| Complex group name | MLL |
| Complex name | CHD8 |
| Genes in complex | ASH2L, C17orf49?, CHD8, DPY30, E2F6?, HCFC1?, HCFC2?, (HSPA1A | HSPA1B)?, INO80C?, KANSL1?, KAT8?, KDM6A?, KMT2A, LAS1L?, MAX?, MCRS1?, MEN1?, MGA?, NCOA6?, PAGR1?, PAXIP1?, PELP1?, PHF20?, PRPF31?, RBBP5, RNF2?, RUVBL1?, RUVBL2?, SENP3?, TAF1?, TAF4?, TAF6?, TAF7?, TAF9?, TEX10?, WDR5 |
| Alternative names | MLL1/MLL, CHD8 |
| Proteins involved | ASH2L, RBBP5, WDR5, DPY30, MLL and the facultative components PAGR1, BAP18, CHD8, E2F6, HCFC1, HCFC2, HSP70, INO80C, KDM6A, KANSL1, LAS1L, MAX, MCRS1, MEN1, MGA, KAT8/MOF, NCOA6, PAXIP1/PTIP, PELP1, PHF20, PRP31, RING2, RUVB1/TIP49A, RUVB2/TIP49B, SENP3, TAF1, TAF4, TAF6, TAF7, TAF9, TEX10 and alpha- and beta-tubulin |
| Uniprot IDs of involved proteins | ASH2L_HUMAN, BAP18_HUMAN?, CHD8_HUMAN, DPY30_HUMAN, E2F6_HUMAN?, HCFC1_HUMAN?, HCFC2_HUMAN?, HSP71_HUMAN?, IN80C_HUMAN?, KANL1_HUMAN?, KAT8_HUMAN?, KDM6A_HUMAN?, KMT2A_HUMAN, LAS1L_HUMAN?, MAX_HUMAN?, MCRS1_HUMAN?, MEN1_HUMAN?, MGAP_HUMAN?, NCOA6_HUMAN?, PAGR1_HUMAN?, PAXI1_HUMAN?, PELP1_HUMAN?, PHF20_HUMAN?, PRP31_HUMAN?, RBBP5_HUMAN, RING2_HUMAN?, RUVB1_HUMAN?, RUVB2_HUMAN?, SENP3_HUMAN?, TAF1_HUMAN?, TAF4_HUMAN?, TAF6_HUMAN?, TAF7_HUMAN?, TAF9_HUMAN?, TEX10_HUMAN?, WDR5_HUMAN |
| PMID for reference on complex composition | PMID:15960975, PMID:22108599 |
| Function | histone methylation complex, histone acetylation complex |
| PMID for reference on function | PMID:19556245 |
| Target molecule type | histone |
| Specific target | H3K4, H4K16 |
| Product | H3K4me, H4K16ac |
| Target UniProt ID | H31_HUMAN, H31T_HUMAN, H32_HUMAN, H33_HUMAN, H3C_HUMAN, H4_HUMAN |
| PMID for reference on targets and products | PMID:19556245 |
| Comment | A multiprotein complex that mediates both methylation of 'Lys-4' of histone H3 (H3K4me) complex and acetylation of 'Lys-16' of histone H4 (H4K16ac). |
| Status of entry | # |