HGNC approved symbol HGNC ID HGNC approved name Entrez gene ID UniProt AC (human)
UniProt ID (human)
Pfam domains MGI symbol MGI ID UniProt AC (mouse)
UniProt ID (mouse)
HGNC gene family tag HGNC gene family description Function Modification PMID for information on function Protein complex Target molecule Target entity Product PMID for information on target Comment Status of entry
AIRE
(details) 		360 autoimmune regulator 326 O43918 AIRE_HUMAN HSR PF03172 5-102, SAND PF01342 200-239, PHD PF00628 299-340 Aire 1338803 Q9Z0E3 AIRE_MOUSE PHF Zinc fingers, PHD-type Histone modification read, TF # 18292755 # histone, DNA H3K4, H3K4me3, DNA motif # 18292755 AIRE selectively interacts with histone H3 through its first plant homeodomain (PHD) finger (AIRE–PHD1) and preferentially binds to non-methylated H3K4 (H3K4me0). Accordingly, in vivo AIRE binds to and activates promoters containing low levels of H3K4me3 in human embryonic kidney 293 cells. AIRE–PHD1 is an important member of a newly identified class of PHD fingers that specifically recognize H3K4me0, thus providing a new link between the status of histone modifications. #
APOBEC3H
(details) 		24100 apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3H 164668 Q6NTF7 ABC3H_HUMAN APOBEC3 PF18771 25-157 # # # # APOBEC Apolipoprotein B mRNA editing enzymes DNA modification, RNA modification DNA demethylation, mRNA editing 22001110 APOB_mRNA_editosome DNA, RNA ssDNA, mRNA, mC dhU 22001110 Fig. A2 in the reference (Targets are exogenous retroviruses ssDNA like HIV or transposable elements/ endogenous retroelements e.g. LINEs, SINEs and LTR). #
ARNTL
(details) 		701 aryl hydrocarbon receptor nuclear translocator-like 406 O00327 BMAL1_HUMAN HLH PF00010 74-126, PAS PF00989 149-254, PAS_11 PF14598 339-442 Arntl 1096381 Q9WTL8 BMAL1_MOUSE bHLH Basic helix-loop-helix proteins Histone modification write cofactor, TF TF activator 14645221, 24395244 # histone # # 14645221, 24395244 The coincidence of a rhythm in histone H3 and histone H4 acetylation on the proximal E-box of hPer1 with transcriptional activation of per1 and per2 is consistent with the heterodimeric complexes of CLOCK, NPAS2 and BMAL1 = ARNTL recruiting a histone acetyltransferase (HAT)-containing transcriptional co-activation complex to achieve maximal target gene activation; CLOCK:BMAL1 functions like pioneer transcription factors and regulates the DNA accessibility of other transcription factors. #
ATF2
(details) 		784 activating transcription factor 2 1386 P15336 ATF2_HUMAN bZIP_1 PF00170 354-411 Atf2 109349 P16951 ATF2_MOUSE bZIP Basic leucine zipper proteins Histone modification write, TF Histone acetylation, TF activator 10821277 # histone, DNA H2B, H4, DNA motif # 10821277 ATF-2 is a histone acetyltransferase (HAT), which specifically acetylates histones H2B and H4 in vitro, exhibits histone acetyltransferase (HAT) activity. #
ATF7IP
(details) 		20092 activating transcription factor 7 interacting protein 55729 Q6VMQ6 MCAF1_HUMAN ATF7IP_BD PF16788 570-783, fn3_4 PF16794 1160-1259 Atf7ip 1858965 Q7TT18 MCAF1_MOUSE # # Histone modification write cofactor Histone methylation 14536086 # histone # # 14536086 Promoter H3-K9 trimethylation is the cause of transcriptional repression and that mAM/hAM facilitates conversion of H3-K9 dimethyl to trimethyl by ESET/SETDB1. #
ATXN7
(details) 		10560 ataxin 7 6314 O15265 ATX7_HUMAN SCA7 PF08313 332-395 Atxn7 2179277 Q8R4I1 ATX7_MOUSE ATXN Ataxins Histone modification write cofactor Histone acetylation 16494529 SAGA histone # # 16494529 Ataxin-7 (ATXN7) is a subunit of the GCN5 histone acetyltransferase–containing coactivator complexes TFTC/STAGA. TFTC/STAGA complexes purified from SCA7 mice have normal TRRAP, GCN5, TAF12, and SPT3 levels and that their histone or nucleosomal acetylation activities are unaffected. #
ATXN7L3
(details) 		25416 ataxin 7-like 3 56970 Q14CW9 AT7L3_HUMAN Sgf11 PF08209 81-112, SCA7 PF08313 207-237 Atxn7l3 3036270 A2AWT3 AT7L3_MOUSE # # Histone modification erase cofactor Histone deubiquitination 18206972 SAGA histone # # 18206972 ATXN7L3, USP22, and ENY2 are the human orthologs of yeast Sgf11, Ubp8, and Sus1, respectively, and they are integral components of TFTC/STAGA complex. These three proteins together form a module of the TFTC/STAGA complex, which specifically removes the ubiquitin moiety from monoubiquitinated histones H2A and H2B. #
BARD1
(details) 		952 BRCA1 associated RING domain 1 580 Q99728 BARD1_HUMAN zf-RING_6 PF14835 42-107, Ank_2 PF12796 428-523, BRCT PF00533 569-643 Bard1 1328361 O70445 BARD1_MOUSE ANKRD Ankyrin repeat domain containing Histone modification write Histone ubiquitination 19916563 BRCC, BRCA1-A histone H2AX, H2A, H2B, H3, H4 H2AXub, H2Aub, H2Bub, H3ub, H4ub 19916563, 12485996 BARD1, like CstF-50, also interacts with RNA polymerase II. BARD1-mediated inhibition of polyadenylation may prevent inappropriate RNA processing during transcription, #
BAZ1B
(details) 		961 bromodomain adjacent to zinc finger domain, 1B 9031 Q9UIG0 BAZ1B_HUMAN WAC_Acf1_DNA_bd PF10537 22-121, WHIM1 PF15612 726-762, WSD PF15613 899-1026, PHD PF00628 1187-1231, Bromodomain PF00439 1348-1427 Baz1b 1353499 Q9Z277 BAZ1B_MOUSE PHF Zinc fingers, PHD-type Histone modification write Histone phosphorylation 19092802 B-WICH, WINAC histone H2AXT142, H3 H2AXY142ph 19092802 WSTF=BAZ1B phosphorylates Tyr 142 of H2A.X, and WSTF activity has an important role in regulating several events that are critical for the DNA damage response. #
BPTF
(details) 		3581 bromodomain PHD finger transcription factor 2186 Q12830 BPTF_HUMAN DDT PF02791 241-299, PHD PF00628 393-434 2870-2915, WSD PF15613 457-524, Bromodomain PF00439 2939-3018 Bptf 2444008 # # PHF Zinc fingers, PHD-type Chromatin remodeling # 18974875 NuRF chromatin # # 18974875 Chromatin remodeling protein Bptf (Bromodomain PHD-finger Transcription Factor), the largest subunit of NURF (Nucleosome Remodeling Factor) in a mammal. #
