
HGNC gene family tag | # |
HGNC gene family description | # |
Function | Histone modification write |
Modification | Histone phosphorylation |
PMID for information on function | PMID:11314006 |
Protein complex | # |
Target molecule | histone |
Target entity | H3S10 |
Product | H3S10ph |
PMID for information on target | PMID:11314006 |
Comment | Purified TLK1B phosphorylates histone H3 at S(10) with high specificity both in a mix of core histones and in isolated chromatin, suggesting that histone H3 is a physiological substrate for TLK1B. |
Status of entry | # |