HGNC approved symbol | TP53BP1 |
HGNC ID | HGNC:11999 |
HGNC approved name | tumor protein p53 binding protein 1 |
Entrez gene ID | GeneID:7158 (SSTAR profile) |
UniProt AC (human) | Q12888 |
UniProt ID (human) | TP53B_HUMAN |
Pfam domains | 53-BP1_Tudor PF09038 (1481-1604) BRCT_3 PF18428 (1866-1968) |
MGI symbol | Trp53bp1 |
MGI ID | MGI:1351320 |
UniProt AC (mouse) | P70399 |
UniProt ID (mouse) | TP53B_MOUSE |
HGNC gene family tag | # |
HGNC gene family description | # |
Function | Histone modification read |
Modification | # |
PMID for information on function | PMID:15525939 |
Protein complex | # |
Target molecule | histone |
Target entity | H4K79me2, H4K20me2 |
Product | # |
PMID for information on target | PMID:15525939 |
Comment | In vitro, the 53BP1 =TP53BP1 tandem tudor domain binds histone H3 methylated on Lys 79 using residues that form the walls of the pocket; these residues are also required for recruitment of 53BP1 to DSBs. |
Status of entry | # |
Expression range: | 0.0 to 90.34 |
Mean expression: | 17.75 ± 11.16 |
Median expression: | 15.2 |