BRCA1
(details) 		1100 breast cancer 1, early onset 672 P38398 BRCA1_HUMAN zf-C3HC4 PF00097 24-64, BRCT_assoc PF12820 361-492, BRCT PF00533 1649-1724 1758-1845 Brca1 104537 P48754 BRCA1_MOUSE RNF, PPP1R RING-type (C3HC4) zinc fingers, Serine/threonine phosphatases / Protein phosphatase 1, regulatory subunits Histone modification write cofactor, TF Histone acetylation, Histone methylation, Histone ubiquitination, TF activator, TF repressor 20820192 BRCC, BRCA1-A DNA DNA motif # 20820192 BRCA1 acts as a transcription factor, which regulates expression of many genes involved in many biological processes. DNMT1, the methylation maintenance enzyme, is a transcriptional target of BRCA1. Impaired function of BRCA1 leads to global DNA hypomethylation, loss of genomic imprinting, and an open chromatin configuration in several types of tissues examined in a BRCA1 mutant mouse model at premaligant stages. BRCA1 deficiency is also associated with significantly increased expression levels of several protooncogenes. #
CDK7
(details) 		1778 cyclin-dependent kinase 7 1022 P50613 CDK7_HUMAN Pkinase PF00069 12-295 Cdk7 102956 Q03147 CDK7_MOUSE CDK, TFIIH Cyclin-dependent kinases, General transcription factor IIH complex subunits Histone modification write Histone phosphorylation 10722743 # histone H1 # 10722743 Cdk7, is able to phosphorylate histone H1, and the basal activity is increased 2-fold in the presence of recombinant human cyclin H (the activating partner of Cdk7). #
CTCF
(details) 		13723 CCCTC-binding factor (zinc finger protein) 10664 P49711 CTCF_HUMAN zf-C2H2 PF00096 266-288 294-316 322-345 351-373 379-401 437-460 555-575 Ctcf 109447 Q61164 CTCF_MOUSE ZNF Zinc fingers, C2H2-type Chromatin remodeling, TF TF activator 16949368 # DNA DNA motif # 16949368 A CTCF-CHD8 complex is involved in both enhancer blocking and epigenetic remodeling at chromatin boundary in vivo. #
CXXC1
(details) 		24343 CXXC finger protein 1 30827 Q9P0U4 CXXC1_HUMAN PHD PF00628 29-73, zf-CXXC PF02008 163-208, CpG_bind_C PF12269 400-636 Cxxc1 1921572 Q9CWW7 CXXC1_MOUSE PHF Zinc fingers, PHD-type Chromatin remodeling, TF # 21407193 COMPASS DNA CG, DNA motif # 21407193 CFP1=CXXC1 is a CXXC domain-containing protein. CXXC domain proteins direct different chromatin-modifying activities to various chromatin regions. #
E2F6
(details) 		3120 E2F transcription factor 6 1876 O75461 E2F6_HUMAN E2F_TDP PF02319 65-128, E2F_CC-MB PF16421 143-237 E2f6 1354159 O54917 E2F6_MOUSE # # TF TF repressor # RING2-L3MBTL2, CHD8, MLL2/3, MLL4/WBP7 DNA DNA motif # # Epigenetic complex (MLL) partner. #
ENY2
(details) 		24449 enhancer of yellow 2 homolog (Drosophila) 56943 Q9NPA8 ENY2_HUMAN EnY2 PF10163 13-95 Eny2 1919286 Q9JIX0 ENY2_MOUSE # # Histone modification erase cofactor Histone ubiquitination 18206972 SAGA histone # # 18206972 ATXN7L3, USP22, and ENY2 are required as cofactors for the full transcriptional activity by nuclear receptors. Thus, the deubiquitinase activity of the TFTC/STAGA HAT complex is necessary to counteract heterochromatin silencing and acts as a positive cofactor for activation by nuclear receptors in vivo. #
FAM175A
(details) 		25829 family with sequence similarity 175, member A 84142 Q6UWZ7 F175A_HUMAN MPN_2A_DUB_like PF21125 9-172 Fam175a 1917931 Q8BPZ8 F175A_MOUSE # # Scaffold protein # 19261749 BRCA1-A TF # # 19261749 Abra1=FAM175A protein, which appears to act as a scaffold for the A complex. Abra1 is known to mediate the interaction of Rap80 with BRCA1. #
FOXA1
(details) 		5021 forkhead box A1 3169 P55317 FOXA1_HUMAN Forkhead_N PF08430 16-169, Forkhead PF00250 170-255, HNF_C PF09354 396-455 Foxa1 1347472 P35582 FOXA1_MOUSE FOX Forkhead boxes Chromatin remodeling, TF # 22406422 # chromatin, DNA DNA motif # # FOXA1 functions in organizing nucleosome positioning. #
FOXO1
(details) 		3819 forkhead box O1 2308 Q12778 FOXO1_HUMAN Forkhead PF00250 160-244, FOXO_KIX_bdg PF16675 430-506, FOXO-TAD PF16676 597-635 Foxo1 1890077 Q9R1E0 FOXO1_MOUSE FOX Forkhead boxes TF # 22406422 # histone, DNA DNA motif, H3, H4 # # FOXO1 interacts with core histones H3 and H4. #
FOXP1
(details) 		3823 forkhead box P1 27086 Q9H334 FOXP1_HUMAN FOXP-CC PF16159 302-370, Forkhead PF00250 465-541 Foxp1 1914004 P58462 FOXP1_MOUSE FOX Forkhead boxes TF # 22406422 # histone, DNA DNA motif # # Recruitment of specific chromatin-modifying complexes with HDAC activity. #
FOXP2
(details) 		13875 forkhead box P2 93986 O15409 FOXP2_HUMAN FOXP-CC PF16159 342-410, Forkhead PF00250 504-581 Foxp2 2148705 P58463 FOXP2_MOUSE FOX Forkhead boxes TF # 22406422 # histone, DNA DNA motif # # Recruitment of specific chromatin-modifying complexes with HDAC activity. #
FOXP3
(details) 		6106 forkhead box P3 50943 Q9BZS1 FOXP3_HUMAN FOXP-CC PF16159 193-263, Forkhead PF00250 337-414 Foxp3 1891436 Q99JB6 FOXP3_MOUSE FOX Forkhead boxes TF # 22406422 # histone, DNA DNA motif # # Recruitment of specific chromatin-modifying complexes with HDAC activity. #
FOXP4
(details) 		20842 forkhead box P4 116113 Q8IVH2 FOXP4_HUMAN FOXP-CC PF16159 305-371, Forkhead PF00250 467-544 Foxp4 1921373 Q9DBY0 FOXP4_MOUSE FOX Forkhead boxes TF # 22406422 # histone, DNA DNA motif # # Recruitment of specific chromatin-modifying complexes with HDAC activity. #
GSG2
(details) 		19682 germ cell associated 2 (haspin) 83903 Q8TF76 HASP_HUMAN Haspin_kinase PF12330 420-783 Gsg2 1194498 Q9Z0R0 HASP_MOUSE # # Histone modification write Histone phosphorylation 20705812 # histone H3T3 H3T3ph 20705812 Phosphorylation of histone H3 threonine 3 (H3T3ph) by Haspin=GSG2 is necessary for CPC accumulation at centromeres and that CPC subunit Survivin binds directly to H3T3ph. #
GTF2I
(details) 		4659 general transcription factor IIi 2969 P78347 GTF2I_HUMAN GTF2I PF02946 112-188 360-436 465-541 569-647 733-809 868-942 Gtf2i 1202722 Q9ESZ8 GTF2I_MOUSE # # TF # 9334314 BHC DNA DNA motif # # Added because it is a complex partner. #
