| HGNC approved symbol | MBD3 |
| HGNC ID | HGNC:6918 |
| HGNC approved name | methyl-CpG binding domain protein 3 |
| Entrez gene ID | GeneID:53615 (SSTAR profile) |
| UniProt AC (human) | O95983 |
| UniProt ID (human) | MBD3_HUMAN |
| Pfam domains | MBD PF01429 (2-69) MBDa PF16564 (79-149) MBD_C PF14048 (152-241) |
| MGI symbol | Mbd3 |
| MGI ID | MGI:1333812 |
| UniProt AC (mouse) | Q9Z2D8 |
| UniProt ID (mouse) | MBD3_MOUSE |
| HGNC gene family tag | # |
| HGNC gene family description | # |
| Function | Histone modification erase cofactor |
| Modification | Histone acetylation |
| PMID for information on function | PMID:12124384 |
| Protein complex | NuRD |
| Target molecule | histone |
| Target entity | # |
| Product | # |
| PMID for information on target | PMID:12124384 |
| Comment | MBD3 has been identified as a component of the NuRD/Mi2 complex that shows chromatin remodeling and histone deacetylase activities. MBD3 MBD is necessary and sufficient for binding to HDAC1 and MTA2, two components of the NuRD/Mi2 complex. It has been suggested that mCpG-binding-defective MBD3 has evolutionarily conserved its MBD because of the secondary role played by the MBD in protein-protein interactions. |
| Status of entry | # |
| Expression range: | 0.0 to 85.13 |
| Mean expression: | 15.58 ± 9.68 |
| Median expression: | 13.76 |