HGNC approved symbol HGNC ID HGNC approved name Entrez gene ID UniProt AC (human)
UniProt ID (human)
Pfam domains MGI symbol MGI ID UniProt AC (mouse)
UniProt ID (mouse)
HGNC gene family tag HGNC gene family description Function Modification PMID for information on function Protein complex Target molecule Target entity Product PMID for information on target Comment Status of entry
ANP32A
(details) 		13233 acidic (leucine-rich) nuclear phosphoprotein 32 family, member A 8125 P39687 AN32A_HUMAN LRR_9 PF14580 52-146 Anp32a 108447 O35381 AN32A_MOUSE ANP32 ANP32 acidic nuclear phosphoproteins Chromatin remodeling cofactor # 11163245 # chromatin # # 11163245 pp32 = ANP32A is a member of a family of leucine-rich acidic nuclear proteins ( 7 and 19). Results suggest potential roles of INHAT subunits in chromatin remodeling and transcriptional regulation; INHAT complex including pp32 inhibits the HAT activity of p300/CBP and PCAF by binding to their substrate, histones. #
BMI1
(details) 		1066 BMI1 proto-oncogene, polycomb ring finger 648 P35226 BMI1_HUMAN zf-C3HC4_2 PF13923 18-56, RAWUL PF16207 162-226 Bmi1 88174 P25916 BMI1_MOUSE RNF, PCGF RING-type (C3HC4) zinc fingers, Polycomb group ring fingers Polycomb group (PcG) protein # 15386022 PRC1 # # # 15386022 The complex, termed hPRC1L (human Polycomb repressive complex 1-like), is composed of several Polycomb-group proteins including Ring1, Ring2, Bmi1 and HPH2. #
BRD2
(details) 		1103 bromodomain containing 2 6046 P25440 BRD2_HUMAN Bromodomain PF00439 85-167 354-440, BET PF17035 640-704 Brd2 99495 Q7JJ13 BRD2_MOUSE # # Histone modification read # 18406326, 20495584 # histone H3K9me2, H3K14me2, H4K5ac, H4K12ac, H3K27ac # 18406326, 20495584 Brd2- and Brd3-associated chromatin is significantly enriched in H4K5, H4K12, and H3K14 acetylation and contains relatively little dimethylated H3K9. Both Brd2 and Brd3 allowed RNA polymerase II to transcribe through nucleosomes in a defined transcription system. Such activity depended on specific histone H4 modifications known to be recognized by the Brd proteins.. BRD2 is involved in recognizing acetylated lysines, including H3K27ac, and its involvement in transcriptional regulation. #
CDK9
(details) 		1780 cyclin-dependent kinase 9 1025 P50750 CDK9_HUMAN Pkinase PF00069 19-315 Cdk9 1328368 Q99J95 CDK9_MOUSE CDK Cyclin-dependent kinases Histone modification cofactor # 19844166 # histone # # # CDK9 functions to guide a complex network of chromatin modifications including histone H2B monoubiquitination (H2Bub1), H3 lysine 4 trimethylation (H3K4me3) and H3K36me3. UniProt: Protein kinase involved in the regulation of transcription. Part of the complex P-TEFb involved in cotranscriptional histone modification. #
CDYL2
(details) 		23030 chromodomain protein, Y-like 2 124359 Q8N8U2 CDYL2_HUMAN Chromo PF00385 7-57, ECH_1 PF00378 271-500 Cdyl2 1923046 Q9D5D8 CDYL2_MOUSE # # Histone modification read # 23455924 # histone H3K9me3 # 21774827 Many mouse chromodomain proteins are reported to bind H3K9me3 in vitro, including CDYL, CDYL2, CBX2, CBX4, CBX7 and M-phase phosphoprotein 8 (MPP8). #
EXOSC1
(details) 		17286 exosome component 1 51013 Q9Y3B2 EXOS1_HUMAN ECR1_N PF14382 8-43, EXOSC1 PF10447 95-135 Exosc1 1913833 Q9DAA6 EXOS1_MOUSE # # Scaffold protein, RNA modification RNA degradation 17174896 RNA exosome RNA # # 17174896 RNA abundance is regulated by balancing transcription and RNA degradation, processes that control the temporal and spatial distribution of cellular RNA. After decapping, 5′ to 3′ RNA degradation is accomplished by Xrn1, a 5′ to 3′ exoribonuclease. In the 3′ to 5′ pathway, RNA degradation is catalyzed by a multisubunit 3′ to 5′ exoribonuclease complex termed the RNA exosome. Three additional exosome subunits, Csl4=EXOSC1, Rrp4=EXOSC2, and Rrp40=EXOSC3, include S1 or KH domains, which are postulated to bind RNA. #
EXOSC2
