| HGNC approved symbol | USP22 |
| HGNC ID | HGNC:12621 |
| HGNC approved name | ubiquitin specific peptidase 22 |
| Entrez gene ID | GeneID:23326 (SSTAR profile) |
| UniProt AC (human) | Q9UPT9 |
| UniProt ID (human) | UBP22_HUMAN |
| Pfam domains | zf-UBP PF02148 (63-123) UCH PF00443 (176-517) |
| MGI symbol | Usp22 |
| MGI ID | MGI:2144157 |
| UniProt AC (mouse) | Q5DU02 |
| UniProt ID (mouse) | UBP22_MOUSE |
| HGNC gene family tag | USP |
| HGNC gene family description | Ubiquitin-specific peptidases |
| Function | Histone modification write cofactor |
| Modification | Histone ubiquitination |
| PMID for information on function | PMID:18469533 |
| Protein complex | SAGA |
| Target molecule | histone |
| Target entity | H2Aub, H2Bub |
| Product | H2A, H2B |
| PMID for information on target | PMID:18469533 |
| Comment | USP22 deubiquitylates histone H2A in addition to H2B. This supports a model in which the H2A ubiquitin hydrolase USP22 is coordinately expressed with Polycomb H2A ubiquitin ligases in order that the transcription of certain critical transforming genes be maintained in the face of the global repression mediated by Polycomb. |
| Status of entry | # |
| Expression range: | 0.0 to 364.0 |
| Mean expression: | 121.28 ± 51.17 |
| Median expression: | 115.15 |