| HGNC approved symbol | SFPQ |
| HGNC ID | HGNC:10774 |
| HGNC approved name | splicing factor proline/glutamine-rich |
| Entrez gene ID | GeneID:6421 (SSTAR profile) |
| UniProt AC (human) | P23246 |
| UniProt ID (human) | SFPQ_HUMAN |
| Pfam domains | RRM_1 PF00076 (299-363, 374-432) NOPS PF08075 (444-496) |
| MGI symbol | Sfpq |
| MGI ID | MGI:1918764 |
| UniProt AC (mouse) | Q8VIJ6 |
| UniProt ID (mouse) | SFPQ_MOUSE |
| HGNC gene family tag | RBM |
| HGNC gene family description | RNA binding motif (RRM) containing |
| Function | Chromatin remodeling cofactor, RNA modification, TF |
| Modification | TF repressor |
| PMID for information on function | PMID:22783022, PMID:10858305, PMID:8449401 |
| Protein complex | # |
| Target molecule | DNA, RNA |
| Target entity | # |
| HOCOMOCO TFBS model | |
| Product | # |
| PMID for information on target | PMID:22783022, PMID:10858305, PMID:8449401 |
| Comment | Four components of the Sin3a transcriptional repressor complex: SAP130, SUDS3, SFPQ, and TGIF2. Since the RNA splicing factors do not have an endogenous DNA relaxation activity, topoisomerase I (Chromatin remodeller) gets stimulated by the interaction with the PSF= SFPQ/p54nrb heterodimer. PSF=SFPQ is an essential pre-mRNA splicing factor required early in spliceosome formation. |
| Status of entry | # |
| Expression range: | 73.46 to 1710.16 |
| Mean expression: | 402.14 ± 240.99 |
| Median expression: | 336.81 |