Complex group name | APOB mRNA editosome |
Complex name | APOB_mRNA_editosome |
Genes in complex | APOBEC1#24, APOBEC3F#30, APOBEC3G#31, APOBEC3H#32, A1CF#1, AICDA#12, SYNCRIP#673 |
Alternative names | Appoprotein B, APOBEC1, apolipoprotein B mRNA editing enzyme complex |
Proteins involved | A1CF, APOBEC3F, APOBEC3G, APOBEC3H, APOBEC1, AICDA, SYNCRIP |
Uniprot IDs of involved proteins | ABEC1_HUMAN, ABC3F_HUMAN, ABC3G_HUMAN, ABC3H_HUMAN, A1CF_HUMAN, AICDA_HUMAN, HNRPQ_HUMAN |
PMID for reference on complex composition | PMID:17121840 |
Function | mRNA editing complex |
PMID for reference on function | PMID:11727199 |
Target molecule type | mRNA, DNA |
Specific target | dC, mC |
Product | dU, T |
Target UniProt ID | # |
PMID for reference on targets and products | PMID:11727199 |
Comment | Responsible for the postranscriptional editing of a CAA codon for Gln to a UAA codon for stop in the APOB mRNA. Also involved in CGA (Arg) to UGA (Stop) editing in the NF1 mRNA. May also play a role in the epigenetic regulation of gene expression by participating in DNA demethylation. |
Status of entry | # |