| HGNC approved symbol | EZH2 |
| HGNC ID | HGNC:3527 |
| HGNC approved name | enhancer of zeste 2 polycomb repressive complex 2 subunit |
| Entrez gene ID | GeneID:2146 (SSTAR profile) |
| UniProt AC (human) | Q15910 |
| UniProt ID (human) | EZH2_HUMAN |
| Pfam domains | EZH2_WD-Binding PF11616 (39-68) PRC2_HTH_1 PF18118 (159-249) Ezh2_MCSS PF21358 (259-309) preSET_CXC PF18264 (559-590) SET PF00856 (623-726) |
| MGI symbol | Ezh2 |
| MGI ID | MGI:107940 |
| UniProt AC (mouse) | Q61188 |
| UniProt ID (mouse) | EZH2_MOUSE |
| HGNC gene family tag | KMT |
| HGNC gene family description | Chromatin-modifying enzymes / K-methyltransferases |
| Function | Histone modification write, Polycomb group (PcG) protein |
| Modification | Histone methylation |
| PMID for information on function | PMID:19026781 |
| Protein complex | PRC2 |
| Target molecule | histone |
| Target entity | H3K27 |
| Product | H3K27me1, H3K27me2, H3K27me3 |
| PMID for information on target | PMID:19026781 |
| Comment | Polycomb group proteins are critical to maintaining gene repression established during Drosophila development. Part of this group forms the PRC2 complex containing Ez that catalyzes di- and trimethylation of histone H3 lysine 27 (H3K37me2/3), marks repressive to transcription. The mammalian homologs Ezh1 and Ezh2 form similar PRC2 complexes, but exhibit contrasting repressive roles. While PRC2-Ezh2 catalyzes H3K27me2/3 and its knockdown affects global H3K27me2/3 levels, PRC2-Ezh1 performs this function weakly. |
| Status of entry | # |
| Expression range: | 0.0 to 86.87 |
| Mean expression: | 10.45 ± 12.03 |
| Median expression: | 6.12 |