| HGNC approved symbol | DPY30 |
| HGNC ID | HGNC:24590 |
| HGNC approved name | dpy-30 homolog (C. elegans) |
| Entrez gene ID | GeneID:84661
(SSTAR profile) |
| UniProt AC (human) | Q9C005 |
| UniProt ID (human) | DPY30_HUMAN |
| Pfam domains | Dpy-30 PF05186 (52-92) |
| MGI symbol | Dpy30 |
| MGI ID | MGI:1913560 |
| UniProt AC (mouse) | Q99LT0 |
| UniProt ID (mouse) | DPY30_MOUSE |
| HGNC gene family tag | # |
| HGNC gene family description | # |
| Function | Histone modification write cofactor |
| Modification | Histone methylation |
| PMID for information on function | PMID:19556245 |
| Protein complex | COMPASS, Menin-associated_HMT, MLL-HCF, CHD8, MLL2/3, COMPASS-like MLL1,2, MLL4/WBP7, COMPASS-like MLL3,4 |
| Target molecule | histone |
| Target entity | # |
| Product | # |
| PMID for information on target | PMID:19556245 |
| Comment | The isolated MLL1 SET domain is an H3K4 monomethyltransferase. When the MLL1 SET domain fragment is assembled with a complex containing WDR5, RbBP5, Ash2L, and DPY-30, the rate of lysine methylation is dramatically increased, but only to the dimethyl form of H3K4, suggesting that the MLL1 core complex is predominantly a dimethyltransferase. |
| Status of entry | # |