| Complex group name | DUB |
| Complex name | BRCA1-A |
| Genes in complex | BABAM1#60, BARD1#64, BRCA1#73, BRCC3#75, BRE#84, FAM175A#231, UIMC1#744 |
| Alternative names | # |
| Proteins involved | BRCA1, BARD1, UIMC1/RAP80, FAM175A/Abraxas, BRCC3/BRCC36, BRE/BRCC45 and BABAM1/NBA1 |
| Uniprot IDs of involved proteins | BABA1_HUMAN, BARD1_HUMAN, BRCA1_HUMAN, BRCC3_HUMAN, BRE_HUMAN, F175A_HUMAN, UIMC1_HUMAN |
| PMID for reference on complex composition | PMID:19261746, PMID:19261748, PMID:19261749 |
| Function | histone deubiquitination complex |
| PMID for reference on function | PMID:19261746, PMID:19261748, PMID:19261749 |
| Target molecule type | histone |
| Specific target | H2AK63ub, H2AXK63ub |
| Product | H2AK63, H2AXK63 |
| Target UniProt ID | H2A1_HUMAN, H2A1A_HUMAN, H2A1B_HUMAN, H2A1C_HUMAN, H2A1D_HUMAN, H2A1H_HUMAN, H2A1J_HUMAN, H2A2A_HUMAN, H2A2B_HUMAN, H2A2C_HUMAN, H2A3_HUMAN, H2AB1_HUMAN, H2AB2_HUMAN, H2AJ_HUMAN, H2AV_HUMAN, H2AW_HUMAN, H2AX_HUMAN, H2AY_HUMAN, H2AZ_HUMAN |
| PMID for reference on targets and products | PMID:19261746, PMID:19261748, PMID:19261749 |
| Comment | A complex that specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX. |
| Status of entry | # |