(details) 		17097 exosome component 2 23404 Q13868 EXOS2_HUMAN ECR1_N PF14382 26-64, RRP4_S1 PF21266 75-146, KH_6 PF15985 169-210 Exosc2 2385133 Q8VBV3 EXOS2_MOUSE # # Scaffold protein, RNA modification RNA degradation 17174896 RNA exosome RNA # # 17174896 RNA abundance is regulated by balancing transcription and RNA degradation, processes that control the temporal and spatial distribution of cellular RNA. After decapping, 5′ to 3′ RNA degradation is accomplished by Xrn1, a 5′ to 3′ exoribonuclease. In the 3′ to 5′ pathway, RNA degradation is catalyzed by a multisubunit 3′ to 5′ exoribonuclease complex termed the RNA exosome. Three additional exosome subunits, Csl4=EXOSC1, Rrp4=EXOSC2, and Rrp40=EXOSC3, include S1 or KH domains, which are postulated to bind RNA. #
EXOSC3
(details) 		17944 exosome component 3 51010 Q9NQT5 EXOS3_HUMAN RRP40_N_mamm PF21261 26-106, RRP40_S1 PF21262 108-191, KH_6 PF15985 197-244 Exosc3 1913612 Q7TQK4 EXOS3_MOUSE # # Scaffold protein, RNA modification RNA degradation 17174896 RNA exosome RNA # # 17174896 RNA abundance is regulated by balancing transcription and RNA degradation, processes that control the temporal and spatial distribution of cellular RNA. After decapping, 5′ to 3′ RNA degradation is accomplished by Xrn1, a 5′ to 3′ exoribonuclease. In the 3′ to 5′ pathway, RNA degradation is catalyzed by a multisubunit 3′ to 5′ exoribonuclease complex termed the RNA exosome. Three additional exosome subunits, Csl4=EXOSC1, Rrp4=EXOSC2, and Rrp40=EXOSC3, include S1 or KH domains, which are postulated to bind RNA. #
EXOSC4
(details) 		18189 exosome component 4 54512 Q9NPD3 EXOS4_HUMAN RNase_PH PF01138 21-152, RNase_PH_C PF03725 155-219 Exosc4 1923576 Q921I9 EXOS4_MOUSE # # Scaffold protein, RNA modification RNA degradation 17174896 RNA exosome RNA # # 17174896 RNA abundance is regulated by balancing transcription and RNA degradation, processes that control the temporal and spatial distribution of cellular RNA. After decapping, 5′ to 3′ RNA degradation is accomplished by Xrn1, a 5′ to 3′ exoribonuclease. In the 3′ to 5′ pathway, RNA degradation is catalyzed by a multisubunit 3′ to 5′ exoribonuclease complex termed the RNA exosome. Three additional exosome subunits, Csl4=EXOSC1, Rrp4=EXOSC2, and Rrp40=EXOSC3, include S1 or KH domains, which are postulated to bind RNA. #
EXOSC5
(details) 		24662 exosome component 5 56915 Q9NQT4 EXOS5_HUMAN RNase_PH PF01138 28-147, RNase_PH_C PF03725 151-215 Exosc5 107889 Q9CRA8 EXOS5_MOUSE # # Scaffold protein, RNA modification RNA degradation 17174896 RNA exosome RNA # # 17174896 RNA abundance is regulated by balancing transcription and RNA degradation, processes that control the temporal and spatial distribution of cellular RNA. After decapping, 5′ to 3′ RNA degradation is accomplished by Xrn1, a 5′ to 3′ exoribonuclease. In the 3′ to 5′ pathway, RNA degradation is catalyzed by a multisubunit 3′ to 5′ exoribonuclease complex termed the RNA exosome. Three additional exosome subunits, Csl4=EXOSC1, Rrp4=EXOSC2, and Rrp40=EXOSC3, include S1 or KH domains, which are postulated to bind RNA. #
EXOSC6
(details) 		19055 exosome component 6 118460 Q5RKV6 EXOS6_HUMAN RNase_PH PF01138 37-175 Exosc6 1919794 Q8BTW3 EXOS6_MOUSE # # Scaffold protein, RNA modification RNA degradation 17174896 RNA exosome RNA # # 17174896 RNA abundance is regulated by balancing transcription and RNA degradation, processes that control the temporal and spatial distribution of cellular RNA. After decapping, 5′ to 3′ RNA degradation is accomplished by Xrn1, a 5′ to 3′ exoribonuclease. In the 3′ to 5′ pathway, RNA degradation is catalyzed by a multisubunit 3′ to 5′ exoribonuclease complex termed the RNA exosome. Three additional exosome subunits, Csl4=EXOSC1, Rrp4=EXOSC2, and Rrp40=EXOSC3, include S1 or KH domains, which are postulated to bind RNA. #
EXOSC7
