| Complex group name | MLL |
| Complex name | MLL2/3 |
| Genes in complex | ASH2L, C17orf49?, CHD8?, DPY30, E2F6?, HCFC1?, HCFC2?, (HSPA1A | HSPA1B)?, INO80C?, KANSL1?, KAT8?, KDM6A?, (KMT2B | KMT2C)+, LAS1L?, MAX?, MCRS1?, MEN1?, MGA?, NCOA6?, PAGR1?, PAXIP1?, PELP1?, PHF20?, PRPF31?, RBBP5, RNF2?, RUVBL1?, RUVBL2?, SENP3?, TAF1?, TAF4?, TAF6?, TAF7?, TAF9?, TEX10?, WDR5 |
| Alternative names | ASCOM |
| Proteins involved | ASH2L, RBBP5, WDR5, DPY30, one or more specific histone methyltransferases (MLL2/ALR and MLL3), and the facultative components PAGR1, BAP18, CHD8, E2F6, HCFC1, HCFC2, HSP70, INO80C, KDM6A, KANSL1, LAS1L, MAX, MCRS1, MEN1, MGA, KAT8/MOF, NCOA6, PAXIP1/PTIP, PELP1, PHF20, PRP31, RING2, RUVB1/TIP49A, RUVB2/TIP49B, SENP3, TAF1, TAF4, TAF6, TAF7, TAF9, TEX10 and alpha- and beta-tubulin |
| Uniprot IDs of involved proteins | ASH2L_HUMAN, BAP18_HUMAN?, CHD8_HUMAN?, DPY30_HUMAN, E2F6_HUMAN?, HCFC1_HUMAN?, HCFC2_HUMAN?, HSP71_HUMAN?, IN80C_HUMAN?, KANL1_HUMAN?, KAT8_HUMAN?, KDM6A_HUMAN?, (KMT2B_HUMAN | KMT2C_HUMAN)+, LAS1L_HUMAN?, MAX_HUMAN?, MCRS1_HUMAN?, MEN1_HUMAN?, MGAP_HUMAN?, NCOA6_HUMAN?, PAGR1_HUMAN?, PAXI1_HUMAN?, PELP1_HUMAN?, PHF20_HUMAN?, PRP31_HUMAN?, RBBP5_HUMAN, RING2_HUMAN?, RUVB1_HUMAN?, RUVB2_HUMAN?, SENP3_HUMAN?, TAF1_HUMAN?, TAF4_HUMAN?, TAF6_HUMAN?, TAF7_HUMAN?, TAF9_HUMAN?, TEX10_HUMAN?, WDR5_HUMAN |
| PMID for reference on complex composition | PMID:17500065 |
| Function | histone methylation complex, histone acetylation complex |
| PMID for reference on function | PMID:17500065 |
| Target molecule type | histone |
| Specific target | H3K4 |
| Product | H3K4me3 |
| Target UniProt ID | # |
| PMID for reference on targets and products | PMID:21330447 |
| Comment | # |
| Status of entry | # |