HGNC approved symbol HGNC ID HGNC approved name Entrez gene ID UniProt AC (human)
UniProt ID (human)
Pfam domains MGI symbol MGI ID UniProt AC (mouse)
UniProt ID (mouse)
HGNC gene family tag HGNC gene family description Function Modification PMID for information on function Protein complex Target molecule Target entity Product PMID for information on target Comment Status of entry
C14orf169
(details) 		20968 # # Q9H6W3 NO66_HUMAN JmjC_2 PF08007 298-427, RIOX1_C_WH PF21233 511-637 - - Q9JJF3 NO66_MOUSE # # Histone modification erase Histone methylation 23160351 # histone H3K4me3, H3K4me1, H3K36me2 H3K4me2, H3K4, H3K36me1 23160351 H3K4me3 demethylase Rbp2 (Kdm5a). In addition to NO66=C14orf169, at least four other H3K36me3 demethylases are known. #
EHMT1
(details) 		24650 euchromatic histone-lysine N-methyltransferase 1 79813 Q9H9B1 EHMT1_HUMAN EHMT1-2_CRR PF21533 539-633, Ank_4 PF13637 772-836, Ank_2 PF12796 838-904 907-990, Pre-SET PF05033 1015-1118, SET PF00856 1137-1243 Ehmt1 1924933 Q5DW34 EHMT1_MOUSE KMT, ANKRD Chromatin-modifying enzymes / K-methyltransferases, Ankyrin repeat domain containing Histone modification write Histone methylation 18264113 # histone H3K9 H3K9me1, H3K9me2 18264113 G9a and G9a-like protein (GLP)=EHMT1 are euchromatin-associated methyltransferases that repress transcription by mono- and dimethylating histone H3 at Lys9 (H3K9). #
EHMT2
(details) 		14129 euchromatic histone-lysine N-methyltransferase 2 10919 Q96KQ7 EHMT2_HUMAN EHMT1-2_CRR PF21533 447-540, Ank_2 PF12796 655-746 750-816, Ank PF00023 850-882, Pre-SET PF05033 927-1030, SET PF00856 1049-1155 Ehmt2 2148922 Q9Z148 EHMT2_MOUSE KMT, ANKRD Chromatin-modifying enzymes / K-methyltransferases, Ankyrin repeat domain containing Histone modification write Histone methylation 18264113 # histone H3K9 H3K9me1, H3K9me2 18264113 G9a=EHMT2 and G9a-like protein (GLP) are euchromatin-associated methyltransferases that repress transcription by mono- and dimethylating histone H3 at Lys9 (H3K9). #
EZH1
(details) 		3526 enhancer of zeste 1 polycomb repressive complex 2 subunit 2145 Q92800 EZH1_HUMAN EZH2_WD-Binding PF11616 39-68, PRC2_HTH_1 PF18118 160-262, Ezh2_MCSS PF21358 267-322, preSET_CXC PF18264 560-591, SET PF00856 624-727 Ezh1 1097695 P70351 EZH1_MOUSE KMT Chromatin-modifying enzymes / K-methyltransferases Histone modification write, Polycomb group (PcG) protein Histone methylation 19026781 PRC2 histone H3K27 H3K27me1, H3K27me2, H3K27me3 19026781 Polycomb group proteins are critical to maintaining gene repression established during Drosophila development. Part of this group forms the PRC2 complex containing Ez that catalyzes di- and trimethylation of histone H3 lysine 27 (H3K37me2/3), marks repressive to transcription. The mammalian homologs Ezh1 and Ezh2 form similar PRC2 complexes but exhibit contrasting repressive roles. While PRC2-Ezh2 catalyzes H3K27me2/3 and its knockdown affects global H3K27me2/3 levels, PRC2-Ezh1 performs this function weakly. #
EZH2