(details) 		28112 exosome component 7 23016 Q15024 EXOS7_HUMAN RNase_PH PF01138 32-166, RNase_PH_C PF03725 196-261 Exosc7 1913696 Q9D0M0 EXOS7_MOUSE # # Scaffold protein, RNA modification RNA degradation 17174896 RNA exosome RNA # # 17174896 RNA abundance is regulated by balancing transcription and RNA degradation, processes that control the temporal and spatial distribution of cellular RNA. After decapping, 5′ to 3′ RNA degradation is accomplished by Xrn1, a 5′ to 3′ exoribonuclease. In the 3′ to 5′ pathway, RNA degradation is catalyzed by a multisubunit 3′ to 5′ exoribonuclease complex termed the RNA exosome. Three additional exosome subunits, Csl4=EXOSC1, Rrp4=EXOSC2, and Rrp40=EXOSC3, include S1 or KH domains, which are postulated to bind RNA. #
EXOSC8
(details) 		17035 exosome component 8 11340 Q96B26 EXOS8_HUMAN RNase_PH PF01138 31-166, RNase_PH_C PF03725 192-257 Exosc8 1916889 Q9D753 EXOS8_MOUSE # # Scaffold protein, RNA modification RNA degradation 17174896 RNA exosome RNA # # 17174896 RNA abundance is regulated by balancing transcription and RNA degradation, processes that control the temporal and spatial distribution of cellular RNA. After decapping, 5′ to 3′ RNA degradation is accomplished by Xrn1, a 5′ to 3′ exoribonuclease. In the 3′ to 5′ pathway, RNA degradation is catalyzed by a multisubunit 3′ to 5′ exoribonuclease complex termed the RNA exosome. Three additional exosome subunits, Csl4=EXOSC1, Rrp4=EXOSC2, and Rrp40=EXOSC3, include S1 or KH domains, which are postulated to bind RNA. #
EXOSC9
(details) 		9137 exosome component 9 5393 Q06265 EXOS9_HUMAN RNase_PH PF01138 32-163, RNase_PH_C PF03725 189-254 Exosc9 1355319 Q9JHI7 EXOS9_MOUSE # # Scaffold protein, RNA modification RNA degradation 17174896 RNA exosome RNA # # 17174896 RNA abundance is regulated by balancing transcription and RNA degradation, processes that control the temporal and spatial distribution of cellular RNA. After decapping, 5′ to 3′ RNA degradation is accomplished by Xrn1, a 5′ to 3′ exoribonuclease. In the 3′ to 5′ pathway, RNA degradation is catalyzed by a multisubunit 3′ to 5′ exoribonuclease complex termed the RNA exosome. Three additional exosome subunits, Csl4=EXOSC1, Rrp4=EXOSC2, and Rrp40=EXOSC3, include S1 or KH domains, which are postulated to bind RNA. #
GLYR1
(details) 		24434 glyoxylate reductase 1 homolog (Arabidopsis) 84656 Q49A26 GLYR1_HUMAN PWWP PF00855 8-89, NAD_binding_2 PF03446 269-425, NAD_binding_11 PF14833 431-551 Glyr1 1921272 Q922P9 GLYR1_MOUSE # # Histone modification read # 20850016 # histone H3K4me3 # 20850016 N-PAC=GLYR1, MSH-6, and NSD1 as well as NSD2 were identified as H3K36me3 interactors (Figure 1C; Table S2). Interestingly, these four proteins share a PWWP domain which is part of the Tudor domain “Royal Family” and includes the Tudor, chromo and MBT domains that can interact with methylated lysine residues. #
HNRPL
(details) 		5045 Heterogeneous nuclear ribonucleoprotein L (hnRNP L) 3191 P14866 HNRPL_HUMAN RRM_1 PF00076 106-155, RRM_8 PF11835 191-269, RRM_5 PF13893 361-480, domain PF22976 492-587 Hnrpl 104816 Q8R081 HNRPL_MOUSE RBM RNA binding motif containing RNA modification Alternative splicing 25623890 # RNA mRNA # 25623890 Regulates exon inclusion of CD44 New
IKBKAP
(details) 		5959 inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase complex-associated protein 8518 O95163 ELP1_HUMAN IKI3 PF04762 2-955 Ikbkap 1914544 Q7TT37 ELP1_MOUSE ELP Elongator acetyltransferase complex subunits Scaffold protein # 11818576, 11714725 Pol2 elongator # RNA # 11818576, 11714725 The human Elongator facilitates transcription by RNA polymerase II in a chromatin- and acetyl-CoA-dependent manner. Several human homologues of the yeast Elongator subunits have been identified as subunits of the human Elongator complex, including StIP1 (STAT-interacting protein 1) and IKAP (IKK complex-associated protein) =IKBKAP. #
KDM5D
(details) 		11115 lysine (K)-specific demethylase 5D 8284 Q9BY66 KDM5D_HUMAN JmjN PF02375 15-48, ARID PF01388 81-165, PHD PF00628 317-361, JmjC PF02373 491-607, KDM5_C-hel PF21323 611-665, zf-C5HC2 PF02928 697-749, PLU-1 PF08429 763-1085 Kdm5d 99780 Q62240 KDM5D_MOUSE KDM, PHF Chromatin-modifying enzymes / K-demethylases, Zinc fingers, PHD-type Histone modification erase Histone methylation 17320160 # histone H3K4me3, H3K4me2 H3K4 17320160 SMCX family members, including SMCY=KDM5D, RBP2, and PLU-1, demethylate H3K4me3. #
