| HGNC approved symbol | HGNC ID | HGNC approved name | Entrez gene ID | UniProt AC (human) | UniProt ID (human) | Pfam domains | MGI symbol | MGI ID | UniProt AC (mouse) | UniProt ID (mouse) | HGNC gene family tag | HGNC gene family description | Function | Modification | PMID for information on function | Protein complex | Target molecule | Target entity | Product | PMID for information on target | Comment | Status of entry |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
DPY30
(details) |
24590 | dpy-30 homolog (C. elegans) | 84661 | Q9C005 | DPY30_HUMAN | Dpy-30 PF05186 52-92 | Dpy30 | 1913560 | Q99LT0 | DPY30_MOUSE | # | # | Histone modification write cofactor | Histone methylation | 19556245 | COMPASS, Menin-associated_HMT, MLL-HCF, CHD8, MLL2/3, COMPASS-like MLL1,2, MLL4/WBP7, COMPASS-like MLL3,4 | histone | # | # | 19556245 | The isolated MLL1 SET domain is an H3K4 monomethyltransferase. When the MLL1 SET domain fragment is assembled with a complex containing WDR5, RbBP5, Ash2L, and DPY-30, the rate of lysine methylation is dramatically increased, but only to the dimethyl form of H3K4, suggesting that the MLL1 core complex is predominantly a dimethyltransferase. | # |
|
MBIP
(details) |
20427 | MAP3K12 binding inhibitory protein 1 | 51562 | Q9NS73 | MBIP1_HUMAN | Mbip | 1918320 | Q99LQ1 | MBIP1_MOUSE | # | # | Histone modification write cofactor | Histone acetylation | 19103755 | ATAC | histone | # | # | 19103755 | Novel proteins identified as STAGA/ TFTC subunits, such as ATAC2, DR1, MBIP, WDR5, YEATS2, and ZZZ3/ATAC1. | # | |
|
NCOA6
(details) |
15936 | nuclear receptor coactivator 6 | 23054 | Q14686 | NCOA6_HUMAN | NCOA6_TRADD-N PF13820 47-182 | Ncoa6 | 1929915 | Q9JL19 | NCOA6_MOUSE | # | # | Histone modification write cofactor | Histone methylation | 17500065 | CHD8, MLL2/3, COMPASS-like MLL3,4 | histone | # | # | 17500065 | Ectopically expressed PTIP is capable of interacting with DNA damage response proteins including 53BP1, while endogenous PTIP, and a novel protein PA1 are both components of a Set1-like histone methyltransferase (HMT) complex that also contains ASH2L, RBBP5, WDR5, hDPY-30, NCOA6, SET domain-containing HMTs MLL3 and MLL4, and substoichiometric amount of JmjC domain-containing putative histone demethylase UTX. | # |
|
RBBP5
(details) |
9888 | retinoblastoma binding protein 5 | 5929 | Q15291 | RBBP5_HUMAN | WD40 PF00400 29-52 62-94 | Rbbp5 | 1918367 | Q8BX09 | RBBP5_MOUSE | WDR | WD repeat domain containing | Histone modification write cofactor | Histone methylation | 19556245 | COMPASS, Menin-associated_HMT, MLL-HCF, CHD8, MLL2/3, COMPASS-like MLL1,2, MLL4/WBP7, COMPASS-like MLL3,4 | histone | H3K4 | H3K4me1, H3K4me2, H3K4me3 | 19556245 | A five-component 200-kDa MLL1 core complex containing human MLL1, WDR5, RbBP5, Ash2L, and DPY-30. | # |
|
SETD1A
(details) |
29010 | SET domain containing 1A | 9739 | O15047 | SET1A_HUMAN | RRM_1 PF00076 97-166, N-SET PF11764 1419-1559, SET PF00856 1580-1685 | Setd1a | 2446244 | # | # | KMT, RBM | Chromatin-modifying enzymes / K-methyltransferases, RNA binding motif (RRM) containing | Histone modification write | Histone methylation | 17355966 | COMPASS | histone | H3K4 | H3K4me | 17355966 | The CFP1 complex contains human homologues of the COMPASS complex, including Set1A=SETD1A, Wdr5, Ash2, Rbbp5, and Wdr82 (previously denoted hSwd2). The human Set1A-CFP1 complex exhibits histone H3-Lys4 methyltransferase activity in vitro. | # |
|
TLE2
(details) |
11838 | transducin-like enhancer of split 2 | 7089 | Q04725 | TLE2_HUMAN | TLE_N PF03920 18-130, WD40 PF00400 450-484 504-531 550-575 580-617 665-698 712-739 | Tle2 | 104635 | Q9WVB2 | TLE2_MOUSE | WDR | WD repeat domain containing | Histone modification cofactor | # | 17041588 | # | histone | H3 | H3K4, H3K9, H3K27me | 17041588 | CUL4-DDB1 complexes interact with multiple WD40-repeat proteins (WDRs) including TLE1-3, WDR5, L2DTL (also known as CDT2) and the Polycomb-group protein EED (also known as ESC). WDR5 and EED are core components of histone methylation complexes that are essential for histone H3 methylation and epigenetic control at K4 or K9 and K27, respectively. | # |
|
WDR5
(details) |
12757 | WD repeat domain 5 | 11091 | P61964 | WDR5_HUMAN | WD40 PF00400 38-72 78-115 119-157 161-199 203-242 246-287 292-331 | Wdr5 | 2155884 | P61965 | WDR5_MOUSE | WDR | WD repeat domain containing | Histone modification read | # | 16946699 | ATAC, NSL, RING2-L3MBTL2, COMPASS, Menin-associated_HMT, MLL-HCF, CHD8, MLL2/3, COMPASS-like MLL1,2, MLL4/WBP7, COMPASS-like MLL3,4 | histone | H3K4, H3K4me1, H3K4me2, H3K4me3 | # | 16946699 | The WD40 domain of WDR5 represents a new class of histone methyl-lysine recognition domains that is important for recruiting H3K4 methyltransferases to K4-dimethylated histone H3 tail as well as for global and gene-specific K4 trimethylation. Here is given the crystal structures of full-length WDR5, WDR5Delta23 and its complexes with unmodified, mono-, di- and trimethylated histone H3K4 peptides. | # |