(details) 		3527 enhancer of zeste 2 polycomb repressive complex 2 subunit 2146 Q15910 EZH2_HUMAN EZH2_WD-Binding PF11616 39-68, PRC2_HTH_1 PF18118 159-249, Ezh2_MCSS PF21358 259-309, preSET_CXC PF18264 559-590, SET PF00856 623-726 Ezh2 107940 Q61188 EZH2_MOUSE KMT Chromatin-modifying enzymes / K-methyltransferases Histone modification write, Polycomb group (PcG) protein Histone methylation 19026781 PRC2 histone H3K27 H3K27me1, H3K27me2, H3K27me3 19026781 Polycomb group proteins are critical to maintaining gene repression established during Drosophila development. Part of this group forms the PRC2 complex containing Ez that catalyzes di- and trimethylation of histone H3 lysine 27 (H3K37me2/3), marks repressive to transcription. The mammalian homologs Ezh1 and Ezh2 form similar PRC2 complexes, but exhibit contrasting repressive roles. While PRC2-Ezh2 catalyzes H3K27me2/3 and its knockdown affects global H3K27me2/3 levels, PRC2-Ezh1 performs this function weakly. #
HR
(details) 		5172 hair growth associated 55806 O43593 HAIR_HUMAN JmjC PF02373 1051-1139 Hr 96223 Q61645 HAIR_MOUSE # # Histone modification erase Histone methylation 24334705 # histone H3K9me1, H3K9me2 H3K9 24334705 HR can demethylate monomethylated or dimethylated histone H3 lysine 9 (H3K9me1 or me2). #
KDM1A
(details) 		29079 lysine (K)-specific demethylase 1A 23028 O60341 KDM1A_HUMAN SWIRM PF04433 183-264, Amino_oxidase PF01593 288-826 Kdm1a 1196256 Q6ZQ88 KDM1A_MOUSE KDM Chromatin-modifying enzymes / K-demethylases Histone modification erase Histone methylation 16223729 NuRD, BHC, SCL histone H3K4me1, H3K4me2, H3K9me H3K4, H3K9 16223729 Human histone demethylase LSD1=KDM1A is a flavin-dependent amine oxidase that catalyzes the specific removal of methyl groups from mono- and dimethylated Lys4 of histone H3. #
KDM1B
(details) 		21577 lysine (K)-specific demethylase 1B 221656 Q8NB78 KDM1B_HUMAN zf-CW PF07496 137-189, SWIRM PF04433 292-364, Amino_oxidase PF01593 392-819 Kdm1b 2145261 Q8CIG3 KDM1B_MOUSE KDM Chromatin-modifying enzymes / K-demethylases Histone modification erase Histone methylation 19727073 # histone H3K4me1, H3K4me2 H3K4 19727073 KDM1B is a histone H3K4 demethylase required to establish maternal genomic imprints. #
KDM3A
(details) 		20815 lysine (K)-specific demethylase 3A 55818 Q9Y4C1 KDM3A_HUMAN domain PF22989 8-82, domain PF22988 92-182, domain PF22987 184-249, JmjC PF02373 1158-1264 Kdm3a 98847 Q6PCM1 KDM3A_MOUSE KDM Chromatin-modifying enzymes / K-demethylases Histone modification erase Histone methylation 16603237 # histone H3K9me1, H3K9me2 H3K9 16603237 JHDM2A =KDM3A, a JmjC-containing H3K9 demethylase, facilitates transcription activation by androgen receptor. #
KDM3B
(details) 		1337 lysine (K)-specific demethylase 3B 51780 Q7LBC6 KDM3B_HUMAN domain PF22989 10-83, domain PF22988 91-188, domain PF22987 189-254, JmjC PF02373 1599-1704 Kdm3b 1923356 Q6ZPY7 KDM3B_MOUSE KDM Chromatin-modifying enzymes / K-demethylases Histone modification erase Histone methylation 16603237 # histone H3K9me1, H3K9me2 H3K9 16603237 A JmjC domain-containing protein (KDM3B=JmjC domain-containing histone demethylation protein 2B), JHDM2A, which specifically demethylates mono- and dimethyl-H3K9. #
KDM4B
(details) 		29136 lysine (K)-specific demethylase 4B 23030 O94953 KDM4B_HUMAN JmjN PF02375 16-50, JmjC PF02373 176-292, PHD_2 PF13831 754-789, zf-HC5HC2H_2 PF13832 796-907, Tudor_2 PF18104 922-956 978-1014 Kdm4b 2442355 Q91VY5 KDM4B_MOUSE KDM, TDRD Chromatin-modifying enzymes / K-demethylases, Tudor domain containing Histone modification erase Histone methylation 16603238 # histone H3K9me3 H3K9me1, H3K9me2 16603238 Human JMJD2(B, C, D) =KDM4(B, C, D) subfamily members function as trimethylation-specific demethylases, converting H3-K9Me3 to H3-K9Me2 and H3-K9Me1, respectively. #
KDM4C