KMT2C
(details) 		13726 lysine (K)-specific methyltransferase 2C 58508 Q8NEZ4 KMT2C_HUMAN zf-HC5HC2H PF13771 248-331, PHD PF00628 343-389 390-436 466-519 958-1008, zf-HC5HC2H_2 PF13832 4401-4506, FYRN PF05964 4546-4604, FYRC PF05965 4608-4692, SET PF00856 4781-4887 Kmt2c 2444959 Q8BRH4 KMT2C_MOUSE KMT, PHF Chromatin-modifying enzymes / K-methyltransferases, Zinc fingers, PHD-type Histone modification write Histone methylation 20937768 MLL2/3, COMPASS-like MLL3,4 histone H3K4 H3K4me 20937768 In humans, multiple Set1-like HMT complexes with H3K4 HMT activities have been identified. Each of these complexes contains the SET domain-containing homologs of yeast Set1, including human Set1 (hSet1), MLL1 (mixed lineage leukemia 1, also known as MLL, HRX, ALL1, or KMT2A), MLL2 (mixed-lineage leukemia 2, also known as HRX2 or KMT2B), MLL3 (mixed-lineage leukemia 3, also known as HALR or KMT2C), and MLL4 (mixed-lineage leukemia 4, also known as ALR or KMT2D), which carry the enzymatic activity for the associated complexes. #
KMT2D
(details) 		7133 lysine (K)-specific methyltransferase 2D 8085 O14686 KMT2D_HUMAN zf-HC5HC2H PF13771 139-218, PHD PF00628 228-274 276-321 1379-1428 1429-1474, zf-HC5HC2H_2 PF13832 5031-5136, FYRN PF05964 5176-5233, FYRC PF05965 5236-5322, SET PF00856 5408-5513 Kmt2d 2682319 Q6PDK2 KMT2D_MOUSE KMT, PHF Chromatin-modifying enzymes / K-methyltransferases, Zinc fingers, PHD-type Histone modification write Histone methylation 20937768 COMPASS-like MLL1,2, MLL4/WBP7, COMPASS-like MLL3,4 histone H3K4 H3K4me 20937768 In humans, multiple Set1-like HMT complexes with H3K4 HMT activities have been identified. Each of these complexes contains the SET domain-containing homologs of yeast Set1, including human Set1 (hSet1), MLL1 (mixed lineage leukemia 1, also known as MLL, HRX, ALL1, or KMT2A), MLL2 (mixed-lineage leukemia 2, also known as HRX2 or KMT2B), MLL3 (mixed-lineage leukemia 3, also known as HALR or KMT2C), and MLL4 (mixed-lineage leukemia 4, also known as ALR or KMT2D), which carry the enzymatic activity for the associated complexes. #
MBNL1
(details) 		6923 Muscleblind-like protein 1 (Triplet-expansion RNA-binding protein) 4154 Q9NR56 MBNL1_HUMAN zf-CCCH_2 PF14608 19-39, domain PF22628 48-86 216-253, zf-CCCH PF00642 183-205 Mbnl1 1928482 Q9JKP5 MBNL1_MOUSE ZC3H Zinc fingers CCCH-type RNA modification Alternative splicing 16946708, 19470458, 15257297 # RNA mRNA # 16946708, 19470458, 15257297 Regulates the TNNT2 exon 5 skipping through competition with U2AF2. Inhibits cardiac troponin-T (TNNT2) pre-mRNA exon inclusion but induces insulin receptor (IR) pre-mRNA exon inclusion but induces insulin receptor (IR) pre-mRNA exon inclusion in muscle. Antagonistic regulator with CELF proteins. New
MBNL3
(details) 		20564 Muscleblind-like protein 3 (Cys3His CCG1-required protein) (Muscleblind-like X-linked protein) (Protein HCHCR) 55796 Q9NUK0 MBNL3_HUMAN zf-CCCH_2 PF14608 20-40, domain PF22628 49-87 211-248, zf-CCCH_4 PF18044 179-200 Mbnl3 2444912 Q8R003 MBNL3_MOUSE ZC3H Zinc fingers CCCH-type RNA modification Alternative splicing 15257297 # RNA mRNA # 15257297 Inhibits cardiac troponin-T (TNNT2) pre-mRNA exon inclusion but induces insulin receptor (IR) pre-mRNA exon inclusion in muscle. Antagonistic regulator with CELF proteins. New
NAA60
(details) 		25875 N(alpha)-acetyltransferase 60, NatF catalytic subunit 79903 Q9H7X0 NAA60_HUMAN Acetyltransf_1 PF00583 27-155 Naa60 1922013 Q9DBU2 NAA60_MOUSE NAA N(alpha)-acetyltransferase subunits Histone modification write Histone acetylation 21981917 # histone H4K20, H4K79, H4K91 H4K20ac, H4K79ac, H4K91ac 21981917 HAT4 =NAA60 is localized in the Golgi apparatus and displays a substrate preference for lysine residues of free histone H4, including H4K79 and H4K91, that reside in the globular domain of H4. #
