HGNC approved symbol | UBR2 |
HGNC ID | HGNC:21289 |
HGNC approved name | ubiquitin protein ligase E3 component n-recognin 2 |
Entrez gene ID | GeneID:23304 (SSTAR profile) |
UniProt AC (human) | Q8IWV8 |
UniProt ID (human) | UBR2_HUMAN |
Pfam domains | zf-UBR PF02207 (99-167) ClpS PF02617 (222-301) domain PF22960 (778-872) PRT6_C PF18995 (1309-1729) |
MGI symbol | Ubr2 |
MGI ID | MGI:1861099 |
UniProt AC (mouse) | Q6WKZ8 |
UniProt ID (mouse) | UBR2_MOUSE |
HGNC gene family tag | UBR |
HGNC gene family description | Ubiquitin protein ligase E3 component n-recognins |
Function | Histone modification write |
Modification | Histone ubiquitination |
PMID for information on function | # |
Protein complex | # |
Target molecule | histone |
Target entity | H2A |
Product | # |
PMID for information on target | # |
Comment | Plays a critical role in chromatin inactivation and chromosome-wide transcriptional silencing during meiosis via ubiquitination of histone H2A. (Annotated by similarity.) |
Status of entry | # |
Expression range: | 2.8 to 329.56 |
Mean expression: | 29.96 ± 28.62 |
Median expression: | 22.77 |