(details) 		17071 lysine (K)-specific demethylase 4C 23081 Q9H3R0 KDM4C_HUMAN JmjN PF02375 17-51, JmjC PF02373 177-293, PHD_2 PF13831 712-747, zf-HC5HC2H_2 PF13832 754-864, Tudor_2 PF18104 881-916 939-974 Kdm4c 1924054 Q8VCD7 KDM4C_MOUSE KDM, TDRD Chromatin-modifying enzymes / K-demethylases, Tudor domain containing Histone modification erase Histone methylation 16603238 # histone H3K9me3, H3K36me3 H3K9me1, H3K9me2 16603238 Human JMJD2(B, C, D) =KDM4(B, C, D) subfamily members function as trimethylation-specific demethylases, converting H3-K9Me3 to H3-K9Me2 and H3-K9Me1, respectively. #
KDM4D
(details) 		25498 lysine (K)-specific demethylase 4D 55693 Q6B0I6 KDM4D_HUMAN JmjN PF02375 19-53, JmjC PF02373 179-295 Kdm4d 3606484 Q3U2K5 KDM4D_MOUSE KDM Chromatin-modifying enzymes / K-demethylases Histone modification erase Histone methylation 16603238 # histone H3K9me3 H3K9me1, H3K9me2 16603238 Human JMJD2(B, C, D) =KDM4(B, C, D) subfamily members function as trimethylation-specific demethylases, converting H3-K9Me3 to H3-K9Me2 and H3-K9Me1, respectively. #
KDM5C
(details) 		11114 lysine (K)-specific demethylase 5C 8242 P41229 KDM5C_HUMAN JmjN PF02375 15-48, ARID PF01388 80-165, PHD PF00628 327-371, JmjC PF02373 501-617, KDM5_C-hel PF21323 621-675, zf-C5HC2 PF02928 707-759, PLU-1 PF08429 771-1098 Kdm5c 99781 P41230 KDM5C_MOUSE KDM, PHF Chromatin-modifying enzymes / K-demethylases, Zinc fingers, PHD-type Histone modification erase Histone methylation 17320160 # histone H3K4me3 H3K4me2, H3K4me1 17320160 The X-linked mental retardation (XLMR) gene SMCX (JARID1C)=KDM5C, which encodes a JmjC-domain protein, reverses H3K4me3 to di- and mono- but not unmethylated products. #
KDM7A
(details) 		22224 lysine (K)-specific demethylase 7A 80853 Q6ZMT4 KDM7A_HUMAN PHD PF00628 40-85, JmjC PF02373 269-369, JHD PF17811 373-480 Kdm7a 2443388 Q3UWM4 KDM7A_MOUSE KDM, PHF Chromatin-modifying enzymes / K-demethylases, Zinc fingers, PHD-type Histone modification erase Histone methylation 20194436 # histone H3K9me2, H3K27me2, H4K20me1 H3K9, H3K27, H4K20 20194436 KDM7 (also known as JHDM1D) is a dual demethylase for H3K9 and H3K27 that functions as an eraser of silencing marks on chromatin during brain development. Specifically binds trimethylated 'Lys-4' of histone H3 (H3K4me3), affecting histone demethylase specificity: in presence of H3K4me3, it has no demethylase activity toward H3K9me2, while it has high activity toward H3K27me2. Demethylates H3K9me2 in absence of H3K4me3. Has activity toward H4K20Me1 only when nucleosome is used as a substrate and when not histone octamer is used as substrate. #
KMT2A
(details) 		7132 lysine (K)-specific methyltransferase 2A 4297 Q03164 KMT2A_HUMAN zf-CXXC PF02008 1149-1194, PHD PF00628 1481-1530 1569-1624, zf-HC5HC2H PF13771 1897-1978, FYRN PF05964 2016-2077, FYRC PF05965 3666-3747, SET PF00856 3840-3945 Kmt2a 96995 P55200 KMT2A_MOUSE KMT, PHF Chromatin-modifying enzymes / K-methyltransferases, Zinc fingers, PHD-type Histone modification write Histone methylation 19187761 MLL-HCF, CHD8, COMPASS-like MLL1,2 histone H3K4 H3K4me 19187761 MLL1 SET domain can incorporate methyl groups into unmodified or H3K4me1 substrates, signifying both mono- and dimethylation activity. #
KMT2E
