| HGNC approved symbol | HGNC ID | HGNC approved name | Entrez gene ID | UniProt AC (human) | UniProt ID (human) | Pfam domains | MGI symbol | MGI ID | UniProt AC (mouse) | UniProt ID (mouse) | HGNC gene family tag | HGNC gene family description | Function | Modification | PMID for information on function | Protein complex | Target molecule | Target entity | Product | PMID for information on target | Comment | Status of entry |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
BRCA2
(details) |
1101 | breast cancer 2, early onset | 675 | P51587 | BRCA2_HUMAN | BRCA2 PF00634 1002-1036 1216-1244 1424-1452 1521-1548 1665-1847 1842-1867 1974-2003 2054-2083, BRCA-2_helical PF09169 2476-2667, BRCA-2_OB1 PF09103 2669-2798, BRCA2DBD_OB2 PF21318 2804-2863 2969-3034, Tower PF09121 2831-2868, BRCA-2_OB3 PF09104 3053-3189, domain PF22687 3270-3382 | Brca2 | 109337 | P97929 | BRCA2_MOUSE | FANC | Fanconi anemia, complementation groups | Histone modification write | Histone acetylation | 9619837 | BRCC | histone, DNA | H3, H4, ssDNA | # | 9619837 | BRCA2 proteins acetylate primarily H3 and H4 of free histones. This suggests that HAT activity of BRCA2 may play an important role in the regulation of transcription and tumor suppressor function. | # |
|
BRCC3
(details) |
24185 | BRCA1/BRCA2-containing complex, subunit 3 | 79184 | P46736 | BRCC3_HUMAN | JAB PF01398 8-147, BRCC36_C PF18110 226-308 | Brcc3 | 2389572 | P46737 | BRCC3_MOUSE | # | # | Histone modification erase | Histone deubiquitination | 19202061 | BRISC, BRCA1-A | histone | H2AK63, H2AXK63 | H2A, H2AX | 19202061 | Involved in DNA damage response and reverses RNF8 ubiquitination activity. Rap80-BRCC36 DUB Activity and γH2AX hydrolysis Ubiquitination. Rap80 is required for BRCA1 and BRCC36 localization to DSBs. | # |
|
SMARCA2
(details) |
11098 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2 | 6595 | P51531 | SMCA2_HUMAN | QLQ PF08880 174-208, HSA PF07529 438-508, BRK PF07533 591-633, SNF2-rel_dom PF00176 727-1021, Helicase_C PF00271 1051-1164, SnAC PF14619 1259-1326, Bromodomain PF00439 1421-1489 | Smarca2 | 99603 | Q6DIC0 | SMCA2_MOUSE | # | # | Histone modification read, TF | TF activator | 22464331 | BAF, nBAF, npBAF, WINAC, bBAF, SWI/SNF BRM-BRG1 | histone, DNA | H3, DNA motif | # | 22464331 | Fig. 5 in the reference. | # |