HGNC approved symbol | TLK2 |
HGNC ID | HGNC:11842 |
HGNC approved name | tousled-like kinase 2 |
Entrez gene ID | GeneID:11011 (SSTAR profile) |
UniProt AC (human) | Q86UE8 |
UniProt ID (human) | TLK2_HUMAN |
Pfam domains | Pkinase PF00069 (464-741) |
MGI symbol | Tlk2 |
MGI ID | MGI:1346023 |
UniProt AC (mouse) | O55047 |
UniProt ID (mouse) | TLK2_MOUSE |
HGNC gene family tag | # |
HGNC gene family description | # |
Function | Histone modification write |
Modification | Histone phosphorylation |
PMID for information on function | PMID:12660173 |
Protein complex | # |
Target molecule | chromatin |
Target entity | # |
Product | # |
PMID for information on target | PMID:12660173 |
Comment | There is a functional co-operation between ATM and Chk1 in propagation of a checkpoint response during S phase, suggesting that, through transient inhibition of Tlk kinases, the ATM-Chk1-Tlk pathway may regulate processes involved in chromatin assembly. |
Status of entry | # |