NCL
(details) 		7667 nucleolin 4691 P19338 NUCL_HUMAN RRM_1 PF00076 309-377 395-459 488-554 574-641 Ncl 97286 P09405 NUCL_MOUSE RBM RNA binding motif (RRM) containing Histone chaperone # 16601700 # histone, DNA, RNA DNA motif, RNA motif # 16601700, 15371412 The nuclear protein nucleolin =NCL possesses a histone chaperone activity and this factor greatly enhances the activity of the chromatin remodeling machineries SWI/SNF and ACF. #
NCOA6
(details) 		15936 nuclear receptor coactivator 6 23054 Q14686 NCOA6_HUMAN NCOA6_TRADD-N PF13820 47-182 Ncoa6 1929915 Q9JL19 NCOA6_MOUSE # # Histone modification write cofactor Histone methylation 17500065 CHD8, MLL2/3, COMPASS-like MLL3,4 histone # # 17500065 Ectopically expressed PTIP is capable of interacting with DNA damage response proteins including 53BP1, while endogenous PTIP, and a novel protein PA1 are both components of a Set1-like histone methyltransferase (HMT) complex that also contains ASH2L, RBBP5, WDR5, hDPY-30, NCOA6, SET domain-containing HMTs MLL3 and MLL4, and substoichiometric amount of JmjC domain-containing putative histone demethylase UTX. #
PPARGC1A
(details) 		9237 peroxisome proliferator-activated receptor gamma, coactivator 1 alpha 10891 Q9UBK2 PRGC1_HUMAN RRM_1 PF00076 679-739 Ppargc1a 1342774 O70343 PRGC1_MOUSE RBM RNA binding motif (RRM) containing Histone modification cofactor # 10558993 # histone # # # PPARgamma coactivator-1 (PGC-1) promotes transcription through the assembly of a complex that includes the histone acetyltransferases steroid receptor coactivator-1 (SRC-1). Promotes transcription through the assembly of a complex that includes HAT p300. #
PPP4R2
(details) 		18296 protein phosphatase 4, regulatory subunit 2 151987 Q9NY27 PP4R2_HUMAN PPP4R2 PF09184 5-309 Ppp4r2 3027896 Q0VGB7 PP4R2_MOUSE PPP4R Serine/threonine phosphatases / Protein phosphatase 4, regulatory subunits Histone modification cofactor # 18614045 PPP4C-PPP4R2-PPP4R3A histone # # # Regulatory subunit of serine/threonine-protein phosphatase 4 (PP4) complex. PPARgamma coactivator-1 (PGC-1) promotes transcription through the assembly of a complex that includes the histone acetyltransferases steroid receptor coactivator-1 #
RBFOX1
(details) 		9910 RNA-binding motif protein, X chromosome (Glycoprotein p43) (Heterogeneous nuclear ribonucleoprotein G) (hnRNP G) [Cleaved into: RNA-binding motif protein, X chromosome, N-terminally processed] 27316 P38159 RBMX_HUMAN RRM_1 PF00076 10-80, RBM1CTR PF08081 169-221 Rbmx 1343044 Q9WV02 RBMX_MOUSE RBM RNA binding motif containing RNA modification Alternative splicing 12165565 # RNA mRNA # 12165565 Promotes exon 7 inclusion of SMN New
RBM24
(details) 		21539 RNA-binding protein 24 (RNA-binding motif protein 24) (RNA-binding region-containing protein 6) 221662 Q9BX46 RBM24_HUMAN RRM_1 PF00076 13-70 Rbm24 3610364 D3Z4I3 RBM24_MOUSE RBM RNA binding motif containing RNA modification Alternative splicing 29104163, 26990106 # RNA mRNA # 29104163, 26990106 Promotes alternative splicing events of several pluripotency and/or differentiation genes. Mediates preferentially muscle-specific exon inclusion in numerous mRNAs important for striated cardiac and skeletal muscle cell differentiation New
RFOX1
(details) 		18222 RNA binding protein fox-1 homolog 1 (Ataxin-2-binding protein 1) (Fox-1 homolog A) (Hexaribonucleotide-binding protein 1) 54715 Q9NWB1 RFOX1_HUMAN RRM_1 PF00076 120-186, Fox-1_C PF12414 254-342 Rbfox1 1926224 Q9JJ43 RFOX1_MOUSE RBM RNA binding motif containing RNA modification Alternative splicing 16537540 # RNA mRNA # 16537540 Activates inclusion of 4.1R exon 16 New
RING1
(details) 		10018 ring finger protein 1 6015 Q06587 RING1_HUMAN zf-C3HC4_2 PF13923 47-87, RAWUL PF16207 282-400 Ring1 1101770 O35730 RING1_MOUSE RNF RING-type (C3HC4) zinc fingers Histone modification write, Polycomb group (PcG) protein Histone ubiquitination 15386022 PRC1, BCOR, RING2-L3MBTL2, RING2-FBRS histone H2AK119 H2AK119ub 15386022 The complex hPRC1L (human Polycomb repressive complex 1-like) is composed of several Polycomb-group proteins including Ring1, Ring2, Bmi1 and HPH2. hPRC1L monoubiquitinates nucleosomal histone H2A at lysine 119. #
