HGNC approved symbol HGNC ID HGNC approved name Entrez gene ID UniProt AC (human)
UniProt ID (human)
Pfam domains MGI symbol MGI ID UniProt AC (mouse)
UniProt ID (mouse)
HGNC gene family tag HGNC gene family description Function Modification PMID for information on function Protein complex Target molecule Target entity Product PMID for information on target Comment Status of entry
BRMS1L
(details) 		20512 breast cancer metastasis-suppressor 1-like 84312 Q5PSV4 BRM1L_HUMAN Sds3 PF08598 62-184 Brms1l 1196337 Q3U1T3 BRM1L_MOUSE # # Histone modification erase Histone deacetylation 15451426 mSin3A histone # # 15451426 p40-associated Sin3A/HDAC1 complex can deacetylate histone peptides in vitro. p40 can also repress transcription when tethered to the Gal-regulated promoter by the Gal-DNA binding domain. #
DZIP3
(details) 		30938 DAZ interacting zinc finger protein 3 9666 Q86Y13 DZIP3_HUMAN TTC3_DZIP3_dom PF19179 229-330, HEPN_DZIP3 PF18738 421-546, zf-RING_2 PF13639 1148-1188 Dzip3 1917433 Q7TPV2 DZIP3_MOUSE RNF, PPP1R RING-type (C3HC4) zinc fingers, Serine/threonine phosphatases / Protein phosphatase 1, regulatory subunits Histone modification write Histone ubiquitination 18206970 # histone, RNA H2AK119 H2AK119ub 18206970 The N-CoR/HDAC1/3 complex specifically recruits a previously-unidentified specific histone H2A ubiquitin ligase, 2A-HUB/hRUL138 = DZIP3, to a subset of regulated gene promoters. #
HDAC1
(details) 		4852 histone deacetylase 1 3065 Q13547 HDAC1_HUMAN Hist_deacetyl PF00850 28-318 Hdac1 108086 O09106 HDAC1_MOUSE # # Histone modification erase Histone acetylation 10220385 SWI/SNF_Brm, NuRD, BHC, MeCP1, mSin3A, core HDAC, mSin3A-like complex, RING2-L3MBTL2, CREST-BRG1, LSD-CoREST histone H3, H4 # 10220385 HDAC1, HDAC4, HDAC5, and HDAC6 deacetylate all four core histones equally well, though deacetylation by HDAC4 and HDAC5 is incomplete. #
HDAC10
(details) 		18128 histone deacetylase 10 83933 Q969S8 HDA10_HUMAN Hist_deacetyl PF00850 24-321 Hdac10 2158340 Q6P3E7 HDA10_MOUSE # # Histone modification erase Histone acetylation 11861901 # histone H2AKac, H2BKac, H3Kac, H4Kac H2AK, H2BK, H3K, H4K 11861901 HDAC10 can deacetylate histones. #
HDAC11
(details) 		19086 histone deacetylase 11 79885 Q96DB2 HDA11_HUMAN Hist_deacetyl PF00850 35-318 Hdac11 2385252 Q91WA3 HDA11_MOUSE # # Histone modification erase Histone acetylation 9346952 # histone H2AKac, H2BKac, H3Kac, H4Kac H2AK, H2BK, H3K, H4K 9346952 HDAC11 is a bona fide histone deacetylase. #
HDAC2
(details) 		4853 histone deacetylase 2 3066 Q92769 HDAC2_HUMAN Hist_deacetyl PF00850 29-319 Hdac2 1097691 P70288 HDAC2_MOUSE # # Histone modification erase Histone acetylation 9346952 SWI/SNF_Brg1(I), SWI/SNF_Brg1(II), SWI/SNF_Brm, NuRD, BHC, MeCP1, mSin3A, core HDAC, mSin3A-like complex, RING2-L3MBTL2, LSD-CoREST histone H2AKac, H2BKac, H3Kac, H4Kac H2AK, H2BK, H3K, H4K 9346952 HDAC1, HDAC2, and HDAC3 constitute a human HDAC family. All three proteins possess histone deacetylase activity, and repress transcription when bound to a promoter. #
HDAC3
(details) 		4854 histone deacetylase 3 8841 O15379 HDAC3_HUMAN Hist_deacetyl PF00850 22-313 Hdac3 1343091 O88895 HDAC3_MOUSE # # Histone modification erase Histone acetylation 10655483 # histone H2AKac, H2BKac, H3Kac, H4Kac H2AK, H2BK, H3K, H4K 10655483 HDAC1, HDAC2, and HDAC3 constitute a human HDAC family. All three proteins possess histone deacetylase activity, and repress transcription when bound to a promoter. #
HDAC4
(details) 		14063 histone deacetylase 4 9759 P56524 HDAC4_HUMAN HDAC4_Gln PF12203 63-153, Hist_deacetyl PF00850 675-992 Hdac4 3036234 Q6NZM9 HDAC4_MOUSE # # Histone modification erase Histone acetylation 10220385 # histone H2AKac, H2BKac, H3Kac, H4Kac H2AK, H2BK, H3K, H4K 10220385 HDAC1, HDAC4, HDAC5, and HDAC6 deacetylate all four core histones equally well, though deacetylation by HDAC4 and HDAC5 is incomplete. #
HDAC5
