| HGNC approved symbol | LINC00511 |
| HGNC ID | HGNC:43564 |
| Alternative names | onco-lncRNA-12 |
| HGNC approved name | long intergenic non-protein coding RNA 511 |
| Entrez gene ID | GeneID:400619
(SSTAR profile) |
| HGNC gene family tag | LINC |
| HGNC gene family description | Long intergenic non-protein coding RNAs |
| Function | Histone modifier recruitment, miRNA sponging |
| PMID for reference on function | PMID:32368318, PMID:32196597, PMID:32092829, 31646568, PMID:31417312, PMID:31395854 |
| Target molecule type | RNA, DNA, Protein |
| Specific target | KDM1A, EZH2, miR-124-3p, miR 150-5p, miR-153-5p, miR-185-3p |
| Target UniProt ID | KDM1A_HUMAN, EZH2_HUMAN |
| PMID for reference on targets and products | PMID:32368318, PMID:32196597, PMID:32092829, 31646568, PMID:31417312, PMID:31395854 |
| Comment | Acts as molecular sponge of miR-124-3p, miR 150-5p, miR-153-5p, miR-185-3p. In the present study, Binds KDM1A and EZH2. It inhibited expressions of p21, p57 LATS2 and KLF2 by binding to their promoter region. Interaction with EZH2 leads to recruitment PRC2 to mediate histone DNA Methylation, contributing to the G1/S transition to sustain cell proliferation. Maintaines the stability of Snail by impeding its ubiquitination and degradation by the BTRC E3 ubiquitin protein. |
| Status of entry | New |