| HGNC approved symbol | UCHL5 |
| HGNC ID | HGNC:19678 |
| HGNC approved name | ubiquitin carboxyl-terminal hydrolase L5 |
| Entrez gene ID | GeneID:51377 (SSTAR profile) |
| UniProt AC (human) | Q9Y5K5 |
| UniProt ID (human) | UCHL5_HUMAN |
| Pfam domains | Peptidase_C12 PF01088 (8-209) UCH_C PF18031 (265-309) |
| MGI symbol | Uchl5 |
| MGI ID | MGI:1914848 |
| UniProt AC (mouse) | Q9WUP7 |
| UniProt ID (mouse) | UCHL5_MOUSE |
| HGNC gene family tag | INO80 |
| HGNC gene family description | INO80 complex subunits |
| Function | Histone modification erase cofactor |
| Modification | Histone ubiquitination |
| PMID for information on function | PMID:18922472 |
| Protein complex | Ino80 |
| Target molecule | histone |
| Target entity | # |
| Product | # |
| PMID for information on target | PMID:18922472 |
| Comment | Deubiquitination by Uch37 is activated by proteasomal binding, which enables Uch37 to process polyubiquitin chains. In the nucleus Uch37 is also associated with the human Ino80 chromatin-remodeling complex (hINO80). In hINO80, Uch37 is held in an inactive state; however, it can be activated by transient interaction of the Ino80 complex with the proteasome. |
| Status of entry | # |
| Expression range: | 2.99 to 131.95 |
| Mean expression: | 33.12 ± 21.07 |
| Median expression: | 28.48 |