Complex group name | PcG and PcG-like |
Complex name | BCOR |
Genes in complex | (BCOR#69|BCORL1#70), KDM2B#333, PCGF1#467, (RING1#568|RNF2#572), (RYBP#586|YAF2#771), SKP1#625, USP7#757 |
Alternative names | PRC1.1, RING2-KDM2B |
Proteins involved | BCOR/BCORL1, RYBP/YAF2, PCGF1, RING1 or RNF2/RING2, KDM2B, USP7 and SKP1 |
Uniprot IDs of involved proteins | (BCOR_HUMAN|BCORL_HUMAN), KDM2B_HUMAN, PCGF1_HUMAN, (RING1_HUMAN|RING2_HUMAN), (RYBP_HUMAN|YAF2_HUMAN), SKP1_HUMAN, UBP7_HUMAN |
PMID for reference on complex composition | PMID:16943429, PMID:22325352, PMID:24217316 |
Function | Polycomb like complex |
PMID for reference on function | PMID:16943429 |
Target molecule type | histone |
Specific target | H2AK119 |
Product | H2AK119ub1 |
Target UniProt ID | H2A1_HUMAN, H2A1A_HUMAN, H2A1B_HUMAN, H2A1C_HUMAN, H2A1D_HUMAN, H2A1H_HUMAN, H2A1J_HUMAN, H2A2A_HUMAN, H2A2B_HUMAN, H2A2C_HUMAN, H2A3_HUMAN, H2AB1_HUMAN, H2AB2_HUMAN, H2AJ_HUMAN, H2AV_HUMAN, H2AW_HUMAN, H2AX_HUMAN, H2AY_HUMAN, H2AZ_HUMAN |
PMID for reference on targets and products | # |
Comment | A complex required to maintain the transcriptionally repressive state of some genes, such as BCL6 and the cyclin-dependent kinase inhibitor, CDKN1A. |
Status of entry | # |