| HGNC approved symbol | NEAT1 |
| HGNC ID | HGNC:30815 |
| Alternative names | NCRNA00084, TncRNA, MENepsilon/beta, LINC00084, VINC |
| HGNC approved name | nuclear paraspeckle assembly transcript 1 |
| Entrez gene ID | GeneID:283131
(SSTAR profile) |
| HGNC gene family tag | # |
| HGNC gene family description | Long non-coding RNAs with non-systematic symbols |
| Function | Histone modifier recruitment |
| PMID for reference on function | PMID:31006037, PMID:31243262, PMID:31266852, PMID:27556296 |
| Target molecule type | RNA, Protein |
| Specific target | Paraspeckle proteins, MALAT1, EP300, CREBBP, STAT3,H3, EZH2 |
| Target UniProt ID | EP300_HUMAN, CBP_HUMAN, STAT3_HUMAN, EZH2_HUMAN |
| PMID for reference on targets and products | PMID:31006037, PMID:31243262, PMID:31266852, PMID:27556296 |
| Comment | A scaffold lncRNA of paraspeckles. Promotes breast and skin cancer growth. Is associated with P300/CBP complex and its inhibition affects H3K27Ac and H3K27Cro located nearby to the transcription start site of many genes, including endocytosis-related genes. Mediates the binding between STAT3 and H3K27Ac. Binds EZH2 and mediates H3K27me3 enrichment at the p21 promoter. Silences miR-129-5p expression by promoting the DNA methylation of the CpG island in the miR-129 gene. |
| Status of entry | New |