| Complex group name | SWI/SNF |
| Complex name | npBAF |
| Genes in complex | ACTL6A#4, ACTB#3, (ARID1A#33|ARID1B#34), SMARCA2#628, SMARCA4#629, SMARCE1#639, SMARCC1#634, SMARCC2#635, SMARCD1#636, SMARCD3#638, SMARCB1#633, PHF10#479 |
| Alternative names | neural progenitors-specific chromatin remodeling complex, BAF53 |
| Proteins involved | ARID1A/BAF250A or ARID1B/BAF250B, SMARCD1/BAF60A, SMARCD3/BAF60C, SMARCA2/BRM/BAF190B, SMARCA4/BRG1/BAF190A, SMARCB1/BAF47, SMARCC1/BAF155, SMARCE1/BAF57, SMARCC2/BAF170, PHF10/BAF45A, ACTL6A/BAF53A and actin |
| Uniprot IDs of involved proteins | ACL6A_HUMAN, ACTB_HUMAN, (ARI1A_HUMAN|ARI1B_HUMAN), SMCA2_HUMAN, SMCA4_HUMAN, SMCE1_HUMAN, SMRC1_HUMAN, SMRC2_HUMAN, SMRD1_HUMAN, SMRD3_HUMAN, SNF5_HUMAN, PHF10_HUMAN |
| PMID for reference on complex composition | PMID:10078207, PMID:11078522, PMID:18765789, by similarity |
| Function | chromatin remodeling complex |
| PMID for reference on function | PMID:11078522 |
| Target molecule type | chromatin |
| Specific target | # |
| Product | # |
| Target UniProt ID | # |
| PMID for reference on targets and products | # |
| Comment | Neural progenitors-specific chromatin remodeling complex. The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. During neural development a switch from a stem/progenitor to a post-mitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to post-mitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. |
| Status of entry | # |