Gene info
| HGNC approved symbol | TP53 |
| HGNC ID | HGNC:11998 |
| HGNC approved name | tumor protein p53 |
| Entrez gene ID | GeneID:7157 (SSTAR profile) |
| UniProt AC (human) | P04637 |
| UniProt ID (human) | P53_HUMAN |
| Pfam domains | P53_TAD PF08563 (13-33) TAD2 PF18521 (23-55) P53 PF00870 (101-288) P53_tetramer PF07710 (323-357) |
| MGI symbol | Trp53 |
| MGI ID | MGI:98834 |
| UniProt AC (mouse) | P02340 |
| UniProt ID (mouse) | P53_MOUSE |
| HGNC gene family tag | # |
| HGNC gene family description | # |
| Function | Histone modification write cofactor, TF |
| Modification | Histone acetylation, TF activator, TF repressor |
| PMID for information on function | PMID:23870121 |
| Protein complex | # |
| Target molecule | histone |
| Target entity | H3 |
| HOCOMOCO TFBS model | |
| Product | # |
| PMID for information on target | PMID:23870121 |
| Comment | SET1 complex (SET1C)-mediated H3K4 trimethylation is dependent upon p53- and p300-mediated H3 acetylation. Complementary cell-based assays demonstrate a DNA-damage-induced p53-SET1C interaction, a corresponding enrichment of SET1C and H3K4me3 on a p53 target gene (p21/WAF1), and a corresponding codependency of H3K4 trimethylation and transcription upon p300 and SET1C. |
| Status of entry | # |
Expression statistics
| Expression range: | 0.0 to 325.54 |
| Mean expression: | 50.22 ± 42.08 |
| Median expression: | 38.93 |