Lncrna info
HGNC approved symbolLINC00511
Alternative namesonco-lncRNA-12
HGNC approved namelong intergenic non-protein coding RNA 511
Entrez gene IDGeneID:400619
(SSTAR profile)
HGNC gene family tagLINC
HGNC gene family descriptionLong intergenic non-protein coding RNAs
FunctionHistone modifier recruitment, miRNA sponging
PMID for reference on functionPMID:32368318, PMID:32196597, PMID:32092829, 31646568, PMID:31417312, PMID:31395854
Target molecule typeRNA, DNA, Protein
Specific targetKDM1A, EZH2, miR-124-3p, miR 150-5p, miR-153-5p, miR-185-3p
PMID for reference on targets and productsPMID:32368318, PMID:32196597, PMID:32092829, 31646568, PMID:31417312, PMID:31395854
CommentActs as molecular sponge of miR-124-3p, miR 150-5p, miR-153-5p, miR-185-3p. In the present study, Binds KDM1A and EZH2. It inhibited expressions of p21, p57 LATS2 and KLF2 by binding to their promoter region. Interaction with EZH2 leads to recruitment PRC2 to mediate histone DNA Methylation, contributing to the G1/S transition to sustain cell proliferation. Maintaines the stability of Snail by impeding its ubiquitination and degradation by the BTRC E3 ubiquitin protein.
Status of entryNew

Expression statistics
Expression range: N/A
Mean expression: N/A
Median expression: N/A
Sample class Sample Expression (RLE-normalized CAGE tags per million)
Quantile over all genes