RUVBL2
(details) 		10475 RuvB-like AAA ATPase 2 10856 Q9Y230 RUVB2_HUMAN TIP49 PF06068 21-364, TIP49_C PF17856 370-435 Ruvbl2 1342299 Q9WTM5 RUVB2_MOUSE INO80, AATP INO80 complex subunits, ATPases / AAA-type Chromatin remodeling cofactor # 18026119 Ino80, SWR, NuA4, NuA4-related complex, CHD8, MLL2/3, MLL4/WBP7, SRCAP chromatin # # 18026119 The seven human INO80 complex components include TIP49A and TIP49B (previously identified as ‘RuvB-like’ proteins, and labeled RUVBL1 and RUVBL2). #
SETD1A
(details) 		29010 SET domain containing 1A 9739 O15047 SET1A_HUMAN RRM_1 PF00076 97-166, N-SET PF11764 1419-1559, SET PF00856 1580-1685 Setd1a 2446244 # # KMT, RBM Chromatin-modifying enzymes / K-methyltransferases, RNA binding motif (RRM) containing Histone modification write Histone methylation 17355966 COMPASS histone H3K4 H3K4me 17355966 The CFP1 complex contains human homologues of the COMPASS complex, including Set1A=SETD1A, Wdr5, Ash2, Rbbp5, and Wdr82 (previously denoted hSwd2). The human Set1A-CFP1 complex exhibits histone H3-Lys4 methyltransferase activity in vitro. #
SETD6
(details) 		26116 SET domain containing 6 79918 Q8TBK2 SETD6_HUMAN SET PF00856 75-286, Rubis-subs-bind PF09273 328-465 Setd6 1913333 Q9CWY3 SETD6_MOUSE # # Chromatin remodeling, Histone modification write Histone methylation 21131967 # histone # # 21131967 SETD6 monomethylation of nuclear RelA at K310 attenuates NF-κB signaling by docking GLP (via its ankyrin repeats) at target genes to generate a silent chromatin state, effectively rendering chromatin-bound RelA inert. As deregulation of NF-κB is linked to pathologic inflammatory processes and cancer8 and SETD6 inhibits NF-κB signaling in diverse cell types, including primary human cells, SETD6 may provide a new link by which protein lysine methylation and chromatin regulation influence tumor suppression and anti-inflammatory respons. #
SF3B1
(details) 		10768 splicing factor 3b, subunit 1, 155kDa 23451 O75533 SF3B1_HUMAN SF3b1 PF08920 327-453, domain PF22646 1086-1158 Sf3b1 1932339 Q99NB9 SF3B1_MOUSE # # RNA modification # 23568491 B-WICH RNA # # 23568491 Although the causative link between SF3B1 mutation and CLL pathogenesis remains unclear, several lines of evidence suggest SF3B1 mutation might be linked to genomic stability and epigenetic modification. #
SKP1
(details) 		10899 S-phase kinase-associated protein 1 6500 P63208 SKP1_HUMAN Skp1_POZ PF03931 3-68, Skp1 PF01466 113-160 Akp1a 103575 Q9WTX5 SKP1_MOUSE # # Histone modification write cofactor Histone ubiquitination 16943429 BCOR histone # # 16943429 The proteins in the BCOR complex include the PcG and PcG-associated proteins NSPC1, RING1, RNF2, and RYBP as well as components of an SCF ubiquitin ligase, SKP1, and FBXL10. BCOR recruits a unique combination of enzymatic activities to chromatin targets: a PcG E3 ubiquitin ligase for histone H2A, a demethylase for histone H3 K36, and an SCF E3 ubiquitin ligase. #
SPEN
(details) 		17575 spen family transcriptional repressor 23013 Q96T58 MINT_HUMAN RRM_1 PF00076 8-67 337-407 439-508 519-583, MINT_MID PF20809 2012-3467, MINT_RID PF20810 2366-2584 3009-3469, MINT_RAM7 PF20808 2654-2749, SPOC PF07744 3506-3662 Spen 1891706 Q62504 MINT_MOUSE RBM RNA binding motif (RRM) containing Histone modification erase cofactor, TF Histone acetylation, TF activator, TF repressor 11331609 # histone # # 11331609 SHARP =SPEN recruits histone deacetylase activity. SHARP is a potent transcriptional repressor whose repression domain (RD) interacts directly with SMRT and at least five members of the NuRD complex including HDAC1 and HDAC2. #
SRSF6
