| Complex group name | FACT |
| Complex name | FACT |
| Genes in complex | SSRP1#661, SUPT16H#664 |
| Alternative names | # |
| Proteins involved | SSRP1 and SUPT16H |
| Uniprot IDs of involved proteins | SSRP1_HUMAN, SP16H_HUMAN |
| PMID for reference on complex composition | PMID:10421373 |
| Function | chromatin remodeling complex |
| PMID for reference on function | PMID:16713563 |
| Target molecule type | chromatin, histone |
| Specific target | H2A, H2B |
| Product | # |
| Target UniProt ID | H2A1_HUMAN, H2A1A_HUMAN, H2A1B_HUMAN, H2A1C_HUMAN, H2A1D_HUMAN, H2A1H_HUMAN, H2A1J_HUMAN, H2A2A_HUMAN, H2A2B_HUMAN, H2A2C_HUMAN, H2A3_HUMAN, H2AB1_HUMAN, H2AB2_HUMAN, H2AJ_HUMAN, H2AV_HUMAN, H2AW_HUMAN, H2AX_HUMAN, H2AY_HUMAN, H2AZ_HUMAN, H2B1A_HUMAN, H2B1B_HUMAN, H2B1C_HUMAN, H2B1D_HUMAN, H2B1H_HUMAN, H2B1J_HUMAN, H2B1K_HUMAN, H2B1L_HUMAN, H2B1M_HUMAN, H2B1N_HUMAN, H2B1O_HUMAN, H2B2C_HUMAN, H2B2D_HUMAN, H2B2E_HUMAN, H2B2F_HUMAN, H2B3B_HUMAN, H2BFM_HUMAN, H2BFS_HUMAN, H2BWT_HUMAN |
| PMID for reference on targets and products | PMID:16713563 |
| Comment | A general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of the nucleosome following the passage of RNA polymerase II. The FACT complex is probably also involved in phosphorylation of 'Ser-392' of p53/TP53 via its association with CK2 (casein kinase II). |
| Status of entry | # |