| Complex group name | MLL |
| Complex name | MLL2/3 |
| Genes in complex | ASH2L#43, C17orf49#94?, CHD8#139?, DPY30#189, E2F6#193?, HCFC1#257?, HCFC2#258?, (HSPA1A#294|HSPA1B#296)?, INO80C#309?, KANSL1#320?, KAT8#329?, KDM6A#345?, (KMT2B#353|KMT2C#354)+, LAS1L#361?, MAX#369?, MCRS1#381?, MEN1#385?, MGA#392?, NCOA6#431?, PAGR1#458?, PAXIP1#464?, PELP1#474?, PHF20#485?, PRPF31#532?, RBBP5#548, RNF2#572?, RUVBL1#584?, RUVBL2#585?, SENP3#599?, TAF1#678?, TAF4#684?, TAF6#687?, TAF7#689?, TAF9#691?, TEX10#701?, WDR5#764 |
| Alternative names | ASCOM |
| Proteins involved | ASH2L, RBBP5, WDR5, DPY30, one or more specific histone methyltransferases (MLL2/ALR and MLL3), and the facultative components PAGR1, BAP18, CHD8, E2F6, HCFC1, HCFC2, HSP70, INO80C, KDM6A, KANSL1, LAS1L, MAX, MCRS1, MEN1, MGA, KAT8/MOF, NCOA6, PAXIP1/PTIP, PELP1, PHF20, PRP31, RING2, RUVB1/TIP49A, RUVB2/TIP49B, SENP3, TAF1, TAF4, TAF6, TAF7, TAF9, TEX10 and alpha- and beta-tubulin |
| Uniprot IDs of involved proteins | ASH2L_HUMAN, BAP18_HUMAN?, CHD8_HUMAN?, DPY30_HUMAN, E2F6_HUMAN?, HCFC1_HUMAN?, HCFC2_HUMAN?, HSP71_HUMAN?, IN80C_HUMAN?, KANL1_HUMAN?, KAT8_HUMAN?, KDM6A_HUMAN?, (KMT2B_HUMAN|KMT2C_HUMAN)+, LAS1L_HUMAN?, MAX_HUMAN?, MCRS1_HUMAN?, MEN1_HUMAN?, MGAP_HUMAN?, NCOA6_HUMAN?, PAGR1_HUMAN?, PAXI1_HUMAN?, PELP1_HUMAN?, PHF20_HUMAN?, PRP31_HUMAN?, RBBP5_HUMAN, RING2_HUMAN?, RUVB1_HUMAN?, RUVB2_HUMAN?, SENP3_HUMAN?, TAF1_HUMAN?, TAF4_HUMAN?, TAF6_HUMAN?, TAF7_HUMAN?, TAF9_HUMAN?, TEX10_HUMAN?, WDR5_HUMAN |
| PMID for reference on complex composition | PMID:17500065 |
| Function | histone methylation complex, histone acetylation complex |
| PMID for reference on function | PMID:17500065 |
| Target molecule type | histone |
| Specific target | H3K4 |
| Product | H3K4me3 |
| Target UniProt ID | # |
| PMID for reference on targets and products | PMID:21330447 |
| Comment | # |
| Status of entry | # |