(details) 		18541 lysine (K)-specific methyltransferase 2E 55904 Q8IZD2 KMT2E_HUMAN PHD_5 PF20826 118-164, SET PF00856 343-447 Kmt2e 1924825 Q3UG20 KMT2E_MOUSE KMT, PHF Chromatin-modifying enzymes / K-methyltransferases, Zinc fingers, PHD-type Histone modification write Histone methylation 19377461 # histone H3K4 H3K4me1, H3K4me2 19377461 Nuclear GlcNAcylation of the histone lysine methyltransferase (HKMT), MLL5, by O-GlcNAc transferase facilitates retinoic-acid-induced granulopoiesis in human HL60 promyelocytes through methylation of H3K4. #
MBTD1
(details) 		19866 mbt domain containing 1 54799 Q05BQ5 MBTD1_HUMAN zf-FCS_1 PF21319 52-82, MBT PF02820 189-248 289-352 388-459 496-560 Mbtd1 2143977 Q6P5G3 MBTD1_MOUSE # # Polycomb group (PcG) protein # 19841675 # histone H4K20me1, H4K20me2 # 19841675 MBTD1, Malignant Brain Tumor domain-containing protein 1, is a PcG protein. #
MSL3
(details) 		7370 male-specific lethal 3 homolog (Drosophila) 10943 Q8N5Y2 MS3L1_HUMAN domain PF22732 11-87, MRG PF05712 161-505 Msl3 1341851 Q9WVG9 MS3L1_MOUSE # # Histone modification read # 20943666 # histone H4K20me1 # 20943666 MSL3 plays an important role in targeting the male specific lethal complex to chromatin in both humans and flies by binding to H4K20Me. #
PHF8
(details) 		20672 PHD finger protein 8 23133 Q9UPP1 PHF8_HUMAN PHD PF00628 44-89, JmjC PF02373 270-370, JHD PF17811 374-481 Phf8 2444341 Q80TJ7 PHF8_MOUSE KDM, PHF Chromatin-modifying enzymes / K-demethylases, Zinc fingers, PHD-type Histone modification erase Histone methylation 21423274 # histone H3K9me1, H3K9me2, H3K27me2, H4K20me1, H3K36me2, H3K36me3, H3K4me3 H3K9, H3K27, H4K20, H3K36, H3K4 21423274 Table 1 in the reference. Via its PWWP domain it specifically binds trimethylated 'Lys-36' of histone H3 (H3K36me3): early recruitment to chromatin to be replicated allowing a quick identification of mismatch repair to initiate the DNA mismatch repair rea #
PRDM6
(details) 		9350 PR domain containing 6 93166 Q9NQX0 PRDM6_HUMAN PRDM2_PR PF21549 255-374, zf-C2H2 PF00096 501-523 529-551 557-577 Prdm6 2684938 Q3UZD5 PRDM6_MOUSE ZNF Zinc fingers, C2H2-type Histone modification write Histone methylation 17898714, 16537907 # histone H3R2, H4K20 H3R2me1, H3R2me2, H4K20me1 17898714, 18057026 The arginine methyltransferase PRMT6 catalyses H3R2 di-methylation in vitro and controls global levels of H3R2me2a in vivo. H3R2 methylation by PRMT6 was prevented by the presence of H3K4me3 on the H3 tail. PRISM =PRDM6 acts as a transcriptional repressor by interacting with class I histone deacetylases and the G9a histone methyltransferase, thereby identifying PRISM as a novel SMC-restricted epigenetic regulator. #
PRMT1
(details) 		5187 protein arginine methyltransferase 1 3276 Q99873 ANM1_HUMAN Methyltransf_25 PF13649 92-189, domain PF22528 194-358 Prmt1 107846 Q9JIF0 ANM1_MOUSE PRMT Protein arginine methyltransferases Histone modification write Histone methylation 11387442 # histone H4R3 H4R3me1, H4R3me2a 11387442 PRMT1 specifically methylates arginine 3 (Arg 3) of H4 in vitro and in vivo. Methylation of Arg 3 by PRMT1 facilitates subsequent acetylation of H4 tails by p300. #
RBBP5
(details) 		9888 retinoblastoma binding protein 5 5929 Q15291 RBBP5_HUMAN WD40 PF00400 29-52 62-94 Rbbp5 1918367 Q8BX09 RBBP5_MOUSE WDR WD repeat domain containing Histone modification write cofactor Histone methylation 19556245 COMPASS, Menin-associated_HMT, MLL-HCF, CHD8, MLL2/3, COMPASS-like MLL1,2, MLL4/WBP7, COMPASS-like MLL3,4 histone H3K4 H3K4me1, H3K4me2, H3K4me3 19556245 A five-component 200-kDa MLL1 core complex containing human MLL1, WDR5, RbBP5, Ash2L, and DPY-30. #
SETD7
