| HGNC approved symbol | TLE2 |
| HGNC ID | HGNC:11838 |
| HGNC approved name | transducin-like enhancer of split 2 |
| Entrez gene ID | GeneID:7089 (SSTAR profile) |
| UniProt AC (human) | Q04725 |
| UniProt ID (human) | TLE2_HUMAN |
| Pfam domains | TLE_N PF03920 (18-130) WD40 PF00400 (450-484, 504-531, 550-575, 580-617, 665-698, 712-739) |
| MGI symbol | Tle2 |
| MGI ID | MGI:104635 |
| UniProt AC (mouse) | Q9WVB2 |
| UniProt ID (mouse) | TLE2_MOUSE |
| HGNC gene family tag | WDR |
| HGNC gene family description | WD repeat domain containing |
| Function | Histone modification cofactor |
| Modification | # |
| PMID for information on function | PMID:17041588 |
| Protein complex | # |
| Target molecule | histone |
| Target entity | H3 |
| Product | H3K4, H3K9, H3K27me |
| PMID for information on target | PMID:17041588 |
| Comment | CUL4-DDB1 complexes interact with multiple WD40-repeat proteins (WDRs) including TLE1-3, WDR5, L2DTL (also known as CDT2) and the Polycomb-group protein EED (also known as ESC). WDR5 and EED are core components of histone methylation complexes that are essential for histone H3 methylation and epigenetic control at K4 or K9 and K27, respectively. |
| Status of entry | # |
| Expression range: | 0.0 to 288.94 |
| Mean expression: | 10.47 ± 23.45 |
| Median expression: | 2.41 |