HGNC approved symbol | UHRF2 |
HGNC ID | HGNC:12557 |
HGNC approved name | ubiquitin-like with PHD and ring finger domains 2, E3 ubiquitin protein ligase |
Entrez gene ID | GeneID:115426 (SSTAR profile) |
UniProt AC (human) | Q96PU4 |
UniProt ID (human) | UHRF2_HUMAN |
Pfam domains | ubiquitin PF00240 (2-74) TTD PF12148 (125-311) PHD PF00628 (347-392) SAD_SRA PF02182 (445-614) |
MGI symbol | Uhrf2 |
MGI ID | MGI:1923718 |
UniProt AC (mouse) | Q7TMI3 |
UniProt ID (mouse) | UHRF2_MOUSE |
HGNC gene family tag | RNF, PHF |
HGNC gene family description | RING-type (C3HC4) zinc fingers, Zinc fingers, PHD-type |
Function | Histone modification read |
Modification | # |
PMID for information on function | PMID:15361834 |
Protein complex | # |
Target molecule | histone, DNA |
Target entity | H3K9me3, mCG |
Product | # |
PMID for information on target | PMID:15361834 |
Comment | The SRA domain of the murine homologue of ICBP90=UHRF2, Np95, has histone H3-binding activity (Citterio et al., 2004). Methylated DNA twisted around histone H3 might be the primary target for Np95 and ICBP90 in vivo. |
Status of entry | # |
Expression range: | 4.17 to 231.22 |
Mean expression: | 30.97 ± 19.21 |
Median expression: | 26.65 |