(details) 		30412 SET domain containing (lysine methyltransferase) 7 80854 Q8WTS6 SETD7_HUMAN MORN PF02493 19-34 36-58 60-81, domain PF22648 110-184, SET PF00856 227-336 Setd7 1920501 Q8VHL1 SETD7_MOUSE KMT Chromatin-modifying enzymes / K-methyltransferases Histone modification write Histone methylation 11779497 # histone H3K4 H3K4me1 11779497 SET7 methylates H3-K4 in vitro and in vivo. In addition, methylation of H3-K4 and H3-K9 inhibit each other. Furthermore, H3-K4 and H3-K9 methylation by SET7 and SUV39H1, respectively, have differential effects on subsequent histone acetylation by p300. May explain differential effects of H3-K4 and H3-K9 methylation on transcription. #
SETD8
(details) 		29489 SET domain containing (lysine methyltransferase) 8 387893 Q9NQR1 SETD8_HUMAN SET PF00856 268-378 Setd8 1915206 Q2YDW7 SETD8_MOUSE KMT Chromatin-modifying enzymes / K-methyltransferases Histone modification write Histone methylation 12086618 # histone H4K20 H4K20me1 12086618 The encoding gene PR/SET07 =SETD8 of a human histone H4 lysine 20 methyltransferase. #
SIRT2
(details) 		10886 sirtuin 2 22933 Q8IXJ6 SIR2_HUMAN SIR2 PF02146 84-268 Sirt2 1927664 Q8VDQ8 SIR2_MOUSE # # Histone modification erase, Histone modification write cofactor Histone acetylation, Histone methylation 11427894 # histone H3K18ac, H3K56ac, H4K16ac, H4K20me1 H3K18, H3K56, H4K16, H4K20me2, H4K20me3 11427894 Sir2 =SIRT2 is an NAD-dependent histone deacetylase that mediates transcriptional silencing at mating-type loci, telomeres and ribosomal gene clusters. #
SUV39H1
(details) 		11479 suppressor of variegation 3-9 homolog 1 (Drosophila) 6839 O43463 SUV91_HUMAN Chromo PF00385 43-91, Pre-SET PF05033 141-235, SET PF00856 255-366 Suv39h1 1099440 O54864 SUV91_MOUSE KMT Chromatin-modifying enzymes / K-methyltransferases Histone modification write, Histone modification write Histone methylation, Histone phosphorylation 10949293 eNoSc histone H3S10, H3K9me1, H4 H3K9me3 10949293 In vivo, deregulated SUV39H1 or disrupted Suv39h activity modulate H3 serine 10 phosphorylation in native chromatin and induce aberrant mitotic divisions. #
SUV39H2
(details) 		17287 suppressor of variegation 3-9 homolog 2 (Drosophila) 79723 Q9H5I1 SUV92_HUMAN Chromo PF00385 47-95, Pre-SET PF05033 149-242, SET PF00856 262-373 Suv39h2 1890396 Q9EQQ0 SUV92_MOUSE KMT Chromatin-modifying enzymes / K-methyltransferases Histone modification write Histone methylation 15107829 # histone H3K9me1 H3K9me3 15107829 Suv39h proteins are histone methyltransferases that methylate histone H3 on lysine 9, resulting in transcriptional repression or silencing of target genes. #
WDR5
(details) 		12757 WD repeat domain 5 11091 P61964 WDR5_HUMAN WD40 PF00400 38-72 78-115 119-157 161-199 203-242 246-287 292-331 Wdr5 2155884 P61965 WDR5_MOUSE WDR WD repeat domain containing Histone modification read # 16946699 ATAC, NSL, RING2-L3MBTL2, COMPASS, Menin-associated_HMT, MLL-HCF, CHD8, MLL2/3, COMPASS-like MLL1,2, MLL4/WBP7, COMPASS-like MLL3,4 histone H3K4, H3K4me1, H3K4me2, H3K4me3 # 16946699 The WD40 domain of WDR5 represents a new class of histone methyl-lysine recognition domains that is important for recruiting H3K4 methyltransferases to K4-dimethylated histone H3 tail as well as for global and gene-specific K4 trimethylation. Here is given the crystal structures of full-length WDR5, WDR5Delta23 and its complexes with unmodified, mono-, di- and trimethylated histone H3K4 peptides. #