Complex group name | Mis18 |
Complex name | Mis18 |
Genes in complex | MIS18A#395, OIP5#452, MIS18BP1#396 |
Alternative names | # |
Proteins involved | MIS18A, OIP5, MIS18BP1 |
Uniprot IDs of involved proteins | MS18A_HUMAN, MS18B_HUMAN, M18BP_HUMAN |
PMID for reference on complex composition | PMID:22516971 |
Function | Chromatin remodeling |
PMID for reference on function | PMID:22516971, PMID:26942680 |
Target molecule type | histone |
Specific target | CENPA |
Product | # |
Target UniProt ID | # |
PMID for reference on targets and products | PMID:22516971 |
Comment | Regulates CENPA recruitment to centromeres and thereby normal chromosome segregation during mitosis. Interacts with DNMT3A/3B and provides it`s centromeric localization regulating epigenetic states of centromeric chromatin. Provides access of CENPA-specific chaperone HJURP to centromeres. |
Status of entry | New |