| HGNC approved symbol | MBD1 |
| HGNC ID | HGNC:6916 |
| HGNC approved name | methyl-CpG binding domain protein 1 |
| Entrez gene ID | GeneID:4152 (SSTAR profile) |
| UniProt AC (human) | Q9UIS9 |
| UniProt ID (human) | MBD1_HUMAN |
| Pfam domains | MBD PF01429 (2-70) zf-CXXC PF02008 (169-215, 219-262, 331-377) |
| MGI symbol | Mbd1 |
| MGI ID | MGI:1333811 |
| UniProt AC (mouse) | Q9Z2E2 |
| UniProt ID (mouse) | MBD1_MOUSE |
| HGNC gene family tag | # |
| HGNC gene family description | # |
| Function | Histone modification write cofactor, TF |
| Modification | Histone methylation, TF repressor |
| PMID for information on function | PMID:15327775 |
| Protein complex | # |
| Target molecule | DNA |
| Target entity | mCG, DNA motif |
| HOCOMOCO TFBS model | |
| Product | # |
| PMID for information on target | PMID:15327775 |
| Comment | MBD1 recruits SETDB1 to the large subunit of chromatin assembly factor CAF-1 to form an S phase-specific CAF-1/MBD1/SETDB1 complex that facilitates methylation of H3-K9 during replication-coupled chromatin assembly. In the absence of MBD1, H3-K9 methylation is lost at multiple genomic loci and results in activation of p53BP2 gene, normally repressed by MBD1 in HeLa cells. Data suggest a model in which H3-K9 methylation by SETDB1 is dependent on MBD1 and is heritably maintained through DNA replication to support the formation of stable heterochromatin at methylated DNA. |
| Status of entry | # |
| Expression range: | 0.0 to 108.53 |
| Mean expression: | 18.74 ± 9.42 |
| Median expression: | 16.82 |