HGNC approved symbol | UHRF1 |
HGNC ID | HGNC:12556 |
HGNC approved name | ubiquitin-like with PHD and ring finger domains 1 |
Entrez gene ID | GeneID:29128 (SSTAR profile) |
UniProt AC (human) | Q96T88 |
UniProt ID (human) | UHRF1_HUMAN |
Pfam domains | ubiquitin PF00240 (2-75) TTD PF12148 (133-285) PHD PF00628 (318-363) SAD_SRA PF02182 (417-585) |
MGI symbol | Uhrf1 |
MGI ID | MGI:1338889 |
UniProt AC (mouse) | Q8VDF2 |
UniProt ID (mouse) | UHRF1_MOUSE |
HGNC gene family tag | RNF |
HGNC gene family description | RING-type (C3HC4) zinc fingers |
Function | Histone modification read, Histone modification write cofactor |
Modification | Histone ubiquitination |
PMID for information on function | PMID:17967883 |
Protein complex | # |
Target molecule | histone, DNA |
Target entity | H3K9me3, H3R2, H3, mCG |
Product | H3ub |
PMID for information on target | PMID:17967883 |
Comment | ICBP90 =UHRF1and its murine homologue Np95 are enriched in pericentric heterochromatin of interphase nuclei, and this localization is dependent on H3K9 methylation. |
Status of entry | # |
Expression range: | 0.0 to 482.88 |
Mean expression: | 23.6 ± 38.15 |
Median expression: | 10.98 |