GTF3C4
(details) 		4667 general transcription factor IIIC, polypeptide 4, 90kDa 9329 Q9UKN8 TF3C4_HUMAN TFIIIC_delta PF12657 61-517, DUF5921 PF19336 516-592, zf-TFIIIC PF12660 741-789 Gtf3c4 2138937 Q8BMQ2 TF3C4_MOUSE KAT, GTF Chromatin-modifying enzymes / K-acetyltransferases, General transcription factors Histone modification write Histone acetylation 10523658 # histone H3 # 10523658 hTFIIIC90=GTF3C4 has an intrinsic histone acetyltransferase activity with a substrate specificity for histone H3. #
HDGF
(details) 		4856 hepatoma-derived growth factor 3068 P51858 HDGF_HUMAN PWWP PF00855 13-93 Hdgf 1194494 P51859 HDGF_MOUSE # # Chromatin remodeling, TF TF repressor 18331345, 17974029 # DNA DNA motif # 18331345 SUMOylated HDGF is not bound to chromatin. #
HINFP
(details) 		17850 histone H4 transcription factor 25988 Q9BQA5 HINFP_HUMAN zf-C2H2_4 PF13894 229-251, zf-C2H2 PF00096 255-278 345-368 Hinfp 2429620 Q8K1K9 HINFP_MOUSE ZNF Zinc fingers, C2H2-type Histone modification read, TF TF activator, TF repressor 14585971 # histone, DNA H4, DNA motif # 14585971 HiNF-P interacts with conserved H4 cell cycle regulatory sequences in vivo. #
HLTF
(details) 		11099 helicase-like transcription factor 6596 Q14527 HLTF_HUMAN HIRAN PF08797 61-154, SNF2-rel_dom PF00176 242-720, zf-C3HC4_2 PF13923 760-800, Helicase_C PF00271 834-950 Hltf 1196437 Q6PCN7 HLTF_MOUSE RNF RING-type (C3HC4) zinc fingers Chromatin remodeling cofactor # 18719106 # chromatin # # 18719106 Acts as a ubiquitin ligase for 'Lys-63'-linked polyubiquitination of chromatin-bound PCNA. #
IKZF1
(details) 		13176 IKAROS family zinc finger 1 (Ikaros) 10320 Q13422 IKZF1_HUMAN zf-C2H2 PF00096 145-167 173-195 201-224 Ikzf1 1342540 Q03267 IKZF1_MOUSE ZNF, IKZF Zinc fingers, C2H2-type, IKAROS zinc fingers Chromatin remodeling, TF # 19141594 # DNA DNA motif # 19141594 Ikaros=IKZF1 forms dimers and multimers efficiently, and it has been proposed that Ikaros induces heterochromatization or chromatin remodeling of mouse DNA, resulting in repression or activation of target genes. The results provide insight into possible structural and functional roles of pericentromeric regions in mouse and human chromosomes. #
IKZF3
(details) 		13178 IKAROS family zinc finger 3 (Aiolos) 22806 Q9UKT9 IKZF3_HUMAN zf-C2H2 PF00096 146-168 202-222 Ikzf3 1342542 O08900 IKZF3_MOUSE ZNF, IKZF Zinc fingers, C2H2-type, "IKAROS zinc fingers" TF # # # DNA DNA motif # # Associates with histone deacetylase complexes containing HDAC1, MTA2 and SIN3A. (UniProt) #
KAT2A
(details) 		4201 K(lysine) acetyltransferase 2A 2648 Q92830 KAT2A_HUMAN PCAF_N PF06466 92-335, Acetyltransf_1 PF00583 536-627, Bromodomain PF00439 738-819 Kat2a 1343101 Q9JHD2 KAT2A_MOUSE KAT Chromatin-modifying enzymes / K-acetyltransferases Histone modification write Histone acetylation 10611234 TFTC-HAT, SAGA, ATAC, STAGA histone # # 10611234 Current models of HAT protein activity suggest that one hypothesis for the role of hGCN5=KAT2A in c-Myc's activities might be due to the relaxing of chromatin packaging at target genes following histone acetylation by hGCN5. #
KLF18
(details) 		51793 Kruppel like factor 18 105378952 A0A0U1RQI7 KLF18_HUMAN zf-C2H2 PF00096 994-1018 1024-1046 Zfp352 2387418 A2AML7 A2AML7_MOUSE KLF Kruppel like factors TF # 24244731 # DNA DNA # 24244731 # New
MAX
(details) 		6913 MYC associated factor X 4149 P61244 MAX_HUMAN HLH PF00010 24-74 Max 96921 P28574 MAX_MOUSE bHLH Basic helix-loop-helix proteins Histone modification write cofactor, TF Histone methylation, Histone acetylation, TF activator, TF repressor 18271930, 12004135 CHD8, MLL2/3, MLL4/WBP7 DNA DNA motif # 18271930, 12004135 Part of a multimeric protein complex that contains E2F6, Mga and Max. The complex contains chromatin modifiers such as a novel histone methyltransferase that modifies lysine 9 of histone H3, HP1gamma, and Polycomb group (PcG) proteins. #
MBD1
(details) 		6916 methyl-CpG binding domain protein 1 4152 Q9UIS9 MBD1_HUMAN MBD PF01429 2-70, zf-CXXC PF02008 169-215 219-262 331-377 Mbd1 1333811 Q9Z2E2 MBD1_MOUSE # # Histone modification write cofactor, TF Histone methylation, TF repressor 15327775 # DNA mCG, DNA motif # 15327775 MBD1 recruits SETDB1 to the large subunit of chromatin assembly factor CAF-1 to form an S phase-specific CAF-1/MBD1/SETDB1 complex that facilitates methylation of H3-K9 during replication-coupled chromatin assembly. In the absence of MBD1, H3-K9 methylation is lost at multiple genomic loci and results in activation of p53BP2 gene, normally repressed by MBD1 in HeLa cells. Data suggest a model in which H3-K9 methylation by SETDB1 is dependent on MBD1 and is heritably maintained through DNA replication to support the formation of stable heterochromatin at methylated DNA. #
MBD2
(details) 		6917 methyl-CpG binding domain protein 2 8932 Q9UBB5 MBD2_HUMAN MBD PF01429 150-213, MBDa PF16564 221-294, MBD_C PF14048 296-385 Mbd2 1333813 Q9Z2E1 MBD2_MOUSE # # Histone modification write cofactor, Histone modification erase cofactor, TF Histone methylation, Histone acetylation, TF repressor 16415179 NuRD, MeCP1 DNA mCG, DNA motif # 16415179 Wild-type subnuclear distribution of p66alpha and p66beta depends on the presence of MBD2. Both proteins interact with the tails of all octamer histones in vitro, and acetylation of histone tails interferes with p66 binding. #
MBIP
(details) 		20427 MAP3K12 binding inhibitory protein 1 51562 Q9NS73 MBIP1_HUMAN Mbip 1918320 Q99LQ1 MBIP1_MOUSE # # Histone modification write cofactor Histone acetylation 19103755 ATAC histone # # 19103755 Novel proteins identified as STAGA/ TFTC subunits, such as ATAC2, DR1, MBIP, WDR5, YEATS2, and ZZZ3/ATAC1. #
MECP2
