| HGNC approved symbol | SETD6 |
| HGNC ID | HGNC:26116 |
| HGNC approved name | SET domain containing 6 |
| Entrez gene ID | GeneID:79918 (SSTAR profile) |
| UniProt AC (human) | Q8TBK2 |
| UniProt ID (human) | SETD6_HUMAN |
| Pfam domains | SET PF00856 (75-286) Rubis-subs-bind PF09273 (328-465) |
| MGI symbol | Setd6 |
| MGI ID | MGI:1913333 |
| UniProt AC (mouse) | Q9CWY3 |
| UniProt ID (mouse) | SETD6_MOUSE |
| HGNC gene family tag | # |
| HGNC gene family description | # |
| Function | Chromatin remodeling, Histone modification write |
| Modification | Histone methylation |
| PMID for information on function | PMID:21131967 |
| Protein complex | # |
| Target molecule | histone |
| Target entity | # |
| Product | # |
| PMID for information on target | PMID:21131967 |
| Comment | SETD6 monomethylation of nuclear RelA at K310 attenuates NF-κB signaling by docking GLP (via its ankyrin repeats) at target genes to generate a silent chromatin state, effectively rendering chromatin-bound RelA inert. As deregulation of NF-κB is linked to pathologic inflammatory processes and cancer8 and SETD6 inhibits NF-κB signaling in diverse cell types, including primary human cells, SETD6 may provide a new link by which protein lysine methylation and chromatin regulation influence tumor suppression and anti-inflammatory respons. |
| Status of entry | # |
| Expression range: | 0.0 to 33.44 |
| Mean expression: | 6.69 ± 4.46 |
| Median expression: | 5.83 |