(details) 		14068 histone deacetylase 5 10014 Q9UQL6 HDAC5_HUMAN HDAC4_Gln PF12203 67-162, Hist_deacetyl PF00850 704-1022 Hdac5 1333784 Q9Z2V6 HDAC5_MOUSE # # Histone modification erase Histone acetylation 10220385 # histone H2AKac, H2BKac, H3Kac, H4Kac H2AK, H2BK, H3K, H4K 10220385 HDAC1, HDAC4, HDAC5, and HDAC6 deacetylate all four core histones equally well, though deacetylation by HDAC4 and HDAC5 is incomplete. #
HDAC6
(details) 		14064 histone deacetylase 6 10013 Q9UBN7 HDAC6_HUMAN Hist_deacetyl PF00850 106-402 499-798, zf-UBP PF02148 1132-1193 Hdac6 1333752 Q9Z2V5 HDAC6_MOUSE # # Histone modification erase Histone acetylation 10220385 # histone H2AKac, H2BKac, H3Kac, H4Kac H2AK, H2BK, H3K, H4K 10220385 HDAC1, HDAC4, HDAC5, and HDAC6 deacetylate all four core histones equally well, though deacetylation by HDAC4 and HDAC5 is incomplete. (HDAC6 is possibly not involved in epigenetic signalling, but it deacetylates microtubules and heat shock protein 90; PMID:22498752) #
IKZF3
(details) 		13178 IKAROS family zinc finger 3 (Aiolos) 22806 Q9UKT9 IKZF3_HUMAN zf-C2H2 PF00096 146-168 202-222 Ikzf3 1342542 O08900 IKZF3_MOUSE ZNF, IKZF Zinc fingers, C2H2-type, "IKAROS zinc fingers" TF # # # DNA DNA motif # # Associates with histone deacetylase complexes containing HDAC1, MTA2 and SIN3A. (UniProt) #
ING2
(details) 		6063 inhibitor of growth family, member 2 3622 Q9H160 ING2_HUMAN ING PF12998 27-122 Ing2 1916510 Q9ESK4 ING2_MOUSE PHF Zinc fingers, PHD-type Histone modification read # 16728974 mSin3A-like complex histone H3K4me3 # 16728974 ING2, a native subunit of a repressive mSin3a-HDAC1 histone deacetylase complex, binds with high affinity to the trimethylated species. In response to DNA damage, recognition of H3K4me3 by the ING2 PHD domain stabilizes the mSin3a-HDAC1 complex at the promoters of proliferation genes. #
MBD3
(details) 		6918 methyl-CpG binding domain protein 3 53615 O95983 MBD3_HUMAN MBD PF01429 2-69, MBDa PF16564 79-149, MBD_C PF14048 152-241 Mbd3 1333812 Q9Z2D8 MBD3_MOUSE # # Histone modification erase cofactor Histone acetylation 12124384 NuRD histone # # 12124384 MBD3 has been identified as a component of the NuRD/Mi2 complex that shows chromatin remodeling and histone deacetylase activities. MBD3 MBD is necessary and sufficient for binding to HDAC1 and MTA2, two components of the NuRD/Mi2 complex. It has been suggested that mCpG-binding-defective MBD3 has evolutionarily conserved its MBD because of the secondary role played by the MBD in protein-protein interactions. #
MECP2
(details) 		6990 methyl CpG binding protein 2 4204 P51608 MECP2_HUMAN MBD PF01429 97-159 Mecp2 99918 Q9Z2D6 MECP2_MOUSE # # Histone modification write cofactor, Histone modification write cofactor, TF Histone methylation, Histone acetylation, TF repressor 10773092 # DNA mCG, DNA motif # 10773092 Methyl-CpG-binding protein 2 (MeCP2) contains a transcriptional repression domain (TRD), which can act by recruitment of a large transcriptional co-repressor complex containing histone deacetylases HDAC1 and 2. #
PHF21A
(details) 		24156 PHD finger protein 21A 51317 Q96BD5 PF21A_HUMAN PHD PF00628 491-532 Phf21a 2384756 Q6ZPK0 PF21A_MOUSE PHF Zinc fingers, PHD-type Histone modification erase cofactor Histone methylation 16140033 BHC, LSD-CoREST histone # # 16140033 LSD1 is a recently identified human lysine (K)-specific histone demethylase. LSD1 is associated with HDAC1/2; CoREST, a SANT domain-containing corepressor; and BHC80=PHF21A, a PHD domain-containing protein, among others. #
RB1
(details) 		9884 retinoblastoma 1 5925 P06400 RB_HUMAN DUF3452 PF11934 110-229, RB_A PF01858 375-573, RB_B PF01857 647-765, Rb_C PF08934 768-925 Rb1 97874 P13405 RB_MOUSE ENDOLIG Endogenous ligands Chromatin remodeling, Histone modification write Histone ubiquitination 19149898 CREST-BRG1, L3MBTL1 histone # # 19149898 Hypophosphorylated pRb can repress gene transcription at least partly by remodeling chromatin structure through its interactions with proteins such as HDAC1, BRM and BRG1. #