(details) 		6990 methyl CpG binding protein 2 4204 P51608 MECP2_HUMAN MBD PF01429 97-159 Mecp2 99918 Q9Z2D6 MECP2_MOUSE # # Histone modification write cofactor, Histone modification write cofactor, TF Histone methylation, Histone acetylation, TF repressor 10773092 # DNA mCG, DNA motif # 10773092 Methyl-CpG-binding protein 2 (MeCP2) contains a transcriptional repression domain (TRD), which can act by recruitment of a large transcriptional co-repressor complex containing histone deacetylases HDAC1 and 2. #
MGA
(details) 		14010 MGA, MAX dimerization protein 23269 Q8IWI9 MGAP_HUMAN T-box PF00907 77-259, MGA_dom PF16059 1043-1085, HLH PF00010 2425-2474 Mga 1352483 A2AWL7 MGAP_MOUSE # # Histone modification write cofactor, TF Histone methylation, Histone acetylation, TF activator, TF repressor # RING2-L3MBTL2, CHD8, MLL2/3, MLL4/WBP7 DNA DNA motif # # Added because it is a complex partner #
MTF2
(details) 		29535 metal response element binding transcription factor 2 22823 Q9Y483 MTF2_HUMAN Tudor_2 PF18104 49-84, PHD PF00628 105-154, Mtf2_C PF14061 544-590 Mtf2 105050 Q02395 MTF2_MOUSE TDRD, PHF Tudor domain containing, "Zinc fingers, PHD-type" Polycomb group (PcG) protein # 21881606 PRC2 histone H3K36me3 # 21881606 Polycomb group (PcG) that binds histone H3 trimethylated at Lys-36. #
MYBBP1A
(details) 		7546 MYB binding protein (P160) 1a 10514 Q9BQG0 MBB1A_HUMAN DNA_pol_phi PF04931 38-834 Mybbp1a 106181 Q7TPV4 MBB1A_MOUSE # # Chromatin remodeling cofactor # 16603771 B-WICH chromatin # # 16603771 The WSTF (Williams syndrome transcription factor) protein is involved in vitamin D-mediated transcription and replication as a component of two distinct ATP-dependent chromatin remodeling complexes, WINAC and WICH, respectively. The WICH complex (WSTF-SNF2h) interacts with several nuclear proteins as follows: Sf3b155/SAP155, RNA helicase II/Guα, Myb-binding protein 1a, CSB. #
MYO1C
(details) 		7597 myosin IC 4641 O00159 MYO1C_HUMAN Myosin_head PF00063 49-718, IQ PF00612 737-755 758-778, Myosin_TH1 PF06017 887-1058 Myo1c 106612 Q9WTI7 MYO1C_MOUSE MYOI Myosins / Myosin superfamily : Class I Chromatin remodeling cofactor # 16603771 B-WICH chromatin # # 16603771 The WSTF (Williams syndrome transcription factor) protein is involved in vitamin D-mediated transcription and replication as a component of two distinct ATP-dependent chromatin remodeling complexes, WINAC and WICH, respectively. The WICH complex (WSTF-SNF2h) interacts with several nuclear proteins as follows: Sf3b155/SAP155, RNA helicase II/Gualpha, Myb-binding protein 1a, CSB, the proto-oncogene Dek, and nuclear myosin 1 in a large 3-MDa assembly, B-WICH, during active transcription. #
NAA60
(details) 		25875 N(alpha)-acetyltransferase 60, NatF catalytic subunit 79903 Q9H7X0 NAA60_HUMAN Acetyltransf_1 PF00583 27-155 Naa60 1922013 Q9DBU2 NAA60_MOUSE NAA N(alpha)-acetyltransferase subunits Histone modification write Histone acetylation 21981917 # histone H4K20, H4K79, H4K91 H4K20ac, H4K79ac, H4K91ac 21981917 HAT4 =NAA60 is localized in the Golgi apparatus and displays a substrate preference for lysine residues of free histone H4, including H4K79 and H4K91, that reside in the globular domain of H4. #
NFRKB
(details) 		7802 nuclear factor related to kappaB binding protein 4798 Q6P4R8 NFRKB_HUMAN NFRKB_winged PF14465 375-480 Nfrkb 2442410 Q6PIJ4 NFRKB_MOUSE INO80 INO80 complex subunits Chromatin remodeling cofactor, TF # 16230350 Ino80 DNA DNA motif # 16230350 Five proteins appear to be unique to the human INO80 complex. NFRKB is a large (more than 1300 amino acids) protein. The C-terminal half of NFRKB contains low complexity, mucin-like repeats. #
NFYB
(details) 		7805 nuclear transcription factor Y, beta 4801 P25208 NFYB_HUMAN CBFD_NFYB_HMF PF00808 58-122 Nfyb 97317 P63139 NFYB_MOUSE # # Chromatin remodeling, TF TF activator 15243141, 23332751 # DNA DNA motif # 23332751 NF-Y is a sequence-specific transcription factor with nucleosome-like properties of nonspecific DNA binding and helps establish permissive chromatin modifications at CCAAT promoters. #
NOC2L
(details) 		24517 nucleolar complex associated 2 homolog (S. cerevisiae) 26155 Q9Y3T9 NOC2L_HUMAN Noc2 PF03715 331-624 Noc2l 1931051 Q9WV70 NOC2L_MOUSE # # Chromatin remodeling, TF TF repressor 15100215 # histone H3 # 15100215 INHAT =NOC2L (inhibitor of acetyltransferases) is a specific histone H3 N-terminal tail-binding complex. #
NPAS2
(details) 		7895 neuronal PAS domain protein 2 4862 Q99743 NPAS2_HUMAN HLH PF00010 11-58, PAS PF00989 84-151, PAS_11 PF14598 250-353 Npas2 109232 P97460 NPAS2_MOUSE bHLH Basic helix-loop-helix proteins Chromatin remodeling, TF TF activator 14645221, 24196956 # DNA DNA motif # 14645221 There is a time-dependent recruitment of chromatin remodeling machinery by NPAS2 in vivo. #
PHF1
(details) 		8919 PHD finger protein 1 5252 O43189 PHF1_HUMAN Tudor_2 PF18104 34-69, PHD PF00628 90-139, Mtf2_C PF14061 534-564 Phf1 98647 Q9Z1B8 PHF1_MOUSE TDRD, PHF Tudor domain containing, Zinc fingers, PHD-type Polycomb group (PcG) protein # 18086877 PRC2 # # # 18086877 The EED-EZH2 complex, containing the core subunits EZH2, EED, SUZ12, and RbAp48, functions as a histone H3K27-specific methyltransferase. The related EED-EZH2 protein complex is distinguished from the previous complex by the presence of another PcG protein, hPHF1. #
PHF19
(details) 		24566 PHD finger protein 19 26147 Q5T6S3 PHF19_HUMAN Tudor_2 PF18104 43-78, PHD PF00628 99-148, Mtf2_C PF14061 531-578 Phf19 1921266 Q9CXG9 PHF19_MOUSE TDRD, PHF Tudor domain containing, Zinc fingers, PHD-type Chromatin remodeling, Histone modification write cofactor Histone acetylation 15563832 PRC2 histone # # 15563832 Based on motifs identified within the hPCL3 =PHF19 open reading frames, hPCL3 proteins are likely to be nuclear proteins that regulate transcription and/or chromatin structure. #
PRDM16
