| Complex group name | ISWI |
| Complex name | B-WICH |
| Genes in complex | BAZ1B#66, DDX21#170, DEK#173, ERCC6#215, MYBBP1A#416, MYO1C#417, SF3B1#612, SIRT7#624, SMARCA5#630 |
| Alternative names | WICH, WSTF-SNF2h, WSTF-ISWI |
| Proteins involved | BAZ1B/WSTF, DDX21, DEK, ERCC6, MYBBP1A, MYO1C, SF3B1, SIRT7, SMARCA5/SNF2H(ISWI-type ATPase) |
| Uniprot IDs of involved proteins | BAZ1B_HUMAN, DDX21_HUMAN, DEK_HUMAN, ERCC6_HUMAN, MBB1A_HUMAN, MYO1C_HUMAN, SF3B1_HUMAN, SIR7_HUMAN, SMCA5_HUMAN |
| PMID for reference on complex composition | PMID:16603771 |
| Function | histone phosphorylation complex, chromatin remodeling complex |
| PMID for reference on function | PMID:19092802, PMID:15753658 |
| Target molecule type | chromatin, histone |
| Specific target | H2AXY142 |
| Product | H2AXY142ph |
| Target UniProt ID | H2AX_HUMAN |
| PMID for reference on targets and products | PMID:19092802 |
| Comment | A chromatin remodeling complex that mobilizes nucleosomes and reconfigures irregular chromatin to a regular nucleosomal array structure. The WICH complex regulates the transcription of various genes, has a role in RNA polymerase I and RNA polymerase III transcription, mediates the histone H2AX phosphorylation at 'Tyr-142', and is involved in the maintenance of chromatin structures during DNA replication processes. H2AXY142ph plays a central role in DNA repair and acts as a mark that distinguishes between apoptotic and repair responses to genotoxic stress. |
| Status of entry | # |