| HGNC approved symbol | HGNC ID | HGNC approved name | Entrez gene ID | UniProt AC (human) | UniProt ID (human) | Pfam domains | MGI symbol | MGI ID | UniProt AC (mouse) | UniProt ID (mouse) | HGNC gene family tag | HGNC gene family description | Function | Modification | PMID for information on function | Protein complex | Target molecule | Target entity | Product | PMID for information on target | Comment | Status of entry |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
ATXN7
(details) |
10560 | ataxin 7 | 6314 | O15265 | ATX7_HUMAN | SCA7 PF08313 332-395 | Atxn7 | 2179277 | Q8R4I1 | ATX7_MOUSE | ATXN | Ataxins | Histone modification write cofactor | Histone acetylation | 16494529 | SAGA | histone | # | # | 16494529 | Ataxin-7 (ATXN7) is a subunit of the GCN5 histone acetyltransferase–containing coactivator complexes TFTC/STAGA. TFTC/STAGA complexes purified from SCA7 mice have normal TRRAP, GCN5, TAF12, and SPT3 levels and that their histone or nucleosomal acetylation activities are unaffected. | # |
|
TAF1
(details) |
11535 | TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 250kDa | 6872 | P21675 | TAF1_HUMAN | TBP-binding PF09247 27-87, DUF3591 PF12157 589-1050, zf-CCHC_6 PF15288 1282-1324, Bromodomain PF00439 1411-1492 1538-1613 | Taf1 | 1336878 | Q80UV9 | TAF1_MOUSE | KAT | Chromatin-modifying enzymes / K-acetyltransferases | Histone modification write | Histone acetylation | 11295558 | CHD8, MLL2/3, MLL4/WBP7 | histone | H3, H4 | H3ac, H4ac | 11295558 | TAFII250 has histone acetyltransferase (HAT) activity and can acetylate the tails of the core histones H3 and H4 in vitro. Both the N- and C-terminal kinase domains of TAFII250 are required for efficient transphosphorylation of RAP74 on serine residues. This suggests that the targeted phosphorylation of RAP74 by TAFII250 may provide a mechanism for signaling between components within the initiation complex to regulate transcription. | # |
|
TAF10
(details) |
11543 | TAF10 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 30kDa | 6881 | Q12962 | TAF10_HUMAN | TFIID_30kDa PF03540 128-177 | Taf10 | 1346320 | Q8K0H5 | TAF10_MOUSE | # | # | Histone chaperone, Histone modification write | Histone acetylation | 15099517 | PCAF, TFTC-HAT, SAGA, STAGA | histone | H3, H4 | # | 15099517 | SET9 can monomethylate the TBP-associated factor TAF10 at a single lysine residue located at the loop 2 region within the putative histone-fold domain of the protein. | # |
|
TAF12
(details) |
11545 | TAF12 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 20kDa | 6883 | Q16514 | TAF12_HUMAN | TFIID_20kDa PF03847 59-126 | Taf12 | 1913714 | Q8VE65 | TAF12_MOUSE | # | # | Histone chaperone, Histone modification write | Histone acetylation | 10594036 | PCAF, STAGA | histone | # | # | 10594036 | Heterodimerization requires the alpha2 and alpha3 helices of the hTAF(II)20 histone fold and is abolished by mutations in the hydrophobic face of the hTAF(II)20 alpha2 helix. Interaction with hTAF(II)20 requires a domain of hTAF(II)135 which shows sequence homology to H2A. | # |
|
TAF1L
(details) |
18056 | TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 210kDa-like | 138474 | Q8IZX4 | TAF1L_HUMAN | TBP-binding PF09247 26-86, DUF3591 PF12157 583-1047, zf-CCHC_6 PF15288 1278-1322, Bromodomain PF00439 1409-1488 1536-1612 | # | # | # | # | # | # | Histone modification read | # | 22464331 | # | histone | H1.4ac, H2Aac, H2Bac, H3ac, H4ac | # | 22464331 | Interacts (via bromo domains) with acetylated lysine residues on the N-terminus of histone H1.4, H2A, H2B, H3 and H4 (in vitro). | # |
|
TAF7
(details) |
11541 | TAF7 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 55kDa | 6879 | Q15545 | TAF7_HUMAN | TAFII55_N PF04658 13-176 | Taf7 | 1346348 | Q9R1C0 | TAF7_MOUSE | # | # | Histone modification write cofactor, Histone modification write cofactor | Histone methylation, Histone acetylation | 22711989 | CHD8, MLL2/3, MLL4/WBP7 | histone | # | # | 22711989 | The largest transcription factor IID (TFIID) subunit, TBP-associated factor 1 (TAF1), possesses protein kinase and histone acetyltransferase (HAT) activities. | # |
|
TAF8
(details) |
17300 | TAF8 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 43kDa | 129685 | Q7Z7C8 | TAF8_HUMAN | Bromo_TP PF07524 32-105, TAF8_C PF10406 146-195 | Taf8 | 1926879 | Q9EQH4 | TAF8_MOUSE | # | # | Histone chaperone | # | 17375202 | # | histone | # | # | 17375202 | Present in a small TAF complex (SMAT), containing TAF8, TAF10 and SPT7L. | # |