(details) 		14000 PR domain containing 16 63976 Q9HAZ2 PRD16_HUMAN PRDM2_PR PF21549 84-212, zf-C2H2_6 PF13912 230-250, zf-C2H2 PF00096 281-303 309-331 337-360 366-388 394-416 424-443 951-973 979-1002 1008-1030 Prdm16 1917923 A2A935 PRD16_MOUSE ZNF Zinc fingers, C2H2-type Histone modification write cofactor, TF Histone methylation, TF repressor 12816872, 23856557 # histone, DNA H3K9, DNA motif H3K9me 23856557 The Prdm family may possess HKMTase properties. Some Prdms show intrinsic HKMTase activity (Prdm2, Prdm3, Prdm8, Prdm9, and Prdm16). In addition, Prdm1, Prdm5, and Prdm6 lack intrinsic HKMTase activity, but instead recruit G9a/Ehmt2/KMT1C, a strong mammalian histone H3 lysine 9 (H3K9) methyltransferase, to mediate HKMTase activity (see Fog et al., 2012 for a review). Another structural feature is that the Prdm family has multiple kruppel-type zinc finger (ZF) domains in the C-terminus involved in sequence-specific DNA binding and protein-protein interactions. #
RARA
(details) 		9864 retinoic acid receptor, alpha 5914 P10276 RARA_HUMAN zf-C4 PF00105 87-155, Hormone_recep PF00104 227-399 Rara 97856 P11416 RARA_MOUSE NR Nuclear hormone receptors Histone modification write cofactor, TF Histone methylation, TF activator, TF repressor 19377461 # histone H3K4 H3K4me, H3K4me2 19377461 MLL5 is biochemically identified in a GlcNAcylation-dependent multi-subunit complex associating with nuclear retinoic acid receptor RARalpha (also known as RARA), serving as a mono- and di-methyl transferase to H3K4. #
REST
(details) 		9966 RE1-silencing transcription factor 5978 Q13127 REST_HUMAN zf-C2H2 PF00096 304-326 Rest 104897 Q8VIG1 REST_MOUSE # # Histone modification erase cofactor, TF Histone acetylation, TF activator, TF repressor 12399542 # DNA DNA motif # 12399542 REST/NRSF can mediate repression, in part, through the association of its NH2-terminal repression domain with the mSin3/histone deacethylase 1,2 (HDAC1,2) complex. #
RUVBL1
(details) 		10474 RuvB-like AAA ATPase 1 8607 Q9Y265 RUVB1_HUMAN TIP49 PF06068 14-368, TIP49_C PF17856 374-439 Ruvbl1 1928760 P60122 RUVB1_MOUSE INO80, AATP INO80 complex subunits, ATPases / AAA-type Chromatin remodeling, Histone modification write Histone phosphorylation 14695187 Ino80, SWR, NuA4, NuA4-related complex, CHD8, MLL2/3, MLL4/WBP7, SRCAP chromatin # # 14695187 The ability of TIP49=RUVBL1 to inhibit ITF-2 gene expression has been linked to decreased acetylation of histones in the vicinity of the TCF-binding sites in the ITF-2 promoter region. It has been suggested that TIP49 is an important cofactor in beta-catenin/TCF gene regulation in normal and neoplastic cells, likely functioning in chromatin remodeling. #
SFMBT2
(details) 		20256 Scm-like with four mbt domains 2 57713 Q5VUG0 SMBT2_HUMAN MBT PF02820 78-146 191-258 301-375 411-478, SLED PF12140 529-642, SAM_1 PF00536 823-885 Sfmbt2 2447794 Q5DTW2 SMBT2_MOUSE SAMD Sterile alpha motif (SAM) domain containing Histone modification read, Polycomb group (PcG) protein, TF TF repressor 23385818 # histone, DNA H3K9me2, H3K9me3, H3K27me3, H4K20me2, H4K20me3 H3, H4 23385818 SFMBT2 binds preferentially to methylated histone H3 and H4 that are associated with transcriptional repression. Occupancy of SFMBT2 coincide with enrichment of diand tri-methylated H3K9 and H4K20 as well as tri-methylated H3K27 at the HOXB13 gene promoter. #
SFPQ
(details) 		10774 splicing factor proline/glutamine-rich 6421 P23246 SFPQ_HUMAN RRM_1 PF00076 299-363 374-432, NOPS PF08075 444-496 Sfpq 1918764 Q8VIJ6 SFPQ_MOUSE RBM RNA binding motif (RRM) containing Chromatin remodeling cofactor, RNA modification, TF TF repressor 22783022, 10858305, 8449401 # DNA, RNA # # 22783022, 10858305, 8449401 Four components of the Sin3a transcriptional repressor complex: SAP130, SUDS3, SFPQ, and TGIF2. Since the RNA splicing factors do not have an endogenous DNA relaxation activity, topoisomerase I (Chromatin remodeller) gets stimulated by the interaction with the PSF= SFPQ/p54nrb heterodimer. PSF=SFPQ is an essential pre-mRNA splicing factor required early in spliceosome formation. #
SIN3A
(details) 		19353 SIN3 transcription regulator family member A 25942 Q96ST3 SIN3A_HUMAN PAH PF02671 142-186 323-380 478-522, Sin3_corepress PF08295 551-647, Sin3a_C PF16879 885-1192 Sin3a 107157 Q60520 SIN3A_MOUSE # # Histone modification erase cofactor, TF Histone acetylation, TF activator, TF repressor 12670868 SWI/SNF_Brg1(I), SWI/SNF_Brm, mSin3A, mSin3A-like complex histone, DNA DNA motif # 12670868 Human Sin3 deacetylase and trithorax-related Set1/Ash2 histone H3-K4 methyltransferase are tethered together selectively by the cell-proliferation factor HCF-1. #
SIN3B
(details) 		19354 SIN3 transcription regulator family member B 23309 O75182 SIN3B_HUMAN PAH PF02671 60-104 182-235 322-366, Sin3_corepress PF08295 394-447 435-521, Sin3a_C PF16879 775-1081 Sin3b 107158 Q62141 SIN3B_MOUSE # # Histone modification erase cofactor, TF Histone acetylation, TF repressor 12670868 mSin3A histone, DNA DNA motif # 12670868 Human Sin3 deacetylase and trithorax-related Set1/Ash2 histone H3-K4 methyltransferase are tethered together selectively by the cell-proliferation factor HCF-1. #
SMARCA2
(details) 		11098 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2 6595 P51531 SMCA2_HUMAN QLQ PF08880 174-208, HSA PF07529 438-508, BRK PF07533 591-633, SNF2-rel_dom PF00176 727-1021, Helicase_C PF00271 1051-1164, SnAC PF14619 1259-1326, Bromodomain PF00439 1421-1489 Smarca2 99603 Q6DIC0 SMCA2_MOUSE # # Histone modification read, TF TF activator 22464331 BAF, nBAF, npBAF, WINAC, bBAF, SWI/SNF BRM-BRG1 histone, DNA H3, DNA motif # 22464331 Fig. 5 in the reference. #
SMARCA4
(details) 		11100 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4 6597 P51532 SMCA4_HUMAN QLQ PF08880 172-205, HSA PF07529 461-532, BRK PF07533 612-653, SNF2-rel_dom PF00176 754-1051, Helicase_C PF00271 1081-1194, SnAC PF14619 1321-1388, Bromodomain PF00439 1477-1547 Smarca4 88192 Q3TKT4 SMCA4_MOUSE # # Histone modification read, TF TF activator 17582821 BAF, nBAF, npBAF, PBAF, SWI/SNF_Brg1(I), SWI/SNF_Brg1(II), SWI/SNF_Brm, SWI/SNF-like_EPAFa, WINAC, SWI/SNF-like EPAFB, bBAF, SWI/SNF BRM-BRG1, CREST-BRG1 histone H3, H4 # 17582821 The BRG1 =SMARCA4 bromodomain exhibits binding, albeit weak, to acetylated peptides that are derived from histones H3 and H4. #
