HGNC approved symbol HGNC ID HGNC approved name Entrez gene ID UniProt AC (human)
UniProt ID (human)
Pfam domains MGI symbol MGI ID UniProt AC (mouse)
UniProt ID (mouse)
HGNC gene family tag HGNC gene family description Function Modification PMID for information on function Protein complex Target molecule Target entity Product PMID for information on target Comment Status of entry
JADE1
(details) 		30027 jade family PHD finger 1 79960 Q6IE81 JADE1_HUMAN EPL1 PF10513 17-181, PHD_2 PF13831 218-251, zf-HC5HC2H_2 PF13832 256-369 Jade1 1925835 Q6ZPI0 JADE1_MOUSE PHF Zinc fingers, PHD-type Histone modification write Histone acetylation 16387653 HBO1 histone H3, H4 H3ac, H4ac 16387653 HBO1-JADE(1,2,3=PHF15,PHF16,PHF17)-ING-hEAF6 tetramer complexes are likely responsible for the majority of histone H4 acetylation higher eukaryotes. #
JADE2
(details) 		22984 jade family PHD finger 2 23338 Q9NQC1 JADE2_HUMAN EPL1 PF10513 16-177, PHD_2 PF13831 214-247, zf-HC5HC2H_2 PF13832 253-364 Jade2 1924151 Q6ZQF7 JADE2_MOUSE PHF Zinc fingers, PHD-type Histone modification write Histone acetylation 16387653 HBO1 histone H3, H4 H3ac, H4ac 16387653 HBO1-JADE(1,2,3=PHF15,PHF16,PHF17)-ING-hEAF6 tetramer complexes are likely responsible for the majority of histone H4 acetylation higher eukaryotes. #
PHF1
(details) 		8919 PHD finger protein 1 5252 O43189 PHF1_HUMAN Tudor_2 PF18104 34-69, PHD PF00628 90-139, Mtf2_C PF14061 534-564 Phf1 98647 Q9Z1B8 PHF1_MOUSE TDRD, PHF Tudor domain containing, Zinc fingers, PHD-type Polycomb group (PcG) protein # 18086877 PRC2 # # # 18086877 The EED-EZH2 complex, containing the core subunits EZH2, EED, SUZ12, and RbAp48, functions as a histone H3K27-specific methyltransferase. The related EED-EZH2 protein complex is distinguished from the previous complex by the presence of another PcG protein, hPHF1. #
PHF10
(details) 		18250 PHD finger protein 10 55274 Q8WUB8 PHF10_HUMAN PHD PF00628 380-433 436-478 Phf10 1919307 Q9D8M7 PHF10_MOUSE PHF Zinc fingers, PHD-type Chromatin remodeling # 20068294 npBAF, SWI/SNF BRM-BRG1 chromatin # # 20068294 PHF10 belongs to a family of plant homeodomain (PHD) containing proteins which play a role in transcription regulation via chromatin remodeling. #
PHF12
(details) 		20816 PHD finger protein 12 57649 Q96QT6 PHF12_HUMAN PHD PF00628 59-102 273-318, PHF12_MRG_bd PF16737 201-236 Phf12 1924057 Q5SPL2 PHF12_MOUSE PHF Zinc fingers, PHD-type Histone modification erase cofactor Histone acetylation 11390640 # histone # # 11390640 Pf1 =PHF12 is a novel PHD zinc finger protein that links the TLE corepressor to the mSin3A-histone deacetylase complex. #
PHF13
(details) 		22983 PHD finger protein 13 148479 Q86YI8 PHF13_HUMAN PHD_5 PF20826 226-279 Phf13 2446217 Q8K2W6 PHF13_MOUSE PHF Zinc fingers, PHD-type Histone modification read # 19638409 # histone H3K4me3 # 19638409 Interacts with histone H3 that is trimethylated at 'Lys-4' (H3K4me3). #
PHF14
(details) 		22203 PHD finger protein 14 9678 O94880 PHF14_HUMAN PHD_2 PF13831 334-359, zf-HC5HC2H_2 PF13832 384-498, PHD PF00628 728-776 871-918 Phf14 1923539 Q9D4H9 PHF14_MOUSE PHF Zinc fingers, PHD-type Histone modification read # 23688586 # histone H2A, H2B, H3 H2Aac, H2Bac, H3ac 23688586 PHF14α is bound to histones. Histone H3, H2A, and H2B can be co-immunoprecipitated with GFP-PHF14α, but not with GFP alone, from total cell lysate. Histones H3, H2A, and H2B can be pulled down together with non-tagged exogenous PHF14α using an anti-PHF14 antibody. #
PHF19
(details) 		24566 PHD finger protein 19 26147 Q5T6S3 PHF19_HUMAN Tudor_2 PF18104 43-78, PHD PF00628 99-148, Mtf2_C PF14061 531-578 Phf19 1921266 Q9CXG9 PHF19_MOUSE TDRD, PHF Tudor domain containing, Zinc fingers, PHD-type Chromatin remodeling, Histone modification write cofactor Histone acetylation 15563832 PRC2 histone # # 15563832 Based on motifs identified within the hPCL3 =PHF19 open reading frames, hPCL3 proteins are likely to be nuclear proteins that regulate transcription and/or chromatin structure. #