| HGNC approved symbol | EXOSC1 |
| HGNC ID | HGNC:17286 |
| HGNC approved name | exosome component 1 |
| Entrez gene ID | GeneID:51013 (SSTAR profile) |
| UniProt AC (human) | Q9Y3B2 |
| UniProt ID (human) | EXOS1_HUMAN |
| Pfam domains | ECR1_N PF14382 (8-43) EXOSC1 PF10447 (95-135) |
| MGI symbol | Exosc1 |
| MGI ID | MGI:1913833 |
| UniProt AC (mouse) | Q9DAA6 |
| UniProt ID (mouse) | EXOS1_MOUSE |
| HGNC gene family tag | # |
| HGNC gene family description | # |
| Function | Scaffold protein, RNA modification |
| Modification | RNA degradation |
| PMID for information on function | PMID:17174896 |
| Protein complex | RNA exosome |
| Target molecule | RNA |
| Target entity | # |
| Product | # |
| PMID for information on target | PMID:17174896 |
| Comment | RNA abundance is regulated by balancing transcription and RNA degradation, processes that control the temporal and spatial distribution of cellular RNA. After decapping, 5′ to 3′ RNA degradation is accomplished by Xrn1, a 5′ to 3′ exoribonuclease. In the 3′ to 5′ pathway, RNA degradation is catalyzed by a multisubunit 3′ to 5′ exoribonuclease complex termed the RNA exosome. Three additional exosome subunits, Csl4=EXOSC1, Rrp4=EXOSC2, and Rrp40=EXOSC3, include S1 or KH domains, which are postulated to bind RNA. |
| Status of entry | # |
| Expression range: | 5.98 to 152.55 |
| Mean expression: | 36.69 ± 14.78 |
| Median expression: | 35.92 |