| HGNC approved symbol | HGNC ID | HGNC approved name | Entrez gene ID | UniProt AC (human) | UniProt ID (human) | Pfam domains | MGI symbol | MGI ID | UniProt AC (mouse) | UniProt ID (mouse) | HGNC gene family tag | HGNC gene family description | Function | Modification | PMID for information on function | Protein complex | Target molecule | Target entity | Product | PMID for information on target | Comment | Status of entry |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
TP53
(details) |
11998 | tumor protein p53 | 7157 | P04637 | P53_HUMAN | P53_TAD PF08563 13-33, TAD2 PF18521 23-55, P53 PF00870 101-288, P53_tetramer PF07710 323-357 | Trp53 | 98834 | P02340 | P53_MOUSE | # | # | Histone modification write cofactor, TF | Histone acetylation, TF activator, TF repressor | 23870121 | # | histone | H3 | # | 23870121 | SET1 complex (SET1C)-mediated H3K4 trimethylation is dependent upon p53- and p300-mediated H3 acetylation. Complementary cell-based assays demonstrate a DNA-damage-induced p53-SET1C interaction, a corresponding enrichment of SET1C and H3K4me3 on a p53 target gene (p21/WAF1), and a corresponding codependency of H3K4 trimethylation and transcription upon p300 and SET1C. | # |
|
TP53BP1
(details) |
11999 | tumor protein p53 binding protein 1 | 7158 | Q12888 | TP53B_HUMAN | 53-BP1_Tudor PF09038 1481-1604, BRCT_3 PF18428 1866-1968 | Trp53bp1 | 1351320 | P70399 | TP53B_MOUSE | # | # | Histone modification read | # | 15525939 | # | histone | H4K79me2, H4K20me2 | # | 15525939 | In vitro, the 53BP1 =TP53BP1 tandem tudor domain binds histone H3 methylated on Lys 79 using residues that form the walls of the pocket; these residues are also required for recruitment of 53BP1 to DSBs. | # |