| HGNC approved symbol | HGNC ID | HGNC approved name | Entrez gene ID | UniProt AC (human) | UniProt ID (human) | Pfam domains | MGI symbol | MGI ID | UniProt AC (mouse) | UniProt ID (mouse) | HGNC gene family tag | HGNC gene family description | Function | Modification | PMID for information on function | Protein complex | Target molecule | Target entity | Product | PMID for information on target | Comment | Status of entry |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
KDM4D
(details) |
25498 | lysine (K)-specific demethylase 4D | 55693 | Q6B0I6 | KDM4D_HUMAN | JmjN PF02375 19-53, JmjC PF02373 179-295 | Kdm4d | 3606484 | Q3U2K5 | KDM4D_MOUSE | KDM | Chromatin-modifying enzymes / K-demethylases | Histone modification erase | Histone methylation | 16603238 | # | histone | H3K9me3 | H3K9me1, H3K9me2 | 16603238 | Human JMJD2(B, C, D) =KDM4(B, C, D) subfamily members function as trimethylation-specific demethylases, converting H3-K9Me3 to H3-K9Me2 and H3-K9Me1, respectively. | # |
|
KDM4E
(details) |
37098 | lysine (K)-specific demethylase 4E | 390245 | B2RXH2 | KDM4E_HUMAN | JmjN PF02375 16-50, JmjC PF02373 176-292 | # | # | # | # | KDM | Chromatin-modifying enzymes / K-demethylases | Histone modification erase | Histone methylation | 21914792 | # | histone | H3K9me2, H3K9me3 | H3K9 | 21914792 | KDM4D and KDM4E (which is catalytically active) catalyze demethylation of H3K9me3/me2. | # |