SP1
(details) 		11205 Sp1 transcription factor # P08047 SP1_HUMAN zf-C2H2 PF00096 656-680 686-708 Sp1 98372 O89090 SP1_MOUSE SP, ZNF Specificity protein transcription factors, Zinc fingers, C2H2-type Chromatin remodeling, TF TF activator, TF repressor 17827154, 18850004 CREST-BRG1 DNA DNA motif # 17049555 # #
SP140
(details) 		17133 SP140 nuclear body protein 11262 Q13342 SP140_HUMAN HSR PF03172 38-135, SAND PF01342 583-661, PHD PF00628 693-733, Bromodomain PF00439 779-833 Sp140 3702467 # # PHF Zinc fingers, PHD-type Histone modification read, TF # 22464331 # histone H3 # 22464331 Fig. 5 in the reference. #
SPEN
(details) 		17575 spen family transcriptional repressor 23013 Q96T58 MINT_HUMAN RRM_1 PF00076 8-67 337-407 439-508 519-583, MINT_MID PF20809 2012-3467, MINT_RID PF20810 2366-2584 3009-3469, MINT_RAM7 PF20808 2654-2749, SPOC PF07744 3506-3662 Spen 1891706 Q62504 MINT_MOUSE RBM RNA binding motif (RRM) containing Histone modification erase cofactor, TF Histone acetylation, TF activator, TF repressor 11331609 # histone # # 11331609 SHARP =SPEN recruits histone deacetylase activity. SHARP is a potent transcriptional repressor whose repression domain (RD) interacts directly with SMRT and at least five members of the NuRD complex including HDAC1 and HDAC2. #
SUPT3H
(details) 		11466 suppressor of Ty 3 homolog (S. cerevisiae) 8464 O75486 SUPT3_HUMAN TFIID-18kDa PF02269 26-115 # # # # # # Histone modification write cofactor Histone acetylation 11564863 PCAF, SAGA, STAGA histone # # 11564863 GCN5 is a histone acetyltransferase (HAT) originally identified in Saccharomyces cerevisiae and required for transcription of specific genes within chromatin as part of the SAGA (SPT-ADA-GCN5 acetylase) coactivator complex. Mammalian cells have two distinct GCN5 homologs (PCAF and GCN5L) that have been found in three different SAGA-like complexes (PCAF complex, TFTC [TATA-binding-protein-free TAFII-containing complex], and STAGA [SPT3-TAFII31-GCN5L acetylase]). #
SUPT7L
(details) 		30632 suppressor of Ty 7 (S. cerevisiae)-like 9913 O94864 ST65G_HUMAN Bromo_TP PF07524 151-228 Supt7l 1919445 Q9CZV5 ST65G_MOUSE # # Histone chaperone # 11564863 TFTC-HAT, STAGA histone # # 11564863 STAGA contains homologs of most yeast SAGA components, including two novel human proteins with histone-like folds and sequence relationships to yeast SPT7 and ADA1. STAGA preferentially acetylates histone H3 within nucleosomes. #
SUZ12
(details) 		17101 SUZ12 polycomb repressive complex 2 subunit 23512 Q15022 SUZ12_HUMAN VEFS-Box PF09733 548-680 Suz12 1261758 Q80U70 SUZ12_MOUSE ZNF Zinc fingers, C2H2-type Histone modification write cofactor, Histone modification write cofactor, Polycomb group (PcG) protein, TF Histone methylation, Histone ubiquitination, TF repressor 15385962 PRC2 DNA DNA motif # 15385962 SUZ12 is a recently identified Polycomb group (PcG) protein, which together with EZH2 and EED forms different Polycomb repressive complexes (PRC2/3). #
TADA2A
(details) 		11531 transcriptional adaptor 2A 6871 O75478 TAD2A_HUMAN Myb_DNA-binding PF00249 74-118, domain PF22941 165-240, SWIRM PF04433 375-440 Tada2a 2144471 Q8CHV6 TAD2A_MOUSE # # Histone modification read, TF TF activator 19103755 PCAF, ATAC histone H3 # 19103755 The SANT domain of c-Myb has been shown to bind histone H3 tails and position them for acetylation. The SANT domains in ADA2a=TADA2A and ZZZ3/ATAC1 might enable the complex to associate with nucleosome tails in order to potentiate the catalytic activities of GCN5 and ATAC2, similar to what has been shown for the SANT domains in yeast Ada2 and Swi3. #
TADA2B
(details) 		30781 transcriptional adaptor 2B 93624 Q86TJ2 TAD2B_HUMAN Myb_DNA-binding PF00249 68-112, domain PF22941 164-237 Tada2b 3035274 # # # # Histone modification write cofactor Histone acetylation 17694077 TFTC-HAT histone # # 17694077 ADA2b =TADA2B is present in human STAGA/TFTC-type complexes. #
TADA3
(details) 		19422 transcriptional adaptor 3 10474 O75528 TADA3_HUMAN Ada3 PF10198 311-418 Tada3 1915724 Q8R0L9 TADA3_MOUSE # # Histone modification write cofactor Histone acetylation 11773077 PCAF, TFTC-HAT, ATAC, STAGA histone # # 11773077 Ada2 potentiates the Gcn5 catalytic activity and Ada3 =TADA3 facilitates nucleosomal acetylation and an expanded lysine specificity. #
TAF10
(details) 		11543 TAF10 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 30kDa 6881 Q12962 TAF10_HUMAN TFIID_30kDa PF03540 128-177 Taf10 1346320 Q8K0H5 TAF10_MOUSE # # Histone chaperone, Histone modification write Histone acetylation 15099517 PCAF, TFTC-HAT, SAGA, STAGA histone H3, H4 # 15099517 SET9 can monomethylate the TBP-associated factor TAF10 at a single lysine residue located at the loop 2 region within the putative histone-fold domain of the protein. #
TAF12
(details) 		11545 TAF12 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 20kDa 6883 Q16514 TAF12_HUMAN TFIID_20kDa PF03847 59-126 Taf12 1913714 Q8VE65 TAF12_MOUSE # # Histone chaperone, Histone modification write Histone acetylation 10594036 PCAF, STAGA histone # # 10594036 Heterodimerization requires the alpha2 and alpha3 helices of the hTAF(II)20 histone fold and is abolished by mutations in the hydrophobic face of the hTAF(II)20 alpha2 helix. Interaction with hTAF(II)20 requires a domain of hTAF(II)135 which shows sequence homology to H2A. #
TAF2
(details) 		11536 TAF2 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 150kDa 6873 Q6P1X5 TAF2_HUMAN Taf2 2443028 Q8C176 TAF2_MOUSE # # TF # # TFTC-HAT DNA DNA motif # # Added because it is a complex partner #
TAF4
