| Complex group name | ISWI |
| Complex name | ACF |
| Genes in complex | BAZ1A#65, SMARCA5#630 |
| Alternative names | ACF1-ISWI, ACF/WCRF |
| Proteins involved | BAZ1A, SMARCA5/SNF2H(ISWI-type ATPase) |
| Uniprot IDs of involved proteins | BAZ1A_HUMAN, SMCA5_HUMAN |
| PMID for reference on complex composition | PMID:10655480, PMID:25486562 |
| Function | chromatin remodeling complex |
| PMID for reference on function | PMID:12434153, PMID:14759371, PMID:17099699 |
| Target molecule type | chromatin |
| Specific target | pericentromeric chromatin |
| Product | # |
| Target UniProt ID | # |
| PMID for reference on targets and products | PMID:12434153 |
| Comment | Unfolding heterochromatin for replication. ATP-dependent chromatin remodeling complex, that regulates spacing of nucleosomes using ATP to generate evenly spaced nucleosomes along the chromatin. The ATPase activity of the complex is regulated by the length of flanking DNA. Also involved in facilitating the DNA replication process. BAZ1A is the accessory, non-catalytic subunit of the complex which can enhance and direct the process provided by the ATPase subunit, SMARCA5, probably through targeting pericentromeric heterochromatin in late S phase. Moves end-positioned nucleosomes to a predominantly central position. May have a role in nuclear receptor-mediated transcription repression. |
| Status of entry | # |