REST
(details) 		9966 RE1-silencing transcription factor 5978 Q13127 REST_HUMAN zf-C2H2 PF00096 304-326 Rest 104897 Q8VIG1 REST_MOUSE # # Histone modification erase cofactor, TF Histone acetylation, TF activator, TF repressor 12399542 # DNA DNA motif # 12399542 REST/NRSF can mediate repression, in part, through the association of its NH2-terminal repression domain with the mSin3/histone deacethylase 1,2 (HDAC1,2) complex. #
SMYD4
(details) 		21067 SET and MYND domain containing 4 114826 Q8IYR2 SMYD4_HUMAN SET PF00856 244-574, zf-MYND PF01753 296-335 Smyd4 2442796 Q8BTK5 SMYD4_MOUSE ZMYND Zinc fingers, MYND-type Histone modification erase cofactor Histone acetylation 18714374 # # # # # SMYD4 interacts with HDAC1 and HDAC3. #
SNAI2
(details) 		11094 snail family zinc finger 2 6591 O43623 SNAI2_HUMAN zf-C2H2 PF00096 128-150 159-181 185-207 213-235 241-260 Snai2 1096393 P97469 SNAI2_MOUSE SNAI, ZNF Snail homologs, Zinc fingers, C2H2-type Histone modification erase cofactor # 15734731, 22986495 # histone # # # May recruit HDAC1. PHD12 interacts directly with Sin3A/HDAC, which in turn interacts with Snail2. #
SPEN
(details) 		17575 spen family transcriptional repressor 23013 Q96T58 MINT_HUMAN RRM_1 PF00076 8-67 337-407 439-508 519-583, MINT_MID PF20809 2012-3467, MINT_RID PF20810 2366-2584 3009-3469, MINT_RAM7 PF20808 2654-2749, SPOC PF07744 3506-3662 Spen 1891706 Q62504 MINT_MOUSE RBM RNA binding motif (RRM) containing Histone modification erase cofactor, TF Histone acetylation, TF activator, TF repressor 11331609 # histone # # 11331609 SHARP =SPEN recruits histone deacetylase activity. SHARP is a potent transcriptional repressor whose repression domain (RD) interacts directly with SMRT and at least five members of the NuRD complex including HDAC1 and HDAC2. #
TRIM27
(details) 		9975 tripartite motif containing 27 5987 P14373 TRI27_HUMAN zf-C3HC4_4 PF15227 16-56, zf-B_box PF00643 93-132, PRY PF13765 318-366, SPRY PF00622 370-482 Trim27 97904 Q62158 TRI27_MOUSE TRIM, RNF Tripartite motif containing / Tripartite motif containing, RING-type (C3HC4) zinc fingers Histone modification erase cofactor Histone acetylation 19351825 # # # # # The recruitment of HDAC1 to the TBP-2 promoter is mediated by a protein complex consisting of RET finger protein (RFP; also called TRIM27) and the trimeric transcription factor NF-Y. #
ZMYM2
(details) 		12989 zinc finger, MYM-type 2 7750 Q9UBW7 ZMYM2_HUMAN zf-FCS PF06467 328-364 371-412 422-457 465-504 534-571 637-674 681-716 725-762 766-803, DUF3504 PF12012 1190-1359 Zmym2 1923257 Q9CU65 ZMYM2_MOUSE ZMYM Zinc fingers, MYM type Histone modification erase cofactor, TF Histone acetylation 12493763 BHC, LSD-CoREST DNA DNA motif # 12493763 A family of HDAC1,2-associated complexes includes proteins with a putative role in DNA binding such as ZNF261/XFIM (=ZMYM3), ZNF198/FIM (=ZMYM2), and ZNF217. #
ZMYM3
(details) 		13054 zinc finger, MYM-type 3 9203 Q14202 ZMYM3_HUMAN zf-FCS PF06467 353-389 406-444 449-490 497-535 546-580 591-624 632-664 676-714 718-754, DUF3504 PF12012 1184-1354 Zmym3 1927231 Q9JLM4 ZMYM3_MOUSE ZMYM Zinc fingers, MYM type Histone modification erase cofactor Histone acetylation 12493763 BHC DNA # # 12493763 A family of HDAC1,2-associated complexes includes proteins with a putative role in DNA binding such as ZNF261/XFIM (=ZMYM3), ZNF198/FIM (=ZMYM2), and ZNF217. #
ZNF217
(details) 		13009 zinc finger protein 217 7764 O75362 ZN217_HUMAN zf-C2H2 PF00096 128-150 156-178 377-397 472-493 # # # # ZNF Zinc fingers, C2H2-type Histone modification erase cofactor, TF Histone acetylation, TF repressor 12493763 BHC, LSD-CoREST DNA # # 12493763 A family of HDAC1,2-associated complexes includes proteins with a putative role in DNA binding such as ZNF261/XFIM (=ZMYM3), ZNF198/FIM (=ZMYM2), and ZNF217. #