(details) 		11537 TAF4 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 135kDa 6874 O00268 TAF4_HUMAN TAFH PF07531 592-680, TAF4 PF05236 833-1082 # # # # # # Histone chaperone # 10594036 TFTC-HAT, CHD8, MLL2/3, MLL4/WBP7 histone # # 10594036 The histone fold region of hTAFII135 is required for coactivator activity in mammalian cells. #
TAF5
(details) 		11539 TAF5 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 100kDa 6877 Q15542 TAF5_HUMAN TFIID_NTD2 PF04494 210-340, WD40 PF00400 466-498 535-571 577-612 618-655 660-697 703-739 Taf5 2442144 Q8C092 TAF5_MOUSE WDR WD repeat domain containing Histone modification write cofactor Histone acetylation 10373431 TFTC-HAT histone # # 10373431 TFTC, similar to other TBP-free TAFII complexes (yeast SAGA, hSTAGA, and hPCAF) contains the acetyltransferase hGCN5 and is able to acetylate histones in both a free and a nucleosomal context. A monoclonal antibody raised against hTAFII100 recognized hTAFII100=TAF5 not only in TFTC, but detected also a weak band in the PCAF complex. #
TAF5L
(details) 		17304 TAF5-like RNA polymerase II, p300/CBP-associated factor (PCAF)-associated factor, 65kDa 27097 O75529 TAF5L_HUMAN TFIID_NTD2 PF04494 66-196, WD40 PF00400 269-296 334-370 379-412 418-454 459-496 501-538 Taf5l 1919039 Q91WQ5 TAF5L_MOUSE WDR WD repeat domain containing Histone modification write cofactor Histone acetylation 10373431 PCAF, TFTC-HAT, STAGA histone # # 10373431 The PCAF complex contains hPAF65β=TAF5L, a WD40 repeat-containing factor having similarity to Htafii100(row=423) (5). Antibodies raised against hPAF65β revealed a band around 65 kDa in both the PCAF and the TFTC complexes. #
TAF6
(details) 		11540 TAF6 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 80kDa 6878 P49848 TAF6_HUMAN TAF PF02969 12-76, TAF6_C PF07571 214-399 Taf6 109129 Q62311 TAF6_MOUSE # # Histone chaperone # 9611234 TFTC-HAT, CHD8, MLL2/3, MLL4/WBP7 DNA # # 9611234 The N-CoR/Sin3/HDAc complexes have a key role in the regulation of cellular proliferation and differentiation. N-CoR interacts directly with each of the basal factors, TFIIB and TAFII70 (=TAF6). #
TAF6L
(details) 		17305 TAF6-like RNA polymerase II, p300/CBP-associated factor (PCAF)-associated factor, 65kDa 10629 Q9Y6J9 TAF6L_HUMAN TAF PF02969 10-73, TAF6_C PF07571 155-327 Taf6l 2444957 Q8R2K4 TAF6L_MOUSE # # Histone chaperone # 12601814 PCAF, TFTC-HAT, STAGA histone # # 12601814 Human PAF65-alpha shows a strong sequence homology to TAFII80 and also contains a putative HFD. Thus, PAF65-alpha may also interact with TAFII32 in the TFTC complex. #
TAF7
(details) 		11541 TAF7 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 55kDa 6879 Q15545 TAF7_HUMAN TAFII55_N PF04658 13-176 Taf7 1346348 Q9R1C0 TAF7_MOUSE # # Histone modification write cofactor, Histone modification write cofactor Histone methylation, Histone acetylation 22711989 CHD8, MLL2/3, MLL4/WBP7 histone # # 22711989 The largest transcription factor IID (TFIID) subunit, TBP-associated factor 1 (TAF1), possesses protein kinase and histone acetyltransferase (HAT) activities. #
TAF9
(details) 		11542 TAF9 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 32kDa 6880 Q16594 TAF9_HUMAN TFIID-31kDa PF02291 10-130 Taf9 1888697 Q8VI33 TAF9_MOUSE # # Histone chaperone # 9674425 PCAF, STAGA, CHD8, MLL2/3, MLL4/WBP7 DNA # # 9674425 Histone-like TAFs, including TAFII31 =TAF9, are found within the PCAF histone acetylase complex. #
TAF9B
(details) 		17306 TAF9B RNA polymerase II, TATA box binding protein (TBP)-associated factor, 31kDa 51616 Q9HBM6 TAF9B_HUMAN TFIID-31kDa PF02291 10-130 Taf9b 3039562 Q6NZA9 TAF9B_MOUSE # # Histone chaperone # 15899866 TFTC-HAT histone # # 15899866 TAF9b (formerly TAF9L) is a bona fide TAF that has unique and overlapping roles with TAF9. #
TFDP1
(details) 		11749 transcription factor Dp-1 7027 Q14186 TFDP1_HUMAN E2F_TDP PF02319 113-193, DP PF08781 200-338 Tfdp1 101934 Q08639 TFDP1_MOUSE # # Histone modification # 24217316, 22325352 RING2-L3MBTL2 histone # # 24217316, 22325352 Part of a RING2 complex. #
TFPT
(details) 		13630 TCF3 (E2A) fusion partner (in childhood Leukemia) 29844 P0C1Z6 TFPT_HUMAN Tfpt 1916964 Q3U1J1 TFPT_MOUSE INO80 INO80 complex subunits Chromatin remodeling cofactor, DNA modification DNA hydroxymethylation 16230350 Ino80 chromatin # # 16230350 Subunit Composition of the hINO80 Complex: These proteins included the “Pim-1 kinase-associated protein-associated protein 1” (PAPA-1, GI 13775202), Amida (also known as TCF3 =TFPT). #
TLE4
(details) 		11840 transducin-like enhancer of split 4 7091 Q04727 TLE4_HUMAN TLE_N PF03920 24-138, WD40 PF00400 480-514 534-561 580-605 610-647 695-728 742-769 Tle4 104633 Q62441 TLE4_MOUSE WDR WD repeat domain containing Histone modification erase cofactor, TF # 24190972 # histone H3ac, H4ac # 24190972 Tle4 is the transcriptional repressor responsible for the establishment of the epigenetic repressive marks at the Ifng locus that result in silencing of Ifng gene expression. Tle proteins have been shown to oligomerize, to associate with amino-terminal domains of histone-modifying proteins, and to form higher-order structures as parts of repressive complexes. #
TP53
(details) 		11998 tumor protein p53 7157 P04637 P53_HUMAN P53_TAD PF08563 13-33, TAD2 PF18521 23-55, P53 PF00870 101-288, P53_tetramer PF07710 323-357 Trp53 98834 P02340 P53_MOUSE # # Histone modification write cofactor, TF Histone acetylation, TF activator, TF repressor 23870121 # histone H3 # 23870121 SET1 complex (SET1C)-mediated H3K4 trimethylation is dependent upon p53- and p300-mediated H3 acetylation. Complementary cell-based assays demonstrate a DNA-damage-induced p53-SET1C interaction, a corresponding enrichment of SET1C and H3K4me3 on a p53 target gene (p21/WAF1), and a corresponding codependency of H3K4 trimethylation and transcription upon p300 and SET1C. #
TRRAP
