| HGNC approved symbol | HGNC ID | HGNC approved name | Entrez gene ID | UniProt AC (human) | UniProt ID (human) | Pfam domains | MGI symbol | MGI ID | UniProt AC (mouse) | UniProt ID (mouse) | HGNC gene family tag | HGNC gene family description | Function | Modification | PMID for information on function | Protein complex | Target molecule | Target entity | Product | PMID for information on target | Comment | Status of entry |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
CHTOP
(details) |
24511 | chromatin target of PRMT1 | 26097 | Q9Y3Y2 | CHTOP_HUMAN | FoP_duplication PF13865 167-243 | Chtop | 1913761 | Q9CY57 | CHTOP_MOUSE | # | # | # | # | 25284789 | # | DNA | # | # | # | 5-Hydroxymethylcytosine plays a critical role in glioblastomagenesis by recruiting the CHTOP-methylosome complex. | # |
|
PRMT1
(details) |
5187 | protein arginine methyltransferase 1 | 3276 | Q99873 | ANM1_HUMAN | Methyltransf_25 PF13649 92-189, domain PF22528 194-358 | Prmt1 | 107846 | Q9JIF0 | ANM1_MOUSE | PRMT | Protein arginine methyltransferases | Histone modification write | Histone methylation | 11387442 | # | histone | H4R3 | H4R3me1, H4R3me2a | 11387442 | PRMT1 specifically methylates arginine 3 (Arg 3) of H4 in vitro and in vivo. Methylation of Arg 3 by PRMT1 facilitates subsequent acetylation of H4 tails by p300. | # |
|
PRMT2
(details) |
5186 | protein arginine methyltransferase 2 | 3275 | P55345 | ANM2_HUMAN | SH3_1 PF00018 36-82, MTS PF05175 131-210, domain PF22528 244-415 | Prmt2 | 1316652 | Q9R144 | ANM2_MOUSE | PRMT | Protein arginine methyltransferases | Histone modification write | Histone methylation | 19405910 | # | histone | H4 | H4me | 19405910 | PRMT2 activity is substantially lower than PRMT1 in vitro, but both enzymes selectively methylate histone H4 and PRMT2, like PRMT1, may act as a transcription co-activator through this modification. | # |
|
PRMT8
(details) |
5188 | protein arginine methyltransferase 8 | 56341 | Q9NR22 | ANM8_HUMAN | PrmA PF06325 111-184, domain PF22528 217-380 | Prmt8 | 3043083 | Q6PAK3 | ANM8_MOUSE | PRMT | Protein arginine methyltransferases | Histone modification write | Histone methylation | 16051612 | # | histone | H4R | H4Rme | 16051612 | PRMT8 preferentially methylates histone H4 and the recombinant forms of GAR and Npl3, thus displaying PRMT1-like substrate specificity. | # |
|
PRMT9
(details) |
25099 | protein arginine methyltransferase 9 | 90826 | Q6P2P2 | ANM9_HUMAN | PrmA PF06325 175-235, domain PF22528 366-461 750-837 | Prmt10 | 2142651 | Q3U3W5 | ANM9_MOUSE | PRMT | Protein arginine methyltransferases | Histone modification write | Histone methylation | 18007657 | # | histone | H4R3 | H4R3me2 | 18007657 | Arabidopsis thaliana protein arginine methyltransferase 10 (AtPRMT10)--the Arabidopsis homologue of PHRMT10 (=PRMT9)--has been shown to be a type I PRMT, which preferentially asymmetrically methylated histone H4R3 in vitro. Belongs to SAM-binding ethyltransferase superfamily. | # |