| HGNC approved symbol | WDR5 |
| HGNC ID | HGNC:12757 |
| HGNC approved name | WD repeat domain 5 |
| Entrez gene ID | GeneID:11091
(SSTAR profile) |
| UniProt AC (human) | P61964 |
| UniProt ID (human) | WDR5_HUMAN |
| Pfam domains | WD40 PF00400 (38-72, 78-115, 119-157, 161-199, 203-242, 246-287, 292-331) |
| MGI symbol | Wdr5 |
| MGI ID | MGI:2155884 |
| UniProt AC (mouse) | P61965 |
| UniProt ID (mouse) | WDR5_MOUSE |
| HGNC gene family tag | WDR |
| HGNC gene family description | WD repeat domain containing |
| Function | Histone modification read |
| Modification | # |
| PMID for information on function | PMID:16946699 |
| Protein complex | ATAC, NSL, RING2-L3MBTL2, COMPASS, Menin-associated_HMT, MLL-HCF, CHD8, MLL2/3, COMPASS-like MLL1,2, MLL4/WBP7, COMPASS-like MLL3,4 |
| Target molecule | histone |
| Target entity | H3K4, H3K4me1, H3K4me2, H3K4me3 |
| Product | # |
| PMID for information on target | PMID:16946699 |
| Comment | The WD40 domain of WDR5 represents a new class of histone methyl-lysine recognition domains that is important for recruiting H3K4 methyltransferases to K4-dimethylated histone H3 tail as well as for global and gene-specific K4 trimethylation. Here is given the crystal structures of full-length WDR5, WDR5Delta23 and its complexes with unmodified, mono-, di- and trimethylated histone H3K4 peptides. |
| Status of entry | # |