HGNC approved symbol | UBE2N |
HGNC ID | HGNC:12492 |
HGNC approved name | ubiquitin-conjugating enzyme E2N |
Entrez gene ID | GeneID:7334 (SSTAR profile) |
UniProt AC (human) | P61088 |
UniProt ID (human) | UBE2N_HUMAN |
Pfam domains | UQ_con PF00179 (7-143) |
MGI symbol | Ube2n |
MGI ID | MGI:1934835 |
UniProt AC (mouse) | P61089 |
UniProt ID (mouse) | UBE2N_MOUSE |
HGNC gene family tag | UBE2 |
HGNC gene family description | Ubiquitin-conjugating enzymes E2 |
Function | Histone modification write |
Modification | Histone ubiquitination |
PMID for information on function | PMID:17709392 |
Protein complex | # |
Target molecule | histone |
Target entity | H2AX |
Product | H2AXub |
PMID for information on target | PMID:17709392 |
Comment | TIP60 regulates the ubiquitination of H2AX via the ubiquitin-conjugating enzyme UBC13 (=UBE2N), which is induced by DNA damage. |
Status of entry | # |