| HGNC approved symbol | HGNC ID | HGNC approved name | Entrez gene ID | UniProt AC (human) | UniProt ID (human) | Pfam domains | MGI symbol | MGI ID | UniProt AC (mouse) | UniProt ID (mouse) | HGNC gene family tag | HGNC gene family description | Function | Modification | PMID for information on function | Protein complex | Target molecule | Target entity | Product | PMID for information on target | Comment | Status of entry |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
CTCF
(details) |
13723 | CCCTC-binding factor (zinc finger protein) | 10664 | P49711 | CTCF_HUMAN | zf-C2H2 PF00096 266-288 294-316 322-345 351-373 379-401 437-460 555-575 | Ctcf | 109447 | Q61164 | CTCF_MOUSE | ZNF | Zinc fingers, C2H2-type | Chromatin remodeling, TF | TF activator | 16949368 | # | DNA | DNA motif | # | 16949368 | A CTCF-CHD8 complex is involved in both enhancer blocking and epigenetic remodeling at chromatin boundary in vivo. | # |
|
CTCFL
(details) |
16234 | CCCTC-binding factor (zinc finger protein)-like | 140690 | Q8NI51 | CTCFL_HUMAN | zf-C2H2 PF00096 313-336 342-364 398-421 428-451 546-566 | Ctcfl | 3652571 | A2APF3 | CTCFL_MOUSE | ZNF | Zinc fingers, C2H2-type | Chromatin remodeling | # | 18765639 | # | DNA | # | # | 18765639 | BORIS=CTCFL acts as a scaffold upon which BAT3 and SET1A assemble and through which BAT3 and SET1A exert their effects upon chromatin structure and gene expression. In contrast to CTCF, BORIS appears to be a methylation-independent DNA-binding protein (28b) that activates, rather than inhibits, gene expression. | # |