(details) 		10788 Serine/arginine-rich splicing factor 6 (Pre-mRNA-splicing factor SRP55) (Splicing factor, arginine/serine-rich 6) 6431 Q13247 SRSF6_HUMAN RRM_1 PF00076 4-64 112-177 Srsf6 1915246 Q3TWW8 SRSF6_MOUSE RBM RNA binding motif containing RNA modification Alternative splicing 22767602 # RNA mRNA # 22767602 Promotes Tau exon 10 inclusion New
SUPT7L
(details) 		30632 suppressor of Ty 7 (S. cerevisiae)-like 9913 O94864 ST65G_HUMAN Bromo_TP PF07524 151-228 Supt7l 1919445 Q9CZV5 ST65G_MOUSE # # Histone chaperone # 11564863 TFTC-HAT, STAGA histone # # 11564863 STAGA contains homologs of most yeast SAGA components, including two novel human proteins with histone-like folds and sequence relationships to yeast SPT7 and ADA1. STAGA preferentially acetylates histone H3 within nucleosomes. #
TAF9
(details) 		11542 TAF9 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 32kDa 6880 Q16594 TAF9_HUMAN TFIID-31kDa PF02291 10-130 Taf9 1888697 Q8VI33 TAF9_MOUSE # # Histone chaperone # 9674425 PCAF, STAGA, CHD8, MLL2/3, MLL4/WBP7 DNA # # 9674425 Histone-like TAFs, including TAFII31 =TAF9, are found within the PCAF histone acetylase complex. #
TET1
(details) 		29484 tet methylcytosine dioxygenase 1 80312 Q8NFU7 TET1_HUMAN zf-CXXC PF02008 585-625, Tet_JBP PF12851 1580-2051 Tet1 1098693 Q3URK3 TET1_MOUSE # # DNA modification DNA hydroxymethylation 23222540 # DNA mC hmC 23222540 Ten eleven translocation (TET) enzymes, including TET1, TET2 and TET3, convert 5-methylcytosine to 5-hydroxymethylcytosine and regulate gene transcription. #
TET2
(details) 		25941 tet methylcytosine dioxygenase 2 54790 Q6N021 TET2_HUMAN Tet_JBP PF12851 1290-1904 Tet2 2443298 Q4JK59 TET2_MOUSE # # DNA modification DNA hydroxymethylation 23222540 # DNA mC hmC 23222540 Ten eleven translocation (TET) enzymes, including TET1, TET2 and TET3, convert 5-methylcytosine to 5-hydroxymethylcytosine and regulate gene transcription. Downregulation of TET2 reduces the amount of histone 2B Ser 112 GlcNAc marks in vivo, which are associated with gene transcription regulation. #
TET3
(details) 		28313 tet methylcytosine dioxygenase 3 200424 O43151 TET3_HUMAN zf-CXXC PF02008 52-90, Tet_JBP PF12851 986-1697 Tet3 2446229 Q8BG87 TET3_MOUSE # # DNA modification DNA hydroxymethylation 23222540 # DNA mC hmC 23222540 Ten eleven translocation (TET) enzymes, including TET1, TET2 and TET3, convert 5-methylcytosine to 5-hydroxymethylcytosine and regulate gene transcription. There is a direct interaction of TET2 and TET3 with O-GlcNAc transferase (OGT). #
TFPT
(details) 		13630 TCF3 (E2A) fusion partner (in childhood Leukemia) 29844 P0C1Z6 TFPT_HUMAN Tfpt 1916964 Q3U1J1 TFPT_MOUSE INO80 INO80 complex subunits Chromatin remodeling cofactor, DNA modification DNA hydroxymethylation 16230350 Ino80 chromatin # # 16230350 Subunit Composition of the hINO80 Complex: These proteins included the “Pim-1 kinase-associated protein-associated protein 1” (PAPA-1, GI 13775202), Amida (also known as TCF3 =TFPT). #
TLE2
(details) 		11838 transducin-like enhancer of split 2 7089 Q04725 TLE2_HUMAN TLE_N PF03920 18-130, WD40 PF00400 450-484 504-531 550-575 580-617 665-698 712-739 Tle2 104635 Q9WVB2 TLE2_MOUSE WDR WD repeat domain containing Histone modification cofactor # 17041588 # histone H3 H3K4, H3K9, H3K27me 17041588 CUL4-DDB1 complexes interact with multiple WD40-repeat proteins (WDRs) including TLE1-3, WDR5, L2DTL (also known as CDT2) and the Polycomb-group protein EED (also known as ESC). WDR5 and EED are core components of histone methylation complexes that are essential for histone H3 methylation and epigenetic control at K4 or K9 and K27, respectively. #
TRA2B
(details) 		10781 Transformer-2 protein homolog beta (TRA-2 beta) (TRA2-beta) (hTRA2-beta) (Splicing factor, arginine/serine-rich 10) (Transformer-2 protein homolog B) 6434 P62995 TRA2B_HUMAN RRM_1 PF00076 122-190 Tra2B 106016 P62996 TRA2B_MOUSE RBM RNA binding motif containing RNA modification Alternative splicing 12165565 # RNA mRNA # 12165565 Promotes exon 7 inclusion of SMN New
TRRAP
