Gene info
| HGNC approved symbol | MBD2 |
| HGNC ID | HGNC:6917 |
| HGNC approved name | methyl-CpG binding domain protein 2 |
| Entrez gene ID | GeneID:8932 (SSTAR profile) |
| UniProt AC (human) | Q9UBB5 |
| UniProt ID (human) | MBD2_HUMAN |
| Pfam domains | MBD PF01429 (150-213) MBDa PF16564 (221-294) MBD_C PF14048 (296-385) |
| MGI symbol | Mbd2 |
| MGI ID | MGI:1333813 |
| UniProt AC (mouse) | Q9Z2E1 |
| UniProt ID (mouse) | MBD2_MOUSE |
| HGNC gene family tag | # |
| HGNC gene family description | # |
| Function | Histone modification write cofactor, Histone modification erase cofactor, TF |
| Modification | Histone methylation, Histone acetylation, TF repressor |
| PMID for information on function | PMID:16415179 |
| Protein complex | NuRD, MeCP1 |
| Target molecule | DNA |
| Target entity | mCG, DNA motif |
| HOCOMOCO TFBS model | |
| Product | # |
| PMID for information on target | PMID:16415179 |
| Comment | Wild-type subnuclear distribution of p66alpha and p66beta depends on the presence of MBD2. Both proteins interact with the tails of all octamer histones in vitro, and acetylation of histone tails interferes with p66 binding. |
| Status of entry | # |
Expression statistics
| Expression range: | 7.48 to 267.57 |
| Mean expression: | 55.48 ± 33.25 |
| Median expression: | 47.17 |