| HGNC approved symbol | HGNC ID | HGNC approved name | Entrez gene ID | UniProt AC (human) | UniProt ID (human) | Pfam domains | MGI symbol | MGI ID | UniProt AC (mouse) | UniProt ID (mouse) | HGNC gene family tag | HGNC gene family description | Function | Modification | PMID for information on function | Protein complex | Target molecule | Target entity | Product | PMID for information on target | Comment | Status of entry |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
CELF2
(details) |
2550 | CUGBP Elav-like family member 2 (CELF-2) (Bruno-like protein 3) (CUG triplet repeat RNA-binding protein 2) (CUG-BP2) (CUG-BP- and ETR-3-like factor 2) (ELAV-type RNA-binding protein 3) (ETR-3) (Neuroblastoma apoptosis-related RNA-binding protein) (hNAPOR) (RNA-binding protein BRUNOL-3) | 10659 | O95319 | CELF2_HUMAN | RRM_1 PF00076 43-110 134-198 425-495 | Celf2 | 1338822 | Q9Z0H4 | CELF2_MOUSE | RBM | RNA binding motif containing | RNA modification | Alternative splicing | 11158314, 12649496 | # | RNA | mRNA | # | 11158314, 12649496 | Regulates MSE-dependent alternative splicing of cTNT during development in vertebrates. | New |
|
CHTOP
(details) |
24511 | chromatin target of PRMT1 | 26097 | Q9Y3Y2 | CHTOP_HUMAN | FoP_duplication PF13865 167-243 | Chtop | 1913761 | Q9CY57 | CHTOP_MOUSE | # | # | # | # | 25284789 | # | DNA | # | # | # | 5-Hydroxymethylcytosine plays a critical role in glioblastomagenesis by recruiting the CHTOP-methylosome complex. | # |
|
KDM5A
(details) |
9886 | lysine (K)-specific demethylase 5A | 5927 | P29375 | KDM5A_HUMAN | JmjN PF02375 20-53, ARID PF01388 86-170, PHD PF00628 296-340 1164-1215, JmjC PF02373 470-586, KDM5_C-hel PF21323 590-644, zf-C5HC2 PF02928 676-728, PLU-1 PF08429 741-1070 | Kdm5a | 2136980 | Q3UXZ9 | KDM5A_MOUSE | KDM, PHF | Chromatin-modifying enzymes / K-demethylases, Zinc fingers, PHD-type | Histone modification erase | Histone methylation | 17320163 | # | histone | H3K4me3 | H3K4 | 17320163 | The retinoblastoma binding protein RBP2 =KDM5A is an H3K4 demethylase. | # |
|
RB1
(details) |
9884 | retinoblastoma 1 | 5925 | P06400 | RB_HUMAN | DUF3452 PF11934 110-229, RB_A PF01858 375-573, RB_B PF01857 647-765, Rb_C PF08934 768-925 | Rb1 | 97874 | P13405 | RB_MOUSE | ENDOLIG | Endogenous ligands | Chromatin remodeling, Histone modification write | Histone ubiquitination | 19149898 | CREST-BRG1, L3MBTL1 | histone | # | # | 19149898 | Hypophosphorylated pRb can repress gene transcription at least partly by remodeling chromatin structure through its interactions with proteins such as HDAC1, BRM and BRG1. | # |
|
RBBP4
(details) |
9887 | retinoblastoma binding protein 4 | 5928 | Q09028 | RBBP4_HUMAN | CAF1C_H4-bd PF12265 19-88, WD40 PF00400 173-206 221-256 265-302 309-346 367-402 | Rbbp4 | 1194912 | Q60972 | RBBP4_MOUSE | WDR | WD repeat domain containing | Histone chaperone | # | 8858152 | NuRF, SWI/SNF_Brg1(I), SWI/SNF_Brg1(II), SWI/SNF_Brm, NuRD, mSin3A, core HDAC, mSin3A-like complex, PRC2, CAF-1 | histone | H4 | # | 8858152 | RbAp46 and RbAp48 (pRB-associated proteins p46 and p48, also known as RBBP7 and RBBP4, respectively) are highly homologous histone chaperones that play key roles in establishing and maintaining chromatin structure. Human p48 =RBBP4 can bind to histone H4 in the absence of CAF-1 p150 and p60. p48, also a known subunit of a histone deacetylase, copurifies with a chromatin assembly complex (CAC), which contains the three subunits of CAF-1 (p150, p60, p48) and H3 and H4, and promotes DNA replication-dependent chromatin assembly. | # |
|
RBBP5
(details) |
9888 | retinoblastoma binding protein 5 | 5929 | Q15291 | RBBP5_HUMAN | WD40 PF00400 29-52 62-94 | Rbbp5 | 1918367 | Q8BX09 | RBBP5_MOUSE | WDR | WD repeat domain containing | Histone modification write cofactor | Histone methylation | 19556245 | COMPASS, Menin-associated_HMT, MLL-HCF, CHD8, MLL2/3, COMPASS-like MLL1,2, MLL4/WBP7, COMPASS-like MLL3,4 | histone | H3K4 | H3K4me1, H3K4me2, H3K4me3 | 19556245 | A five-component 200-kDa MLL1 core complex containing human MLL1, WDR5, RbBP5, Ash2L, and DPY-30. | # |
|
RBBP7
(details) |
9890 | retinoblastoma binding protein 7 | 5931 | Q16576 | RBBP7_HUMAN | CAF1C_H4-bd PF12265 18-87, WD40 PF00400 172-205 220-255 264-301 308-345 366-402 | Rbbp7 | 1194910 | Q60973 | RBBP7_MOUSE | WDR | WD repeat domain containing | Histone chaperone | # | 18571423 | NuRF, NuRD, mSin3A, core HDAC, mSin3A-like complex, PRC2 | histone | H4 | # | 18571423 | RbAp46 and RbAp48 (pRB-associated proteins p46 and p48, also known as RBBP7 and RBBP4, respectively) are highly homologous histone chaperones that play key roles in establishing and maintaining chromatin structure. When a histone H3/H4 dimer (or tetramer) binds to RbAp46 or RbAp48, helix 1 of histone H4 unfolds to interact with the histone chaperone. | # |
|
SRRM4
(details) |
29389 | Serine/arginine repetitive matrix protein 4 (Medulloblastoma antigen MU-MB-2.76) (Neural-specific serine/arginine repetitive splicing factor of 100 kDa) (Neural-specific SR-related protein of 100 kDa) (nSR100) | 84530 | A7MD48 | SRRM4_HUMAN | SRRM_C PF15230 459-521 | Srrm4 | 1916205 | Q8BKA3 | SRRM4_MOUSE | # | # | RNA modification | Alternative splicing | 29961578 | # | RNA | mRNA | # | 29961578 | Regulates alternative splicing events in genes with important neuronal functions | New |