| HGNC approved symbol | HGNC ID | HGNC approved name | Entrez gene ID | UniProt AC (human) | UniProt ID (human) | Pfam domains | MGI symbol | MGI ID | UniProt AC (mouse) | UniProt ID (mouse) | HGNC gene family tag | HGNC gene family description | Function | Modification | PMID for information on function | Protein complex | Target molecule | Target entity | Product | PMID for information on target | Comment | Status of entry |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
ACTL6A
(details) |
24124 | actin-like 6A | 86 | O96019 | ACL6A_HUMAN | Actin PF00022 10-428 | Actl6a | 1861453 | Q9Z2N8 | ACL6A_MOUSE | INO80 | INO80 complex subunits | Chromatin remodeling cofactor | # | 9845365 | BAF, npBAF, PBAF, SWI/SNF_Brg1(I), SWI/SNF_Brg1(II), SWI/SNF_Brm, SWI/SNF-like_EPAFa, WINAC, SWI/SNF-like EPAFB, SWI/SNF BRM-BRG1, Ino80, NuA4, NuA4-related complex, SRCAP | chromatin | # | # | 9845365 | β-actin and BAF53 =ACTL6A are required for maximal ATPase activity of BRG1 and are also required with BRG1 for association of the complex with chromatin/matrix. | # |
|
ARNTL
(details) |
701 | aryl hydrocarbon receptor nuclear translocator-like | 406 | O00327 | BMAL1_HUMAN | HLH PF00010 74-126, PAS PF00989 149-254, PAS_11 PF14598 339-442 | Arntl | 1096381 | Q9WTL8 | BMAL1_MOUSE | bHLH | Basic helix-loop-helix proteins | Histone modification write cofactor, TF | TF activator | 14645221, 24395244 | # | histone | # | # | 14645221, 24395244 | The coincidence of a rhythm in histone H3 and histone H4 acetylation on the proximal E-box of hPer1 with transcriptional activation of per1 and per2 is consistent with the heterodimeric complexes of CLOCK, NPAS2 and BMAL1 = ARNTL recruiting a histone acetyltransferase (HAT)-containing transcriptional co-activation complex to achieve maximal target gene activation; CLOCK:BMAL1 functions like pioneer transcription factors and regulates the DNA accessibility of other transcription factors. | # |
|
MAX
(details) |
6913 | MYC associated factor X | 4149 | P61244 | MAX_HUMAN | HLH PF00010 24-74 | Max | 96921 | P28574 | MAX_MOUSE | bHLH | Basic helix-loop-helix proteins | Histone modification write cofactor, TF | Histone methylation, Histone acetylation, TF activator, TF repressor | 18271930, 12004135 | CHD8, MLL2/3, MLL4/WBP7 | DNA | DNA motif | # | 18271930, 12004135 | Part of a multimeric protein complex that contains E2F6, Mga and Max. The complex contains chromatin modifiers such as a novel histone methyltransferase that modifies lysine 9 of histone H3, HP1gamma, and Polycomb group (PcG) proteins. | # |
|
MGA
(details) |
14010 | MGA, MAX dimerization protein | 23269 | Q8IWI9 | MGAP_HUMAN | T-box PF00907 77-259, MGA_dom PF16059 1043-1085, HLH PF00010 2425-2474 | Mga | 1352483 | A2AWL7 | MGAP_MOUSE | # | # | Histone modification write cofactor, TF | Histone methylation, Histone acetylation, TF activator, TF repressor | # | RING2-L3MBTL2, CHD8, MLL2/3, MLL4/WBP7 | DNA | DNA motif | # | # | Added because it is a complex partner | # |