(details) 		12347 transformation/transcription domain-associated protein 8295 Q9Y4A5 TRRAP_HUMAN Tra1_central PF20175 240-895, Tra1_ring PF20206 1003-2695, FAT PF02259 2851-3201, PI3_PI4_kinase PF00454 3531-3782 Trrap 2153272 Q80YV3 TRRAP_MOUSE # # Histone modification write cofactor Histone acetylation 14966270 SWR, PCAF, TFTC-HAT, NuA4, SAGA, NuA4-related complex, STAGA histone # # 14966270 The complex(es) contain(s) other subunits shared with NuA4, including TRRAP, p400/hDomino, Brd8. #
VDR
(details) 		12679 vitamin D (1,25- dihydroxyvitamin D3) receptor 7421 P11473 VDR_HUMAN zf-C4 PF00105 23-91, Hormone_recep PF00104 227-403 Vdr 103076 P48281 VDR_MOUSE NR Nuclear hormone receptors Chromatin remodeling cofactor, TF # 16252006 # histone H2BK12ac, H3K14ac, H4K16ac # 16252006 WINAC associates with chromatin through a physical interaction between the WSTF bromodomain and acetylated histones, which appears to be indispensable for VDR/promoter association for ligand-induced transrepression of 1α(OH)ase gene expression. #
WHSC1L1
(details) 		12767 Wolf-Hirschhorn syndrome candidate 1-like 1 54904 Q9BZ95 NSD3_HUMAN PWWP PF00855 269-348 962-1050, domain PF23011 700-746, domain PF22908 749-798, domain PF23004 799-851, AWS PF17907 1104-1142, SET PF00856 1155-1262, C5HCH PF17982 1366-1410 Whsc1l1 2142581 Q6P2L6 NSD3_MOUSE # # Chromatin remodeling cofactor, TF # 16682010 # histone H3K4, H3K27 # 16682010 WHISTLE =WHSC1L1 di-methylates H3K4 and di-, and tri-methylates H3K27 of histones. #
YEATS4
(details) 		24859 YEATS domain containing 4 8089 O95619 YETS4_HUMAN YEATS PF03366 42-121 Yeats4 1927224 Q9CR11 YETS4_MOUSE # # Histone modification write cofactor Histone acetylation 14966270 NuA4, NuA4-related complex, SRCAP histone # # 14966270 The essential GAS41 =YEATS4 protein is a member of the AF9/ENL-related (YEATS) family, and associated to transcription/chromatin-modifying complexes, including yeast NuA4, NuA3, Sas2, SWI/SNF, TFIID/mediator/TFIIF, and human SWI/SNF complexes. #
YY1
(details) 		12856 YY1 transcription factor 7528 P25490 TYY1_HUMAN zf-C2H2 PF00096 298-320 325-347 353-377 383-407 Yy1 99150 Q00899 TYY1_MOUSE INO80, ZNF INO80 complex subunits, Zinc fingers, C2H2-type Chromatin remodeling cofactor, TF TF repressor 11445535 Ino80 DNA DNA motif # 11445535 YY1 is complex comprising components of the evolutionarily conserved INO80 chromatin-remodeling complex. #
ZBTB33
(details) 		16682 zinc finger and BTB domain containing 33 10009 Q86T24 KAISO_HUMAN BTB PF00651 22-116 Zbtb33 1927290 Q8BN78 KAISO_MOUSE ZBTB, BTBD, ZNF BTB/POZ domain containing, Zinc fingers, C2H2-type Histone modification write cofactor, Histone modification erase cofactor, TF Histone acetylation, Histone methylation, TF repressor 14527417 # DNA CG, mCG, DNA motif # 14527417 Kaiso, a methyl CpG binding protein belonging to the BTB/POZ family of transcription factors, is a component of the human N-CoR complex. In vitro, the Kaiso/N-CoR complex binds specific CpG-rich sequences in a methylation-dependent manner. In vivo, Kaiso targets the N-CoR complex to the MTA2 gene promoter in a methylation-dependent manner. This repression also requires a functional N-CoR deacetylase complex, which brings about histone hypoacetylation and methylation of H3 lysine 9 to the MTA2 locus. #
ZBTB7A
(details) 		18078 Zinc finger and BTB domain-containing protein 7A (Factor binding IST protein 1) (FBI-1) (Factor that binds to inducer of short transcripts protein 1) (HIV-1 1st-binding protein 1) (Leukemia/lymphoma-related factor) (POZ and Krueppel erythroid myeloid ontogenic factor) (POK erythroid myeloid ontogenic factor) (Pokemon) (Pokemon 1) (TTF-I-interacting peptide 21) (TIP21) (Zinc finger protein 857A) 51341 O95365 ZBT7A_HUMAN BTB PF00651 24-129, zf-C2H2 PF00096 410-432 438-460 Zbtb7A 1335091 O88939 ZBT7A_MOUSE BTBD BTB domain containing RNA modification Alternative splicing 24514149 # RNA mRNA # 24514149 Regulates alternative splicing of BCL-X and apoptotic factors New
ZFP57
(details) 		18791 ZFP57 zinc finger protein 346171 Q9NU63 ZFP57_HUMAN KRAB PF01352 16-56, zf-C2H2 PF00096 91-113 119-141 147-169 175-197 300-322 328-350 Zfp57 99204 Q8C6P8 ZFP57_MOUSE # # TF TF repressor # # DNA mC, DNA motif # # Acts by controlling DNA methylation during the earliest multicellular stages of development at multiple imprinting control regions. (UniProt) #
ZGPAT
(details) 		15948 zinc finger, CCCH-type with G patch domain 84619 Q8N5A5 ZGPAT_HUMAN zf-CCCH_4 PF18044 177-199, G-patch PF01585 333-376 Zgpat 2449939 Q8VDM1 ZGPAT_MOUSE ZC3H, GPATCH Zinc fingers, CCCH-type domain containing, "G patch domain containing" TF TF repressor 22498752 # DNA DNA motif # # Recruits the chromatin multiprotein complex NuRD to target promoters. #
ZMYM2
(details) 		12989 zinc finger, MYM-type 2 7750 Q9UBW7 ZMYM2_HUMAN zf-FCS PF06467 328-364 371-412 422-457 465-504 534-571 637-674 681-716 725-762 766-803, DUF3504 PF12012 1190-1359 Zmym2 1923257 Q9CU65 ZMYM2_MOUSE ZMYM Zinc fingers, MYM type Histone modification erase cofactor, TF Histone acetylation 12493763 BHC, LSD-CoREST DNA DNA motif # 12493763 A family of HDAC1,2-associated complexes includes proteins with a putative role in DNA binding such as ZNF261/XFIM (=ZMYM3), ZNF198/FIM (=ZMYM2), and ZNF217. #
ZNF217
(details) 		13009 zinc finger protein 217 7764 O75362 ZN217_HUMAN zf-C2H2 PF00096 128-150 156-178 377-397 472-493 # # # # ZNF Zinc fingers, C2H2-type Histone modification erase cofactor, TF Histone acetylation, TF repressor 12493763 BHC, LSD-CoREST DNA # # 12493763 A family of HDAC1,2-associated complexes includes proteins with a putative role in DNA binding such as ZNF261/XFIM (=ZMYM3), ZNF198/FIM (=ZMYM2), and ZNF217. #
ZNF516
(details) 		28990 zinc finger protein 516 9658 Q92618 ZN516_HUMAN zf-C2H2 PF00096 34-56 62-84 248-270 276-298 1098-1120 Zfp516 2443957 Q7TSH3 ZN516_MOUSE ZNF Zinc fingers, C2H2-type Histone modification erase cofactor, TF Histone acetylation, TF repressor 23752268 LSD-CoREST histone, DNA # # 23752268 Part of the HDAC interactome, TF annotation from Uniprot. #