| HGNC approved symbol | KMT2C |
| HGNC ID | HGNC:13726 |
| HGNC approved name | lysine (K)-specific methyltransferase 2C |
| Entrez gene ID | GeneID:58508 (SSTAR profile) |
| UniProt AC (human) | Q8NEZ4 |
| UniProt ID (human) | KMT2C_HUMAN |
| Pfam domains | zf-HC5HC2H PF13771 (248-331) PHD PF00628 (343-389, 390-436, 466-519, 958-1008) zf-HC5HC2H_2 PF13832 (4401-4506) FYRN PF05964 (4546-4604) FYRC PF05965 (4608-4692) SET PF00856 (4781-4887) |
| MGI symbol | Kmt2c |
| MGI ID | MGI:2444959 |
| UniProt AC (mouse) | Q8BRH4 |
| UniProt ID (mouse) | KMT2C_MOUSE |
| HGNC gene family tag | KMT, PHF |
| HGNC gene family description | Chromatin-modifying enzymes / K-methyltransferases, Zinc fingers, PHD-type |
| Function | Histone modification write |
| Modification | Histone methylation |
| PMID for information on function | PMID:20937768 |
| Protein complex | MLL2/3, COMPASS-like MLL3,4 |
| Target molecule | histone |
| Target entity | H3K4 |
| Product | H3K4me |
| PMID for information on target | PMID:20937768 |
| Comment | In humans, multiple Set1-like HMT complexes with H3K4 HMT activities have been identified. Each of these complexes contains the SET domain-containing homologs of yeast Set1, including human Set1 (hSet1), MLL1 (mixed lineage leukemia 1, also known as MLL, HRX, ALL1, or KMT2A), MLL2 (mixed-lineage leukemia 2, also known as HRX2 or KMT2B), MLL3 (mixed-lineage leukemia 3, also known as HALR or KMT2C), and MLL4 (mixed-lineage leukemia 4, also known as ALR or KMT2D), which carry the enzymatic activity for the associated complexes. |
| Status of entry | # |
| Expression range: | 0.0 to 237.05 |
| Mean expression: | 20.99 ± 21.65 |
| Median expression: | 13.92 |