(details) 		12347 transformation/transcription domain-associated protein 8295 Q9Y4A5 TRRAP_HUMAN Tra1_central PF20175 240-895, Tra1_ring PF20206 1003-2695, FAT PF02259 2851-3201, PI3_PI4_kinase PF00454 3531-3782 Trrap 2153272 Q80YV3 TRRAP_MOUSE # # Histone modification write cofactor Histone acetylation 14966270 SWR, PCAF, TFTC-HAT, NuA4, SAGA, NuA4-related complex, STAGA histone # # 14966270 The complex(es) contain(s) other subunits shared with NuA4, including TRRAP, p400/hDomino, Brd8. #
WSB2
(details) 		19222 WD repeat and SOCS box containing 2 55884 Q9NYS7 WSB2_HUMAN WD40 PF00400 145-182 188-225 231-267 289-320 338-360, SOCS_box PF07525 367-401 Wsb2 2144041 O54929 WSB2_MOUSE WDR WD repeat domain containing Histone modification write Histone ubiquitination 21070969 # histone # # # May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, including histones. (Annotated by similarity). #
YEATS4
(details) 		24859 YEATS domain containing 4 8089 O95619 YETS4_HUMAN YEATS PF03366 42-121 Yeats4 1927224 Q9CR11 YETS4_MOUSE # # Histone modification write cofactor Histone acetylation 14966270 NuA4, NuA4-related complex, SRCAP histone # # 14966270 The essential GAS41 =YEATS4 protein is a member of the AF9/ENL-related (YEATS) family, and associated to transcription/chromatin-modifying complexes, including yeast NuA4, NuA3, Sas2, SWI/SNF, TFIID/mediator/TFIIF, and human SWI/SNF complexes. #
ZMYM2
(details) 		12989 zinc finger, MYM-type 2 7750 Q9UBW7 ZMYM2_HUMAN zf-FCS PF06467 328-364 371-412 422-457 465-504 534-571 637-674 681-716 725-762 766-803, DUF3504 PF12012 1190-1359 Zmym2 1923257 Q9CU65 ZMYM2_MOUSE ZMYM Zinc fingers, MYM type Histone modification erase cofactor, TF Histone acetylation 12493763 BHC, LSD-CoREST DNA DNA motif # 12493763 A family of HDAC1,2-associated complexes includes proteins with a putative role in DNA binding such as ZNF261/XFIM (=ZMYM3), ZNF198/FIM (=ZMYM2), and ZNF217. #
ZMYM3
(details) 		13054 zinc finger, MYM-type 3 9203 Q14202 ZMYM3_HUMAN zf-FCS PF06467 353-389 406-444 449-490 497-535 546-580 591-624 632-664 676-714 718-754, DUF3504 PF12012 1184-1354 Zmym3 1927231 Q9JLM4 ZMYM3_MOUSE ZMYM Zinc fingers, MYM type Histone modification erase cofactor Histone acetylation 12493763 BHC DNA # # 12493763 A family of HDAC1,2-associated complexes includes proteins with a putative role in DNA binding such as ZNF261/XFIM (=ZMYM3), ZNF198/FIM (=ZMYM2), and ZNF217. #
ZNF217
(details) 		13009 zinc finger protein 217 7764 O75362 ZN217_HUMAN zf-C2H2 PF00096 128-150 156-178 377-397 472-493 # # # # ZNF Zinc fingers, C2H2-type Histone modification erase cofactor, TF Histone acetylation, TF repressor 12493763 BHC, LSD-CoREST DNA # # 12493763 A family of HDAC1,2-associated complexes includes proteins with a putative role in DNA binding such as ZNF261/XFIM (=ZMYM3), ZNF198/FIM (=ZMYM2), and ZNF217. #
ZNF711
(details) 		13128 zinc finger protein 711 7552 Q9Y462 ZN711_HUMAN Zfx_Zfy_act PF04704 62-356, zf-C2H2 PF00096 383-405 505-527 562-584 590-613 619-641 676-698 704-727 733-755 Zfp711 3045342 A2ANX9 ZN711_MOUSE ZNF Zinc fingers, C2H2-type Histone modification erase cofactor Histone acetylation 20346720 # histone # # 20346720 The PHD domain of PHF8 binds to H3K4me3 and colocalizes with H3K4me3 at transcription initiation sites. Furthermore, PHF8 interacts with another XMLR protein, ZNF711, which binds to a subset of PHF8 target genes, including the XLMR gene JARID1C. #
ZRANB3
(details) 		25249 zinc finger, RAN-binding domain containing 3 84083 Q5FWF4 ZRAB3_HUMAN SNF2-rel_dom PF00176 40-299, Helicase_C PF00271 329-435, zf-RanBP PF00641 623-648, HNH PF01844 1014-1049 Zranb3 1918362 Q6NZP1 ZRAB3_MOUSE ZRANB Zinc fingers, RAN-binding domain containing Chromatin remodeling, Histone modification read cofactor Histone methylation 22705370 # histone # # 22705370 All four proteins (HARP, HARP-like domain (HPL), SMARCA1, RAD54L) belong to the SNF2 =ZRANB3 family, whose members participate in a variety of processes including chromatin remodeling, transcription, DNA repair, and recombination. #